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Protein Overview: mus309-PA

General Information:
Name(s) found: mus309-PA / FBpp0081910 [FlyBase]
Description(s) found:
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  • gi|7299503|gb|AAF54691.1| mutagen-sensitive 309 [Drosophila melanogaster] [NCBI NR]
  • gi|24646066|ref|NP_524319.2| mutagen-sensitive 309 [Drosophila melanogaster] [NCBI NR]
  • gi|17366114|sp|Q9VGI8.1|BLM_DROME RecName: Full=Bloom syndrome protein homolog; Short=Dmblm; AltName: Full=Mutagen-sensitive protein 309; AltName: Full=RecQ helicase homolog [NCBI NR]
  • Bloom syndrome protein homolog OS=Drosophila melanogaster GN=Blm PE=1 SV=1 [Swiss-Prot]
  • The gene mutagen-sensitive 309 is referred to in FlyBase by the symbol Dmel\mus309 (CG6920, FBgn0002906). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7562053..7567505. It has the cytological map location 86E17. There is experimental evidence that it has the molecular function</span>: DNA strand annealing activity; Y-form DNA binding; ATP-dependent 3'-5' DNA helicase activity; DNA-dependent ATPase activity. There is experimental evidence that it is involved in the biological process</span>: reciprocal meiotic recombination; DNA duplex unwinding; double-strand break repair via synthesis-dependent strand annealing; response to DNA damage stimulus; strand displacement; double-strand break repair; DNA synthesis during DNA repair; double-strand break repair via homologous recombination. 13 alleles are reported. The phenotype of these alleles is annotated with: dorsal mesothoracic disc. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG6920-PA translation from_gene[CG6920 mus309 FBgn0002906] seq_release:3 mol_weight=166080 cds_boundaries:(3R:7,562,769..7,567,397[-]) aa_length:1487 transcript_info:[CG6920-RA seq_release:3] gene_info:[gene symbol:mus309 FBgn0002906 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VGI8) Bloom's syndrome protein homolog (EC 3.6.1.-) (Dmblm) (Mutagen-sensitive protein 309) (RecQ helicase homolog) [DrosMelano7227.FASTAC.txt]
  • (AE003692) blm gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG6920-PA [Drosophila melanogaster]gi|24646066|ref|NP_524319.2| CG6920-PA [Drosophila melanogaster]gi|17366114|sp|Q9VGI8|BLM_DROME Bloom's syndrome protein homolog (Dmblm) (Mutagen-sensitive protein 309) (RecQ helicase homolog) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(7562748..7563985,7564041..7564863,7564927..7567235,7567286..7567379); ID=FBpp0081910; name=mus309-PA; parent=FBgn0002906,FBtr0082434; dbxref=FlyBase:FBpp0081910,FlyBase_Annotation_IDs:CG6920-PA,GB_protein:AAF54691.1,REFSEQ: [fly-100309-contam.fasta]
  • mutagen-sensitive 309 CG6920-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG6920-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Bloom syndrome protein homolog (Dmblm) (Mutagen-sensitive protein 309) (RecQ helicase homolog) [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(7562748..7563985,7564041..7564863,7564927..7567235,7567286..7567379); ID=FBpp0081910; name=mus309-PA; parent=FBgn0002906,FBtr0082434; dbxref=FlyBase:FBpp0081910,FlyBase_Annotation_IDs:CG6920-PA,GB_protein:AAF54691.1,REFSEQ:NP_524319,GB_protein:AAF54691; MD5=05089244c4caff9d0c50ef36c8cba3a0; length=1487; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(7562748..7563985,7564041..7564863,7564927..7567235,7567286..7567379); ID=FBpp0081910; name=mus309-PA; parent=FBgn0002906,FBtr0082434; dbxref=FlyBase:FBpp0081910,FlyBase_Annotation_IDs:CG6920-PA,GB_protein:AAF54691.1,REFSEQ:NP_524319,GB_protein:AAF54691; MD5=05089244c4caff9d0c50ef36c8cba3a0; length=1487; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Bloom syndrome protein homolog OS=Drosophila melanogaster GN=mus309 PE=1 SV=1 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta]
  • type=protein; loc=3R:complement(7562748..7563985,7564041..7564863,7564927..7567235,7567286..7567379); ID=FBpp0081910; name=mus309-PA; parent=FBgn0002906,FBtr0082434; dbxref=FlyBase:FBpp0081910,FlyBase_Annotation_IDs:CG6920-PA,GB_protein:AAF54691.1,REFSEQ:NP_524319,GB_protein:AAF54691,FlyMine:FBpp0081910,modMine:FBpp0081910; MD5=05089244c4caff9d0c50ef36c8cba3a0; length=1487; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(11741564..11741657,11739205..11741513,11738319..11739141,11737026..11738263)); ID=FBpp0081910; name=Blm-PA; parent=FBgn0002906,FBtr0082434; dbxref=FlyBase:FBpp0081910,FlyBase_Annotation_IDs:CG6920-PA,GB_protein:AAF54691.1,REFSEQ:NP_524319,GB_protein:AAF54691,FlyMine:FBpp0081910,modMine:FBpp0081910; MD5=05089244c4caff9d0c50ef36c8cba3a0; length=1487; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(11741564..11741657,11739205..11741513,11738319..11739141,11737026..11738263)); ID=FBpp0081910; name=Blm-PA; parent=FBgn0002906,FBtr0082434; dbxref=FlyBase:FBpp0081910,FlyBase_Annotation_IDs:CG6920-PA,GB_protein:AAF54691.1,REFSEQ:NP_524319,GB_protein:AAF54691,FlyMine:FBpp0081910,modMine:FBpp0081910; MD5=05089244c4caff9d0c50ef36c8cba3a0; length=1487; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0081910 type=protein; loc=3R:complement(join(11741564..11741657,11739205..11741513,11738319..11739141,11737026..11738263)); ID=FBpp0081910; name=Blm-PA; parent=FBgn0002906,FBtr0082434; dbxref=FlyBase:FBpp0081910,FlyBase_Annotation_IDs:CG6920-PA,GB_protein:AAF54691.1,REFSEQ:NP_524319,GB_protein:AAF54691,FlyMine:FBpp0081910,modMine:FBpp0081910; MD5=05089244c4caff9d0c50ef36c8cba3a0; length=1487; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(11741564..11741657,11739205..11741513,11738319..11739141,11737026..11738263)); ID=FBpp0081910; name=Blm-PA; parent=FBgn0002906,FBtr0082434; dbxref=FlyBase:FBpp0081910,FlyBase_Annotation_IDs:CG6920-PA,GB_protein:AAF54691.1,REFSEQ:NP_524319,GB_protein:AAF54691,UniProt/Swiss-Prot:Q9VGI8,FlyMine:FBpp0081910,modMine:FBpp0081910; MD5=05089244c4caff9d0c50ef36c8cba3a0; length=1487; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1487 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: reciprocal meiotic recombination [IMP]
    DNA replication [IEA]
    DNA duplex unwinding [IDA]
    double-strand break repair via homologous recombination [IMP]
    double-strand break repair via synthesis-dependent strand annealing [IMP]
    strand displacement [IDA]
    response to DNA damage stimulus [IGI][IMP]
    DNA synthesis involved in DNA repair [IMP]
    double-strand break repair [IMP]
    Molecular Function: ATP binding [IEA]
    DNA helicase activity [ISS]
    DNA-dependent ATPase activity [IDA]
    DNA strand annealing activity [IDA]
    ATP-dependent 3'-5' DNA helicase activity [IDA]
    helicase activity [ISS]
    Y-form DNA binding [IDA]
    ATP-dependent DNA helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKKPVAQRK QLTLSSFIGL DGNSQSQPKS RAASVRSKPP AVYNPIFLDA SSSDDETTEI  60
   61 SSQSNNGTIA TKKSSRDPRT AKLKKHTYLD LSVSPLAKLS AKKYARDSPK KPTSLDLSVS 120
  121 PLAELLAKKS DRDSPKKPVQ NENSYTYRGL SESPVENKSI GDTLRKPPQK ERKTSIVWLS 180
  181 DSPEKKVTQN ERKILDSPLQ RFSFEDFPNK ENGNRHHLLT LPDSPPPPQP VKKPEKTMWQ 240
  241 NETKTIQDKD SPANPLVSNN LASISTLLDS SRAPNTYKGS SRNLFEDSPE KSGSGEQGYK 300
  301 LGSAKENEIP TKPATASLER NSVTSSPSPA APLKPRYSVA FDNSLADYLK DLAQNDNFSI 360
  361 DPNKQNTETL KSTLGFFRNT YVELMEKYCS LIDQIPAMHF NEIAGFQPNT FLKLKVMRQK 420
  421 FKARTQLVQN SLDKKESQLK AEQEALEKEE IEMQAEQAQQ TVLSSSSPEK SRPIMPLPKV 480
  481 QEIKDEKIPN RNQLIHDLCG EPDNFSPPSS PRDTQLIPKR QQLINDLCGE PDDFSPPSKQ 540
  541 NDPHLLRKCE ELVHDLCEEP DDYLAQSMML DGDLEEEQLN GPTQGTTTSG MDDDEDDLEG 600
  601 LLAEIEDEHQ KMQGRRSEFN GYSYKELEAV KVKEKHKETP INISLDDDGF PEYDEAMFEQ 660
  661 MHSQAAANKS RVSSAGPSTS KSVVPTKQTS ALHSQKLSGN FHANVHNDGI TGEFDGQKFE 720
  721 HSTRLMHGLS YSFGLKSFRP NQLQVINATL LGNDCFVLMP TGGGKSLCYQ LPAILTEGVT 780
  781 IVISPLKSLI FDQINKLASL DICAKSLSGE QKMADVMAIY RDLESQPPMV KLLYVTPEKI 840
  841 SSSARFQDTL DTLNSNNYIS RFVIDEAHCV SQWGHDFRPD YKKLGVLKKR FPNVPTIALT 900
  901 ATATPRVRLD ILAQLNLKNC KWFLSSFNRS NLRYRVLPKK GVSTLDDISR YIRSKPQHFS 960
  961 GIIYCLSRKE CDETSKKMCK DGVRAVSYHA GLTDTDRESR QKDWLTGKMR VICATVAFGM1020
 1021 GIDKPDVRFV LHYSLPKSIE GYYQEAGRAG RDGDVADCIL YYNYSDMLRI KKMLDSDKAL1080
 1081 QYNVKKIHVD NLYRIVGYCE NLTDCRRAQQ LDYFGEHFTS EQCLENRETA CDNCINKRAY1140
 1141 KAVDALEHAR KAARAVKDLC SGRSRFTLLH IADVLKGSKI KKIIDFNHHK TPHHGVLKDW1200
 1201 DKNDVHRLLR KMVIDGFLRE DLIFTNDFPQ AYLYLGNNIS KLMEGTPNFE FAVTKNAKEA1260
 1261 KAAVGSVSDG ATSSTADGQS GMREIHERCY TDLLDLCRTI ASQRNVTMAS IMNIQALKSM1320
 1321 AETLPITEKD MCSIPHVTKA NFDKYGAKLL EITSNYASEK LLMQAVLDEE EEQAAAKQRP1380
 1381 STSGWNNESV DWDMAVASQG NANTSGASGF NSFRAGKRKK IYKSGASKRY KTSTTSPAAR1440
 1441 KTTSARGRGG RAGAKRAESS ASSASGWKSK KTGNSFGFDL MPLPGSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] deduced N/A No confident structure predictions are available.
    2 View Details [80..233] MSA 1.252988 View MSA. No confident structure predictions are available.
    3 View Details [234..485] MSA 1.263996 View MSA. No confident structure predictions are available.
    4 View Details [486..669] deduced N/A No confident structure predictions are available.
    5 View Details [670..1277] PSI-BLAST 121.0 No description for 2v1xA was found.
    6 View Details [1278..1360] PSI-BLAST 22.39794 E. coli RecQ HRDC domain
    7 View Details [1361..1487] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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