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View Structure Prediction Details

Protein: Rox8-PC, Rox8-PB
Organism: Drosophila melanogaster
Length: 464 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Rox8-PC, Rox8-PB.

Description E-value Query
Range
Subject
Range
gi|73976803 - gi|73976803|ref|XP_857821.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
313.0 [0..8] [463..100]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDESQPKTLY VGNLDSSVSE DLLIALFSTM GPVKSCKIIR EPGNDPYAFI EYSNYQAATT  60
   61 ALTAMNKRLF LEKEIKVNWA TSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.30103
Match: 1pgzA
Description: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
U1 snRNA binding 4.22094068431436 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
structural molecule activity 1.56454315220334 bayes_pls_golite062009
U2 snRNA binding 1.34078165372485 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 0.873765500321315 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [84-302]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNQPKTDISS HHHIFVGDLS PEIETETLRE AFAPFGEISN CRIVRDPHTM KSKGYAFVSF  60
   61 VKKAEAENAI QAMNGQWIGS RSIRTNWSTR KLPPPREPSK GGGQGGGMGG GPGNGSGVKG 120
  121 SQRHTFEEVY NQSSPTNTTV YCGGFPPNVI SDDLMHKHFV QFGPIQDVRV FKDKGFSFIK 180
  181 FVTKEAAAHA IEHTHNSEVH GNLVKCFWGK ENGGDNSAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1qm9A
Description: Polypyrimidine tract-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
U1 snRNA binding 4.22094068431436 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
structural molecule activity 1.56454315220334 bayes_pls_golite062009
U2 snRNA binding 1.34078165372485 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 0.873765500321315 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [303-464]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLNAAAAAAA ASANVAAVAA ANAAVAAGAG MPGQMMTQQQ IAAATGAAIP GQMMTPQQIA  60
   61 AQYPYAYQQM GYWYPPATYP TTQMQTQYMQ QGYYPYAYPT SAQQAGGVPA GYRMVPPNVA 120
  121 WGVPGTVVPG VTAAAASAAA AANGSLAPQM MYSAAMPQYQ TQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.045757
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

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