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Protein Overview: FBpp0306674, Nrx...

General Information:
Name(s) found: FBpp0306674 [FlyBase]
Nrx-1-PA / FBpp0083649 [FlyBase]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • type=protein; loc=3R:join(18296207..18297112,18297241..18297717,18297783..18298094,18298159..18298275,18298331..18298715,18298791..18299161,18299360..18299471,18303802..18303949,18304010..18304767,18304825..18305175,18305252..18305487,18306518..18306848,18308569..18309578); ID=FBpp0306674; name=Nrx-1-PC; parent=FBgn0038975,FBtr0334607; dbxref=FlyBase:FBpp0306674,FlyBase_Annotation_IDs:CG7050-PC,REFSEQ:NP_001262837,GB_protein:AGB96217; MD5=384e8796f27602f9da37eeb138af4804; length=1837; release=r5.56; species=Dmel; [FlyBase]
  • The gene Neurexin 1 is referred to in FlyBase by the symbol Dmel\Nrx-1 (CG7050, FBgn0038975). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18294258..18309680. It has the cytological map location 94A16-94B1. Its molecular function is unknown. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1837 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [NAS]
    Biological Process: synapse organization [IDA]
    synaptic transmission [IDA]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAPHSATYQ DNYADAAMTA RTRPSMDMDQ QRNRNQAELR LLPAQRTSTS AFESPDLRFN  60
   61 KARRRRRSEQ VPPVVVEYRR SYRVLIVSAL LVSLAASFVT LSAGFQLDGS QNSFYTFRKW 120
  121 YTGLNGTLEL EFKTEQPNGL VLYTDDGGTY DFFELKLVEG ALRLRYNLGG GAQIITVGRE 180
  181 LHDGHWHKVQ VLRNDEQTSL IVDGVSQQRS TKGKEFQFGK FASNSDVYVG GMPNWYSSKL 240
  241 ALLALPSVIF EPRFRGAIRN LVYADQPGGS TRRQEIKQQR DIKCGDVPCD HGELPARERP 300
  301 LRGVRGGNTT DACERNDPCQ HGGICISTDS GPICECRNLE YDGQYCEKEK APSEATFRGT 360
  361 QFLSYDLGQT GAEPIVSAQD AISFYFRTRQ PNGLLFYTGH GTDYLNLALR DGGVSLTMGL 420
  421 ANGKQEMHIK PSKVRFDDHQ WHKVTVHRRI QEISSITSFC RLVTVVDDVY TDHSHIAGKF 480
  481 TMLSSSRVYV GGAVNPRALL GARVHTNFVG CLRKVEFSAD TLNLNLIDLA KSGSKLIQVA 540
  541 GNLEYQCPSG DPQDPVTFTT RESHLVLPPW ETGKQSSISF KFRTKEPNGI IVLATGSKQP 600
  601 RAKNPVLIAI ELLNGHIYIH LDLGSGASKV RASRRRVDDG DWHDLILRRN GRDAKVSVDG 660
  661 VWNDFRTPGD GTILELDGHM YLGGVGPAYN SVSWPAAIWT ATLRQGFVGC LRDLVLSGKA 720
  721 IDIAAFARVQ DSASVKPSCH VQANVCNGNP CLNGGTCLEG WNRPICDCSA TLYGGPTCGR 780
  781 ELATLAFNGS QHMTIWLGNG QGTKTQTEEL VIRFKTSRPA GLLLLTSAES NSPDRLEIAL 840
  841 VAGRVRASVR LSDREKNLLA GQSVLNDNNW HTIRFSRRAS NLRLQVDGAP PVRAETILGR 900
  901 HSTMEIRSVH LGGLFHAEEE IQMTSTMPNF VGQMQGLVFN GQRYLDIVKS LGPELSALPS 960
  961 ATFKLTARFV NSPAGQPYHA ATFRSKHSYV GLAMLKAYNS ISIDFRFKTV EPNGLLVFNG1020
 1021 GRRNDFVAVE LVNGHIHYTF DLGDGPVTMR DKSRIHMNDN RWHQVSIRRP GPKTHTLTVD1080
 1081 DSFEIISLTG NNMHLELAGI LYIGGVFKDM YSKLPASISS RSGFEGCLAS LDLGDASPSL1140
 1141 TSDAVVPSSL VVSGCEGPTK CSQNACANRG NCVQQWNAYA CECDMTSYTG PTCYDESIAY1200
 1201 EFGNNKGMVQ YTFPENAQAD TEEDNIALGF ITTRPDAVLL RVESATTQDY MELEIVEGNI1260
 1261 FMVYNIGSVD LPLGEIGTKV NDNAYHVVRF QRKGGNATLQ LDDYNVQALT PQSHHSTVFN1320
 1321 TMSNVQVGGK FSRNGRNRIE RPFAGVIAGL SVNKLRILDL AVERDPHITI RGDVQLVTGV1380
 1381 LDRNDLQRMQ QTPASGYPGA LDDLIFSGAG SGCRGDDEDE CTPPFESGSG DDLITPVYVP1440
 1441 PTKQTTTSQQ GNSLSTGGSS SGGVITNGTE RACDDEDCVH GSGDYGETTE QFTSTSTARG1500
 1501 SESNNEMVTI TTTGRSDVTT EQHQGSSSSS SSGSTPSYAT TQSSSSSSSG GSAASTPGQV1560
 1561 STTSSVATSS TQRATSSSTS TSSSTTSTTT TTTTTQATPP PEIRSTVTER ETTPYDIYIA1620
 1621 GGGMGGSGRN DHDRMQLPDE HHPLPPLPPP IPPQDPPPYG PYGGNTYNTN MNNYRPKGKG1680
 1681 GRINSIEEER TAMIIGIVAG ILIAVVLVIL LVLWLKSNGD RGYKTESEKA AAYGSHNPNA1740
 1741 ALLGNTSTNG SYHQQRQHHM HGGGGGGGAG QQQHHAQQQM HNGHNGNGNG GGGGGGGMMS1800
 1801 SGSGSLGYGS DGRPQMAGLV QPKAKKRDSK DVKEWYV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..255] PSI-BLAST 8.69897 Sex hormone-binding globulin
    3 View Details [256..336] FFAS03 2.2 NMR structure of the human NOTCH-1 ligand binding region
    4 View Details [337..559] PSI-BLAST 31.69897 No description for 2h0bA was found.
    5 View Details [560..770] PSI-BLAST 4.69897 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    6 View Details [771..1191] PSI-BLAST 51.39794 No description for 2jd4A was found.
    7 View Details [1192..1428] PSI-BLAST 24.69897 Ligand-binding domain of neurexin 1beta
    8 View Details [1429..1521] deduced N/A No confident structure predictions are available.
    9 View Details [1522..1769] MSA 2.144996 View MSA. No confident structure predictions are available.
    10 View Details [1770..1837] FFAS03 1.09 Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • calcium channel regulator activity
    		•  3.29698499133819 bayes_pls_golite062009
  • binding
    		•  1.56259855231916 bayes_pls_golite062009
  • signal transducer activity
    		•  1.51337551419779 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.51337551419779 bayes_pls_golite062009
  • transporter activity
    		•  1.29150662073327 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07075219961504 bayes_pls_golite062009
  • receptor activity
    		•  0.84237246159117 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801327928563072 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.701946977691471 bayes_pls_golite062009
  • protein binding
    		•  0.657665757061848 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.546870122670733 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.419551733755705 bayes_pls_golite062009
  • sugar binding
    		•  0.280170040829765 bayes_pls_golite062009
  • acetylcholine receptor regulator activity
    		•  0.197294628885479 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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