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View Structure Prediction Details

Protein: FBpp0306674, Nrx...
Organism: Drosophila melanogaster
Length: 1837 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0306674, Nrx....

Description E-value Query
Range		 Subject
Range
Nrx-1-PB, FBpp03... - The gene Neurexin 1 is referred to in FlyBase by the symbol Dmel\Nrx-1 (CG7050, FBgn0038975). It is ...
 1021.0 [0..1] [1837..1]

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Predicted Domain #1
Region A:
Residues: [1-93] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAPHSATYQ DNYADAAMTA RTRPSMDMDQ QRNRNQAELR LLPAQRTSTS AFESPDLRFN  60
   61 KARRRRRSEQ VPPVVVEYRR SYRVLIVSAL LVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [94-255] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAASFVTLSA GFQLDGSQNS FYTFRKWYTG LNGTLELEFK TEQPNGLVLY TDDGGTYDFF  60
   61 ELKLVEGALR LRYNLGGGAQ IITVGRELHD GHWHKVQVLR NDEQTSLIVD GVSQQRSTKG 120
  121 KEFQFGKFAS NSDVYVGGMP NWYSSKLALL ALPSVIFEPR FR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1kdkA
Description: Sex hormone-binding globulin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [256-336] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAIRNLVYAD QPGGSTRRQE IKQQRDIKCG DVPCDHGELP ARERPLRGVR GGNTTDACER  60
   61 NDPCQHGGIC ISTDSGPICE C

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.2
Match: 1tozA
Description: NMR structure of the human NOTCH-1 ligand binding region
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [337-559] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNLEYDGQYC EKEKAPSEAT FRGTQFLSYD LGQTGAEPIV SAQDAISFYF RTRQPNGLLF  60
   61 YTGHGTDYLN LALRDGGVSL TMGLANGKQE MHIKPSKVRF DDHQWHKVTV HRRIQEISSI 120
  121 TSFCRLVTVV DDVYTDHSHI AGKFTMLSSS RVYVGGAVNP RALLGARVHT NFVGCLRKVE 180
  181 FSADTLNLNL IDLAKSGSKL IQVAGNLEYQ CPSGDPQDPV TFT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.69897
Match: 2h0bA
Description: No description for 2h0bA was found.

Predicted Domain #5
Region A:
Residues: [560-770] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TRESHLVLPP WETGKQSSIS FKFRTKEPNG IIVLATGSKQ PRAKNPVLIA IELLNGHIYI  60
   61 HLDLGSGASK VRASRRRVDD GDWHDLILRR NGRDAKVSVD GVWNDFRTPG DGTILELDGH 120
  121 MYLGGVGPAY NSVSWPAAIW TATLRQGFVG CLRDLVLSGK AIDIAAFARV QDSASVKPSC 180
  181 HVQANVCNGN PCLNGGTCLE GWNRPICDCS A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [771-1191] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLYGGPTCGR ELATLAFNGS QHMTIWLGNG QGTKTQTEEL VIRFKTSRPA GLLLLTSAES  60
   61 NSPDRLEIAL VAGRVRASVR LSDREKNLLA GQSVLNDNNW HTIRFSRRAS NLRLQVDGAP 120
  121 PVRAETILGR HSTMEIRSVH LGGLFHAEEE IQMTSTMPNF VGQMQGLVFN GQRYLDIVKS 180
  181 LGPELSALPS ATFKLTARFV NSPAGQPYHA ATFRSKHSYV GLAMLKAYNS ISIDFRFKTV 240
  241 EPNGLLVFNG GRRNDFVAVE LVNGHIHYTF DLGDGPVTMR DKSRIHMNDN RWHQVSIRRP 300
  301 GPKTHTLTVD DSFEIISLTG NNMHLELAGI LYIGGVFKDM YSKLPASISS RSGFEGCLAS 360
  361 LDLGDASPSL TSDAVVPSSL VVSGCEGPTK CSQNACANRG NCVQQWNAYA CECDMTSYTG 420
  421 P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 2jd4A
Description: No description for 2jd4A was found.

Predicted Domain #7
Region A:
Residues: [1192-1428] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TCYDESIAYE FGNNKGMVQY TFPENAQADT EEDNIALGFI TTRPDAVLLR VESATTQDYM  60
   61 ELEIVEGNIF MVYNIGSVDL PLGEIGTKVN DNAYHVVRFQ RKGGNATLQL DDYNVQALTP 120
  121 QSHHSTVFNT MSNVQVGGKF SRNGRNRIER PFAGVIAGLS VNKLRILDLA VERDPHITIR 180
  181 GDVQLVTGVL DRNDLQRMQQ TPASGYPGAL DDLIFSGAGS GCRGDDEDEC TPPFESG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 1c4rA
Description: Ligand-binding domain of neurexin 1beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
calcium channel regulator activity 3.29698499133819 bayes_pls_golite062009
binding 1.56259855231916 bayes_pls_golite062009
signal transducer activity 1.51337551419779 bayes_pls_golite062009
molecular transducer activity 1.51337551419779 bayes_pls_golite062009
transporter activity 1.29150662073327 bayes_pls_golite062009
transmembrane transporter activity 1.07075219961504 bayes_pls_golite062009
receptor activity 0.84237246159117 bayes_pls_golite062009
substrate-specific transporter activity 0.801327928563072 bayes_pls_golite062009
transmembrane receptor activity 0.701946977691471 bayes_pls_golite062009
protein binding 0.657665757061848 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.546870122670733 bayes_pls_golite062009
carbohydrate binding 0.419551733755705 bayes_pls_golite062009
sugar binding 0.280170040829765 bayes_pls_golite062009
acetylcholine receptor regulator activity 0.197294628885479 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1429-1521] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGDDLITPVY VPPTKQTTTS QQGNSLSTGG SSSGGVITNG TERACDDEDC VHGSGDYGET  60
   61 TEQFTSTSTA RGSESNNEMV TITTTGRSDV TTE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1522-1769] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHQGSSSSSS SGSTPSYATT QSSSSSSSGG SAASTPGQVS TTSSVATSST QRATSSSTST  60
   61 SSSTTSTTTT TTTTQATPPP EIRSTVTERE TTPYDIYIAG GGMGGSGRND HDRMQLPDEH 120
  121 HPLPPLPPPI PPQDPPPYGP YGGNTYNTNM NNYRPKGKGG RINSIEEERT AMIIGIVAGI 180
  181 LIAVVLVILL VLWLKSNGDR GYKTESEKAA AYGSHNPNAA LLGNTSTNGS YHQQRQHHMH 240
  241 GGGGGGGA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1770-1837] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQQQHHAQQQ MHNGHNGNGN GGGGGGGGMM SSGSGSLGYG SDGRPQMAGL VQPKAKKRDS  60
   61 KDVKEWYV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.09
Match: 1yx4A
Description: Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle