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Protein Overview: TFAM-PB

General Information:
Name(s) found: TFAM-PB / FBpp0083356 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene mitochondrial transcription factor A is referred to in FlyBase by the symbol Dmel\TFAM (CG4217, FBgn0038805). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16401073..16402741. It has the cytological map location 92F2. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: positive regulation of transcription, DNA-dependent. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 284 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    mitochondrion [IDA][ISS][NAS]
    Biological Process: positive regulation of transcription, DNA-dependent [ISS]
    mitochondrial DNA replication [NAS]
    regulation of transcription [NAS]
    Molecular Function: transcription factor activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIYTTTLMSS RGGLIGSLIN KVRQVVAKDW PPSDPSRAND TDHRPLTPPR PLAAASISNT  60
   61 PAVPSKTLEE QLGLPPRPKK PLTPYFRFMR EQRPKLKAAN PQITTVEVVR QLSKNWSDAD 120
  121 AQLKERLQAE FKRDQQIYVE ERTKYDATLT EEQRAEIKQL KQDLVDAKER RQLRKRVKEL 180
  181 GRPKKPASAF LRFIASERIN TPQGDKQTYR EWHQKTTAKW TRLSDSEKEV YMQESRKEME 240
  241 LYRKAISVWE EKMIRLGHID VVRHGNLIDP PEPKPRKTLA SKDI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..284] PSI-BLAST 24.39794 No description for 2gzkA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  4.56243042026586 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.42927972796404 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.36244161599487 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.55724742149483 bayes_pls_golite062009
  • transcription factor activity
    		•  3.28411755496908 bayes_pls_golite062009
  • binding
    		•  3.1918149935012 bayes_pls_golite062009
  • transcription activator activity
    		•  2.44785103043103 bayes_pls_golite062009
  • protein binding
    		•  2.18211240370246 bayes_pls_golite062009
  • transcription factor binding
    		•  1.46324768909727 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.34004089271327 bayes_pls_golite062009
  • chromatin binding
    		•  1.323916832561 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.04044219600834 bayes_pls_golite062009
  • DNA bending activity
    		•  0.41929067872099 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.32807045001653 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle