YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Gyc-89Db-PA

General Information:
Name(s) found: Gyc-89Db-PA / FBpp0082745 [FlyBase]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • The gene Guanylyl cyclase at 89Db is referred to in FlyBase by the symbol Dmel\Gyc-89Db (CG14886, FBgn0038436). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12303093..12306794. It has the cytological map location 89B18. There is experimental evidence that it has the molecular function</span>: guanylate cyclase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: cGMP biosynthetic process; intracellular signaling cascade. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: guanylate cyclase complex, soluble [ISS]
    Biological Process: cGMP biosynthetic process [IEA]
    intracellular signaling pathway [IEA]
    Molecular Function: guanylate cyclase activity [IDA][ISS]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYGMLYESVQ HYIQQEYGME TWRKVCQIVD CKHQSFKTHQ IYPDKLMPDF AAALSASTGE  60
   61 SFDFCMNFFG RCFVRFFSNF GYDKMIRSTG RYFCDFLQSI DNIHVQMRFT YPKMKSPSMQ 120
  121 LTNMDDDGAV ILYRSGRTGM SKYLIGQMTE VAKEFYGLDM TAYVLESQND ICGGTAGPIK 180
  181 LTEGPLTVIV KYRLDFDNRD YMAKRVNVIA HPSQLKMPSV DLNVFLELFP FTIVLDHDMK 240
  241 ITLAGEKIVE TWILHNPGVN PKTFIGSHIL ERFKCRRPKD TQIQWETILQ MRTVLFEFEL 300
  301 IRTGHNRAAY DAALNFDFEN FDEASSLNEA QAMALASAKE FSAENAKEEA AAAATSKDEI 360
  361 DPATGQRRHS VGLRSILLKG QMFYIKDVDS LIFLCSPLIE NLDELHGIGL YLNDLNPHGL 420
  421 SRELVMAGWQ HCSKLEIMFE KEEQRSDELE KSLELADSWK RQGDELLYSM IPRPIAERMR 480
  481 KSEEHVCQSF EEVSVIFIEV MNIYDSGSNN IQDAMQAVTT LNKVFSALDE EIISPFVYKV 540
  541 ETVGMVYMAV SGAPDVNPLH AEHACDLALR VMKKVKAHAL PGVAIRVGIN SGPVVAGVVG 600
  601 MKVPRYCLFG DTVNTASRME SSSDPWMIQL SNYTALKVQK VGYKVEARGF VKVKGKGEME 660
  661 TYWLLEGPE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] PSI-BLAST 42.39794 No description for 2o09A was found.
    2 View Details [185..442] PSI-BLAST 3.69897 Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain
    3 View Details [443..669] PSI-BLAST 50.0 Crystal structure of a mutant form of the mycobacterial adenylyl cyclase Rv1625c

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • guanylate cyclase activity
    		•  5.52874578464122 bayes_pls_golite062009
  • cyclase activity
    		•  4.4495441728539 bayes_pls_golite062009
  • phosphorus-oxygen lyase activity
    		•  4.17797478360781 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.27819936906601 bayes_pls_golite062009
  • kinase activity
    		•  3.03163710008327 bayes_pls_golite062009
  • protein kinase activity
    		•  2.8660447961069 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.74029785568283 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  2.59466621605752 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • binding
    		•  2.10874590528357 bayes_pls_golite062009
  • transferase activity
    		•  1.80001061545783 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.01447477827105 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.01441566554376 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.0012255632847 bayes_pls_golite062009
  • nucleotide binding
    		•  0.989402689682387 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  0.734194601335452 bayes_pls_golite062009
  • ATP binding
    		•  0.59909499260393 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.574651252033402 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.553738346856309 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.369966838509407 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.289778841954859 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.269647063625821 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.264291916981806 bayes_pls_golite062009
  • DNA binding
    		•  0.210479525543021 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle