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Protein Overview: nAcRalpha-96Aa-P...

General Information:
Name(s) found: FBpp0306936 [FlyBase]
nAcRalpha-96Aa-PA / FBpp0084003 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=3R:complement(20227461..20227667,20228937..20229232,20230404..20230615,20230691..20231151,20233040..20233220,20238230..20238339,20240569..20240613,20247417..20247608); ID=FBpp0306936; name=nAChRalpha1-PC; parent=FBgn0000036,FBtr0334916; dbxref=FlyBase:FBpp0306936,FlyBase_Annotation_IDs:CG5610-PC,REFSEQ:NP_001262917,GB_protein:AGB96297; MD5=c27b3162d150908887f07f4f39d55806; length=567; release=r5.56; species=Dmel; [FlyBase]
  • The gene nicotinic Acetylcholine Receptor alpha 96Aa is referred to in FlyBase by the symbol Dmel\nAcRÃ?&#142;Ã?±-96Aa (CG5610, FBgn0000036). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20226948..20282651. It has the cytological map location 96A1-96A2. Based on sequence similarity, it is predicted to have molecular function</span>: nicotinic acetylcholine-activated cation-selective channel activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ion transport. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 567 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    postsynaptic membrane [IEA]
    integral to membrane [IEA]
    nicotinic acetylcholine-gated receptor-channel complex [ISS]
    Biological Process: ion transport [IEA]
    Molecular Function: nicotinic acetylcholine-activated cation-selective channel activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSVLFAAVF IALHFATGGL ANPDAKRLYD DLLSNYNRLI RPVGNNSDRL TVKMGLRLSQ  60
   61 LIDVNLKNQI MTTNVWVEQE WNDYKLKWNP DDYGGVDTLH VPSEHIWLPD IVLYNNADGN 120
  121 YEVTIMTKAI LHHTGKVVWK PPAIYKSFCE IDVEYFPFDE QTCFMKFGSW TYDGYMVDLR 180
  181 HLKQTADSDN IEVGIDLQDY YISVEWDIMR VPAVRNEKFY SCCEEPYLDI VFNLTLRRKT 240
  241 LFYTVNLIIP CVGISFLSVL VFYLPSDSGE KISLCISILL SLTVFFLLLA EIIPPTSLTV 300
  301 PLLGKYLLFT MMLVTLSVVV TIAVLNVNFR SPVTHRMAPW VQRLFIQILP KLLCIERPKK 360
  361 EEPEEDQPPE VLTDVYHLPP DVDKFVNYDS KRFSGDYGIP ALPASHRFDL AAAGGISAHC 420
  421 FAEPPLPSSL PLPGADDDLF SPSGLNGDIS PGCCPAAAAA AAADLSPTFE KPYAREMEKT 480
  481 IEGSRFIAQH VKNKDKFESV EEDWKYVAMV LDRMFLWIFA IACVVGTALI ILQAPSLYDQ 540
  541 SQPIDILYSK IAKKKFELLK MGSENTL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..337] PSI-BLAST 80.045757 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [338..567] PSI-BLAST 41.522879 Acetylcholine receptor protein, beta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • acetylcholine binding
    		•  13.9752632471881 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  13.7533645836795 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  13.1511875247796 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  11.9525876011069 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  11.7813202122163 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  11.7813202122163 bayes_pls_golite062009
  • cation channel activity
    		•  11.7442066737514 bayes_pls_golite062009
  • ion channel activity
    		•  11.1753684044644 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  11.0903806681397 bayes_pls_golite062009
  • channel activity
    		•  11.0903806681397 bayes_pls_golite062009
  • gated channel activity
    		•  11.0397691626728 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  10.9375522860542 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • amine binding
    		•  9.11982124959723 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  9.10587892909341 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  7.22265353460749 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  7.19173677417054 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  6.7875346065164 bayes_pls_golite062009
  • transporter activity
    		•  5.11262082564788 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  5.03439798256257 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.91314874981447 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.50066216027179 bayes_pls_golite062009
  • receptor activity
    		•  4.29130501016821 bayes_pls_golite062009
  • neurotransmitter binding
    		•  4.25797760547212 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  4.15404686068319 bayes_pls_golite062009
  • signal transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • adenylate cyclase binding
    		•  3.30190657223613 bayes_pls_golite062009
  • binding
    		•  2.4916526322278 bayes_pls_golite062009
  • beta-amyloid binding
    		•  2.25766805801029 bayes_pls_golite062009
    		• 1.68370717591127 bayes_pls_golite062009
  • channel regulator activity
    		•  1.66978990310631 bayes_pls_golite062009
  • protein binding
    		•  1.45740893920165 bayes_pls_golite062009
  • serotonin binding
    		•  1.33584589886834 bayes_pls_golite062009
  • serotonin-activated cation-selective channel activity
    		•  1.31324203158511 bayes_pls_golite062009
  • toxin binding
    		•  1.03329843925063 bayes_pls_golite062009
  • drug binding
    		•  0.53275410807921 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.417103731247281 bayes_pls_golite062009
  • kinase binding
    		•  0.365355763029699 bayes_pls_golite062009
  • protein kinase binding
    		•  0.350601457777817 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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