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Protein Overview: Rox8-PC, Rox8-PB

General Information:
Name(s) found: Rox8-PC / FBpp0083979 [FlyBase]
Rox8-PB / FBpp0083977 [FlyBase]
Description(s) found:
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  • gi|7301091|gb|AAF56225.1| Rox8, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|7301090|gb|AAF56224.1| Rox8, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|24649517|ref|NP_732944.1| Rox8, isoform F [Drosophila melanogaster] [NCBI NR]
  • gi|24649515|ref|NP_732943.1| Rox8, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|24649513|ref|NP_732942.1| Rox8, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|23172125|gb|AAN13977.1| Rox8, isoform F [Drosophila melanogaster] [NCBI NR]
  • The gene Rox8 is referred to in FlyBase by the symbol Dmel\Rox8 (CG5422, FBgn0005649). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19868924..19873987. It has the cytological map location 95D9-95D10. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: regulation of alternative nuclear mRNA splicing, via spliceosome. 15 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG5422-PB translation from_gene[CG5422 Rox8 FBgn0005649] seq_release:3 mol_weight=49561 cds_boundaries:(3R:19,860,346..19,862,044[-]) aa_length:464 transcript_info:[CG5422-RB seq_release:3] gene_info:[gene symbol:Rox8 FBgn0005649 gene_boundaries:(3R:1 [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG5422-PF translation from_gene[CG5422 Rox8 FBgn0005649] seq_release:3 mol_weight=49561 cds_boundaries:(3R:19,860,346..19,862,044[-]) aa_length:464 transcript_info:[CG5422-RF seq_release:3] gene_info:[gene symbol:Rox8 FBgn0005649 gene_boundaries:(3R:1 [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG5422-PC translation from_gene[CG5422 Rox8 FBgn0005649] seq_release:3 mol_weight=49561 cds_boundaries:(3R:19,860,346..19,862,044[-]) aa_length:464 transcript_info:[CG5422-RC seq_release:3] gene_info:[gene symbol:Rox8 FBgn0005649 gene_boundaries:(3R:1 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VCE3) CG5422-PB (CG5422-PC) [DrosMelano7227.FASTAC.txt]
  • (AE003746) Rox8 gene product [alt 1] [Drosophila melanogaster] [yeastflysequest.fasta]
  • (AE003746) Rox8 gene product [alt 2] [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5422-PF, isoform F [Drosophila melanogaster]gi|7301090|gb|AAF56224.1| CG5422-PC, isoform C [Drosophila melanogaster]gi|7301091|gb|AAF56225.1| CG5422-PB, isoform B [Drosophila melanogaster]gi|24649517|ref|NP_732944.1| CG5422-PF [Drosophila melanogaste [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083977; name=Rox8-PB; parent=FBgn0005649,FBtr0084592; dbxref=FlyBase:FBpp0083977,FlyBase_Annotation_IDs:CG5422-PB,GB_protein:AAF56225.1,R [fly-100309-contam.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083978; name=Rox8-PF; parent=FBgn0005649,FBtr0084593; dbxref=FlyBase:FBpp0083978,FlyBase_Annotation_IDs:CG5422-PF,GB_protein:AAN13977.1,R [fly-100309-contam.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083979; name=Rox8-PC; parent=FBgn0005649,FBtr0084594; dbxref=FlyBase:FBpp0083979,FlyBase_Annotation_IDs:CG5422-PC,GB_protein:AAF56224.1,R [fly-100309-contam.fasta]
  • CG5422-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG5422-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Rox8 CG5422-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG5422-PF, isoform F [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Rox8 CG5422-PF, isoform F [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Rox8 CG5422-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083977; name=Rox8-PB; parent=FBgn0005649,FBtr0084592; dbxref=FlyBase:FBpp0083977,FlyBase_Annotation_IDs:CG5422-PB,GB_protein:AAF56225.1,REFSEQ:NP_732942,GB_protein:AAF56225; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083978; name=Rox8-PF; parent=FBgn0005649,FBtr0084593; dbxref=FlyBase:FBpp0083978,FlyBase_Annotation_IDs:CG5422-PF,GB_protein:AAN13977.1,REFSEQ:NP_732944,GB_protein:AAN13977; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083979; name=Rox8-PC; parent=FBgn0005649,FBtr0084594; dbxref=FlyBase:FBpp0083979,FlyBase_Annotation_IDs:CG5422-PC,GB_protein:AAF56224.1,REFSEQ:NP_732943,GB_protein:AAF56224; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083977; name=Rox8-PB; parent=FBgn0005649,FBtr0084592; dbxref=FlyBase:FBpp0083977,FlyBase_Annotation_IDs:CG5422-PB,GB_protein:AAF56225.1,REFSEQ:NP_732942,GB_protein:AAF56225; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083978; name=Rox8-PF; parent=FBgn0005649,FBtr0084593; dbxref=FlyBase:FBpp0083978,FlyBase_Annotation_IDs:CG5422-PF,GB_protein:AAN13977.1,REFSEQ:NP_732944,GB_protein:AAN13977; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083979; name=Rox8-PC; parent=FBgn0005649,FBtr0084594; dbxref=FlyBase:FBpp0083979,FlyBase_Annotation_IDs:CG5422-PC,GB_protein:AAF56224.1,REFSEQ:NP_732943,GB_protein:AAF56224; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Rox8, isoform B OS=Drosophila melanogaster GN=Rox8 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083977; name=Rox8-PB; parent=FBgn0005649,FBtr0084592; dbxref=FlyBase:FBpp0083977,FlyBase_Annotation_IDs:CG5422-PB,GB_protein:AAF56225.1,REFSEQ:NP_732942,GB_protein:AAF56225,FlyMine:FBpp0083977,modMine:FBpp0083977; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(19869686..19869849,19869919..19870012,19870080..19870988,19871160..19871387); ID=FBpp0083979; name=Rox8-PC; parent=FBgn0005649,FBtr0084594; dbxref=FlyBase:FBpp0083979,FlyBase_Annotation_IDs:CG5422-PC,GB_protein:AAF56224.1,REFSEQ:NP_732943,GB_protein:AAF56224; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(24045438..24045665,24044358..24045266,24044197..24044290,24043964..24044127)); ID=FBpp0083977; name=Rox8-PB; parent=FBgn0005649,FBtr0084592; dbxref=FlyBase:FBpp0083977,FlyBase_Annotation_IDs:CG5422-PB,GB_protein:AAF56225.1,REFSEQ:NP_732942,GB_protein:AAF56225,FlyMine:FBpp0083977,modMine:FBpp0083977; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(24045438..24045665,24044358..24045266,24044197..24044290,24043964..24044127)); ID=FBpp0083979; name=Rox8-PC; parent=FBgn0005649,FBtr0084594; dbxref=FlyBase:FBpp0083979,FlyBase_Annotation_IDs:CG5422-PC,GB_protein:AAF56224.1,REFSEQ:NP_732943,GB_protein:AAF56224; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(24045438..24045665,24044358..24045266,24044197..24044290,24043964..24044127)); ID=FBpp0083977; name=Rox8-PB; parent=FBgn0005649,FBtr0084592; dbxref=FlyBase:FBpp0083977,FlyBase_Annotation_IDs:CG5422-PB,GB_protein:AAF56225.1,REFSEQ:NP_732942,GB_protein:AAF56225,FlyMine:FBpp0083977,modMine:FBpp0083977; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3R:complement(join(24045438..24045665,24044358..24045266,24044197..24044290,24043964..24044127)); ID=FBpp0083979; name=Rox8-PC; parent=FBgn0005649,FBtr0084594; dbxref=FlyBase:FBpp0083979,FlyBase_Annotation_IDs:CG5422-PC,GB_protein:AAF56224.1,REFSEQ:NP_732943,GB_protein:AAF56224; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q8IMX4, Rox8, isoform B OS=Drosophila melanogaster GN=Rox8 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0083977 type=protein; loc=3R:complement(join(24045438..24045665,24044358..24045266,24044197..24044290,24043964..24044127)); ID=FBpp0083977; name=Rox8-PB; parent=FBgn0005649,FBtr0084592; dbxref=FlyBase:FBpp0083977,FlyBase_Annotation_IDs:CG5422-PB,GB_protein:AAF56225.1,REFSEQ:NP_732942,GB_protein:AAF56225,FlyMine:FBpp0083977,modMine:FBpp0083977; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0083979 type=protein; loc=3R:complement(join(24045438..24045665,24044358..24045266,24044197..24044290,24043964..24044127)); ID=FBpp0083979; name=Rox8-PC; parent=FBgn0005649,FBtr0084594; dbxref=FlyBase:FBpp0083979,FlyBase_Annotation_IDs:CG5422-PC,GB_protein:AAF56224.1,REFSEQ:NP_732943,GB_protein:AAF56224; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(24045438..24045665,24044358..24045266,24044197..24044290,24043964..24044127)); ID=FBpp0083977; name=Rox8-PB; parent=FBgn0005649,FBtr0084592; dbxref=FlyBase:FBpp0083977,FlyBase_Annotation_IDs:CG5422-PB,GB_protein:AAF56225.1,REFSEQ:NP_732942,GB_protein:AAF56225,UniProt/TrEMBL:Q9VCE3,FlyMine:FBpp0083977,modMine:FBpp0083977; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3R:complement(join(24045438..24045665,24044358..24045266,24044197..24044290,24043964..24044127)); ID=FBpp0083979; name=Rox8-PC; parent=FBgn0005649,FBtr0084594; dbxref=FlyBase:FBpp0083979,FlyBase_Annotation_IDs:CG5422-PC,GB_protein:AAF56224.1,REFSEQ:NP_732943,GB_protein:AAF56224,UniProt/TrEMBL:Q9VCE3; MD5=24d5b75ca7a784c58746cc4fbee7f3e5; length=464; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 464 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    U1 snRNP [ISS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    nuclear mRNA splicing, via spliceosome [ISS]
    Molecular Function: nucleotide binding [IEA]
    nucleic acid binding [IEA]
    poly(A) RNA binding [NAS]
    mRNA binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDESQPKTLY VGNLDSSVSE DLLIALFSTM GPVKSCKIIR EPGNDPYAFI EYSNYQAATT  60
   61 ALTAMNKRLF LEKEIKVNWA TSPGNQPKTD ISSHHHIFVG DLSPEIETET LREAFAPFGE 120
  121 ISNCRIVRDP HTMKSKGYAF VSFVKKAEAE NAIQAMNGQW IGSRSIRTNW STRKLPPPRE 180
  181 PSKGGGQGGG MGGGPGNGSG VKGSQRHTFE EVYNQSSPTN TTVYCGGFPP NVISDDLMHK 240
  241 HFVQFGPIQD VRVFKDKGFS FIKFVTKEAA AHAIEHTHNS EVHGNLVKCF WGKENGGDNS 300
  301 ANNLNAAAAA AAASANVAAV AAANAAVAAG AGMPGQMMTQ QQIAAATGAA IPGQMMTPQQ 360
  361 IAAQYPYAYQ QMGYWYPPAT YPTTQMQTQY MQQGYYPYAY PTSAQQAGGV PAGYRMVPPN 420
  421 VAWGVPGTVV PGVTAAAASA AAAANGSLAP QMMYSAAMPQ YQTQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] PSI-BLAST 48.30103 Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
    2 View Details [84..302] PSI-BLAST 13.69897 Polypyrimidine tract-binding protein
    3 View Details [303..464] PSI-BLAST 5.045757 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • U1 snRNA binding
    		•  4.22094068431436 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • DNA binding
    		•  1.8021593476478 bayes_pls_golite062009
  • structural molecule activity
    		•  1.56454315220334 bayes_pls_golite062009
  • U2 snRNA binding
    		•  1.34078165372485 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription factor activity
    		•  0.873765500321315 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
    2
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • U1 snRNA binding
    		•  4.22094068431436 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • DNA binding
    		•  1.8021593476478 bayes_pls_golite062009
  • structural molecule activity
    		•  1.56454315220334 bayes_pls_golite062009
  • U2 snRNA binding
    		•  1.34078165372485 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription factor activity
    		•  0.873765500321315 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.29

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle