Protein Overview: orb-PE, orb-PC

General Information:
Name(s) found:	orb-PE / FBpp0099607 [FlyBase] orb-PC / FBpp0083778 [FlyBase]
Description(s) found: Found 33 descriptions. SHOW ALL	The gene oo18 RNA-binding protein is referred to in FlyBase by the symbol Dmel\orb (CG10868, FBgn0004882). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19090364..19106571. It has the cytological map location 94E9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: oocyte anterior/posterior axis specification; regulation of oskar mRNA translation; mRNA polyadenylation; pole plasm oskar mRNA localization; germ cell development; oocyte dorsal/ventral axis specification. 30 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; chorion; embryonic abdomen; egg; ovary; oocyte; egg chamber; dorsal appendage; synaptonemal complex. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase] The gene oo18 RNA-binding protein is referred to in FlyBase by the symbol Dmel\orb (CG10868, FBgn0004882). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19090364..19106571. It has the cytological map location 94E9. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: oocyte anterior/posterior axis specification; regulation of oskar mRNA translation; mRNA polyadenylation; pole plasm oskar mRNA localization; germ cell development; oocyte dorsal/ventral axis specification. 30 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; chorion; embryonic abdomen; egg; ovary; oocyte; egg chamber; dorsal appendage; synaptonemal complex. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	559 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	germ cell development [IMP][TAS] positive regulation of translation [TAS] intracellular mRNA localization [TAS] germarium-derived oocyte fate determination [TAS] oocyte dorsal/ventral axis specification [IMP][TAS] embryonic axis specification [TAS] pole plasm assembly [NAS] mRNA polyadenylation [IMP][ISS] oocyte anterior/posterior axis specification [IMP][TAS] oocyte axis specification [TAS] oogenesis [TAS] regulation of oskar mRNA translation [IMP][TAS] pole plasm oskar mRNA localization [IMP][NAS][TAS] germ-line cyst formation [TAS] positive regulation of oskar mRNA translation [NAS]
Molecular Function:	nucleotide binding [IEA] protein binding [IPI] uridine-rich cytoplasmic polyadenylylation element binding [ISS] mRNA binding [ISS][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKVLRVNLL SVNSNKIPHQ QQQQQQQQQQ QQQQQQQNQQ QLQVQQQHQL QQQFVNLNRN  60
   61 YEQQISANLG SQQHGFEHNG VGVGASSSGN ENCFSQYNLE NITSVDMELA KLQNLQRINT 120
  121 LKLLHAQAQQ MPLINQLLQS YAGNAIGSVG GSNLGNLMSA GGSSLMTEMA GNVGGIITTN 180
  181 DGHLDRVAKF YKSSAALCDA TCTWSGHLPP RSHRMLNYSP KVFLGGIPWD ISEQSLIQIF 240
  241 KPFGSIKVEW PGKEQQAAQP KGYVYIIFES DKQVKALLSA CVLQVDDSHC GRNYFFKISS 300
  301 RRIKSKDVEV IPWIIADSNF VRSSSQKLDP TKTVFVGALH GKLTAEGLGN IMDDLFDGVL 360
  361 YAGIDTDKYK YPIGSGRVTF SNFRSYMKAV SAAFIEIRTT KFTKKVQVDP YLEDALCSIC 420
  421 GVQHGPYYCR ELSCFRYFCR SCWQWQHSCD IVKNHKPLTR NSKSQSLVGI GPSSSNVSLP 480
  481 FSGQRSIRDN RMGNGQHQQH QQHQYQQQKH RQLQEYSQPH SLNVMGNSGA ANAAATSMVT 540
  541 LQQRQIHKVR IQRQQHQAI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
RNA binding	4.63987691433124	bayes_pls_golite062009
nucleic acid binding	3.64594243387558	bayes_pls_golite062009
mRNA binding	3.54495985180603	bayes_pls_golite062009
binding	3.00411894202318	bayes_pls_golite062009
protein binding	2.17260848225967	bayes_pls_golite062009
	1.71820051628117	bayes_pls_golite062009
single-stranded RNA binding	1.46469774223879	bayes_pls_golite062009
poly-pyrimidine tract binding	0.862661444935922	bayes_pls_golite062009
transcription regulator activity	0.737458867828906	bayes_pls_golite062009
DNA binding	0.691258294213766	bayes_pls_golite062009
mRNA 3'-UTR binding	0.599389001184667	bayes_pls_golite062009
translation regulator activity	0.38120065819101	bayes_pls_golite062009
sequence-specific DNA binding	0.366758605553422	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.128616879457381	bayes_pls_golite062009
transcription activator activity	0.119266921032347	bayes_pls_golite062009
structural molecule activity	0.0829058000493267	bayes_pls_golite062009

Term	Confidence	Notes
RNA binding	4.63987691433124	bayes_pls_golite062009
nucleic acid binding	3.64594243387558	bayes_pls_golite062009
mRNA binding	3.54495985180603	bayes_pls_golite062009
binding	3.00411894202318	bayes_pls_golite062009
protein binding	2.17260848225967	bayes_pls_golite062009
	1.71820051628117	bayes_pls_golite062009
single-stranded RNA binding	1.46469774223879	bayes_pls_golite062009
poly-pyrimidine tract binding	0.862661444935922	bayes_pls_golite062009
transcription regulator activity	0.737458867828906	bayes_pls_golite062009
DNA binding	0.691258294213766	bayes_pls_golite062009
mRNA 3'-UTR binding	0.599389001184667	bayes_pls_golite062009
translation regulator activity	0.38120065819101	bayes_pls_golite062009
sequence-specific DNA binding	0.366758605553422	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.128616879457381	bayes_pls_golite062009
transcription activator activity	0.119266921032347	bayes_pls_golite062009
structural molecule activity	0.0829058000493267	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.85

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..208]	PSI-BLAST	35.69897	Poly(A)-binding protein
2	View Details	[209..416]	PSI-BLAST	42.522879	Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
3	View Details	[417..559]	PSI-BLAST	5.045757	Sec24

Protein Overview: orb-PE, orb-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: