Protein Overview: hyd-PA

General Information:
Name(s) found:	hyd-PA / FBpp0081568 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|68844926\|sp\|P51592.3\|HYD_DROME RecName: Full=E3 ubiquitin-protein ligase hyd; AltName: Full=Protein hyperplastic discs [NCBI NR] gi\|24645474\|ref\|NP_524296.2\| hyperplastic discs [Drosophila melanogaster] [NCBI NR] gi\|23170838\|gb\|AAF54431.2\| hyperplastic discs [Drosophila melanogaster] [NCBI NR] E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 [Swiss-Prot] The gene hyperplastic discs is referred to in FlyBase by the symbol Dmel\hyd (CG9484, FBgn0002431). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5540344..5551333. It has the cytological map location 85E5. Based on sequence similarity, it is predicted to have molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: female gonad development; imaginal disc development; eye-antennal disc morphogenesis; imaginal disc growth; spermatogenesis. 42 alleles are reported. The phenotypes of these alleles are annotated with: dorsal mesothoracic disc; ovary; testis; dorsal metathoracic disc; imaginal disc. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG9484-PA translation from_gene[CG9484 hyd FBgn0002431] seq_release:3 mol_weight=318884 cds_boundaries:(3R:5,540,693..5,551,263[-]) aa_length:2885 transcript_info:[CG9484-RA seq_release:3] gene_info:[gene symbol:hyd FBgn0002431 gene_boundaries:(3R:5,5 [hmr_yeast5_DM3-1_pombe.fasta] CG9484-PA [Drosophila melanogaster]gi\|24645474\|ref\|NP_524296.2\| CG9484-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3R:complement(5540674..5540886,5540946..5541176,5541243..5541390,5541446..5541652,5541713..5542038,5542096..5542172,5542239..5543195,5543252..5543998,5544053..5544263,5544353..5544825,5544886..5545119,5545199..5545343,5545442..5548942,55 [fly-100309-contam.fasta] CG9484-PA [Drosophila melanogaster] [nr-271106-contam.fasta] Ubiquitin--protein ligase hyd (Protein hyperplastic discs) [nr-271106-contam.fasta] hyperplastic discs CG9484-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3R:complement(5540674..5540886,5540946..5541176,5541243..5541390,5541446..5541652,5541713..5542038,5542096..5542172,5542239..5543195,5543252..5543998,5544053..5544263,5544353..5544825,5544886..5545119,5545199..5545343,5545442..5548942,5549030..5549220,5549283..5549521,5549582..5549799,5549859..5550138,5550202..5550399,5551186..5551247); ID=FBpp0081568; name=hyd-PA; parent=FBgn0002431,FBtr0082090; dbxref=FlyBase:FBpp0081568,FlyBase_Annotation_IDs:CG9484-PA,GB_protein:AAF54431.2,REFSEQ:NP_524296,GB_protein:AAF54431; MD5=098b4ad4f62b8d0afb93830bc7a68f40; length=2885; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:complement(5540674..5540886,5540946..5541176,5541243..5541390,5541446..5541652,5541713..5542038,5542096..5542172,5542239..5543195,5543252..5543998,5544053..5544263,5544353..5544825,5544886..5545119,5545199..5545343,5545442..5548942,5549030..5549220,5549283..5549521,5549582..5549799,5549859..5550138,5550202..5550399,5551186..5551247); ID=FBpp0081568; name=hyd-PA; parent=FBgn0002431,FBtr0082090; dbxref=FlyBase:FBpp0081568,FlyBase_Annotation_IDs:CG9484-PA,GB_protein:AAF54431.2,REFSEQ:NP_524296,GB_protein:AAF54431; MD5=098b4ad4f62b8d0afb93830bc7a68f40; length=2885; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3R:complement(5540674..5540886,5540946..5541176,5541243..5541390,5541446..5541652,5541713..5542038,5542096..5542172,5542239..5543195,5543252..5543998,5544053..5544263,5544353..5544825,5544886..5545119,5545199..5545343,5545442..5548942,5549030..5549220,5549283..5549521,5549582..5549799,5549859..5550138,5550202..5550399,5551186..5551247); ID=FBpp0081568; name=hyd-PA; parent=FBgn0002431,FBtr0082090; dbxref=FlyBase:FBpp0081568,FlyBase_Annotation_IDs:CG9484-PA,GB_protein:AAF54431.2,REFSEQ:NP_524296,GB_protein:AAF54431,FlyMine:FBpp0081568,modMine:FBpp0081568; MD5=098b4ad4f62b8d0afb93830bc7a68f40; length=2885; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:complement(join(9725464..9725525,9724480..9724677,9724137..9724416,9723860..9724077,9723561..9723799,9723308..9723498,9719720..9723220,9719477..9719621,9719164..9719397,9718631..9719103,9718331..9718541,9717530..9718276,9716517..9717473,9716374..9716450,9715991..9716316,9715724..9715930,9715521..9715668,9715224..9715454,9714952..9715164)); ID=FBpp0081568; name=hyd-PA; parent=FBgn0002431,FBtr0082090; dbxref=FlyBase:FBpp0081568,FlyBase_Annotation_IDs:CG9484-PA,GB_protein:AAF54431.2,REFSEQ:NP_524296,GB_protein:AAF54431,FlyMine:FBpp0081568,modMine:FBpp0081568; MD5=098b4ad4f62b8d0afb93830bc7a68f40; length=2885; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:complement(join(9725464..9725525,9724480..9724677,9724137..9724416,9723860..9724077,9723561..9723799,9723308..9723498,9719720..9723220,9719477..9719621,9719164..9719397,9718631..9719103,9718331..9718541,9717530..9718276,9716517..9717473,9716374..9716450,9715991..9716316,9715724..9715930,9715521..9715668,9715224..9715454,9714952..9715164)); ID=FBpp0081568; name=hyd-PA; parent=FBgn0002431,FBtr0082090; dbxref=FlyBase:FBpp0081568,FlyBase_Annotation_IDs:CG9484-PA,GB_protein:AAF54431.2,REFSEQ:NP_524296,GB_protein:AAF54431,FlyMine:FBpp0081568,modMine:FBpp0081568; MD5=098b4ad4f62b8d0afb93830bc7a68f40; length=2885; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0081568 type=protein; loc=3R:complement(join(9725464..9725525,9724480..9724677,9724137..9724416,9723860..9724077,9723561..9723799,9723308..9723498,9719720..9723220,9719477..9719621,9719164..9719397,9718631..9719103,9718331..9718541,9717530..9718276,9716517..9717473,9716374..9716450,9715991..9716316,9715724..9715930,9715521..9715668,9715224..9715454,9714952..9715164)); ID=FBpp0081568; name=hyd-PA; parent=FBgn0002431,FBtr0082090; dbxref=FlyBase:FBpp0081568,FlyBase_Annotation_IDs:CG9484-PA,GB_protein:AAF54431.2,REFSEQ:NP_524296,GB_protein:AAF54431,FlyMine:FBpp0081568,modMine:FBpp0081568; MD5=098b4ad4f62b8d0afb93830bc7a68f40; length=2885; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:complement(join(9725464..9725525,9724480..9724677,9724137..9724416,9723860..9724077,9723561..9723799,9723308..9723498,9719720..9723220,9719477..9719621,9719164..9719397,9718631..9719103,9718331..9718541,9717530..9718276,9716517..9717473,9716374..9716450,9715991..9716316,9715724..9715930,9715521..9715668,9715224..9715454,9714952..9715164)); ID=FBpp0081568; name=hyd-PA; parent=FBgn0002431,FBtr0082090; dbxref=FlyBase:FBpp0081568,FlyBase_Annotation_IDs:CG9484-PA,GB_protein:AAF54431.2,REFSEQ:NP_524296,GB_protein:AAF54431,UniProt/Swiss-Prot:P51592,FlyMine:FBpp0081568,modMine:FBpp0081568; MD5=098b4ad4f62b8d0afb93830bc7a68f40; length=2885; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2885 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS] cytoplasm [IDA]
Biological Process:	germ cell development [NAS] spermatogenesis [IMP] regulation of proteolysis [NAS] protein modification process [IEA] imaginal disc development [IMP][NAS] eye-antennal disc morphogenesis [IMP] female gonad development [IMP] negative regulation of smoothened signaling pathway [NAS] compound eye development [NAS] regulation of cell proliferation [NAS] imaginal disc growth [IMP]
Molecular Function:	ubiquitin-protein ligase activity [ISS][NAS] zinc ion binding [IEA] RNA binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSMQFVLQP LPGSDDQFIE RIREVSDKVN RFGYGSHRIF EQLKIPVKEV VIGPAHIGVL  60
   61 LEDGKAFRVS FSINSEKLDL TKSDAKCSTS GGSGTASASK APSSSRPMAR SRARLLRATG 120
  121 RSNSTGQGSG SRSTGVIIGG STSSRPLVTV PATYVPEELI SQAEVVLQGK SRNLIIRELQ 180
  181 RTNLDVNLAV NNLLSRDDEE AEDTEEGADN YVPEDLISLL DNGFSGDNNS VIIDPSDGLF 240
  241 SEEIFSNYSS IRNLLFDRIR SERSNANANA ADSNQSTTRS TSSGTALTGN SGLSAQISVN 300
  301 ADREAFSRWR DRQYYGPRRW ISKDDYTWEK DADSKKKEPS PMLSPIWISE ELQPWPEKSS 360
  361 VRFKTIGALY SEFIALSESG DLYQWRWSDA EPYKSETENV YHPKTVSLNI VERVELISAN 420
  421 FIRCSVVTET NRVATWMDEQ LGYIGAKLEH SCCAFNEFIS DSITKIYVCS LYTVVKTESN 480
  481 NIYWWGVLPF DQRRFLWDKF RTKTKKPFKV VATDINVGAQ VIMKKCPMYQ SGSIGFTCSN 540
  541 GVPKVGQLLN SVWTFTDVCR MKIININTNS GVDKSQAAGN NLNAHGITPD KDLPKSTAMP 600
  601 STGSSKNGQS FSNSKESTDR IDMPPPPSPA SSTCSDTGSV TSHKRTKRAT TKEDSNAPQE 660
  661 GRKDEELWEV KDVVFVEDKV GPVGKVLKVD GDFVAVRFPA INAAAVAAAA AATSSTSNTA 720
  721 STSKEEGKED DWQQCRLLRR EDVQIFRTAM STRGPDWLQK QPKKINVGGD AAGAQILTLA 780
  781 VDSRGIHVIK KVLGKIHYSL YNLYNCKQEQ NCLFPTDCNS FIGSTPGNIL MACNDDCSGN 840
  841 SSTIVLRDGN GALYPLAKDC LGSIKDPQWF DLPPVKSITM STISLPAMLS GVNLKSKVCM 900
  901 TALLFDTQKL MPHILRCDVK NSFAALGRLE REDQADTALV VEERCDGARN IFHACVIMCA 960
  961 PSSNKDSPPD SPSGGVEKKS LVGLSVARSI PTVSTSAYVS SIAFGASASS SNENSSFATM1020
 1021 SSSAAGSASS TSRDNRTNLR DMMNRLINSD QAEQSGSQPM ATNNEDHAYI PWPAETPAAS1080
 1081 NLSASSSQNV SDSIEDDISK IIPSSSQSSM LSNIKLGSPT YTFDLAQRRE HALTILQQMC1140
 1141 VSPALRPYLC HMLSTKDAQG QTPFMLSVSC RAYEAGIILL NTILMLSEQD PQLKEAMIFP1200
 1201 NGSPADQSPL HVICYNDTCS FTWTGADHIN QNIFECKTCG LTGSLCCCTE CARVCHKGHD1260
 1261 CKLKRTAPTA YCDCWEKCKC KALIAGNLTK RFALLCKLVS CTDLVTKFNS KGESILLFLI1320
 1321 QTVGRQIVEQ RQYRFSVRVR NVSTAATGAT GNNSVISNRK TSAAEIDNDM PDHDLEPPKF1380
 1381 ARKALERLLI DWNAVRSMIM SGAERGDVPN PAGSASENSN SEGFNMFIQT QHGSTLLDKF1440
 1441 THSLIVKCTS DHLDTLLLTL VRELQNASVS NRSKEAEEVV RRFVRSVARV FVIFNLEKQP1500
 1501 NPEKRKSHSS CNKYVQSCVK VFQTLHKISI EELCEVSEAL IAPVRLGVVR PTAPFTMSSS1560
 1561 NLDNSDDLFS VDPLAPSNVE SPSEQILVHD AGNDQSANFN IQQNYDVVAM ETIRDASESE1620
 1621 EVINREANSH NQDDELIENQ RNEDGMQDDE SDNDFTFNDA ETESDSDDNQ SNQEVQRSVQ1680
 1681 AGATVGSEND IGVLFLEDES GDSSAQEEDG SEDGESDDQS DEFNFNEQQL ERRSTNSNAR1740
 1741 SDLAPQTMQW AIRSRDTARS SVRVPTGSNM VFIDPMALRR STVPASTTVT TPSIEPHTMA1800
 1801 TTASNLARAF GITIRQISEL ISILSYNVLN DIETSLKIQN DEAIAVQAFV EKRLKATWDW1860
 1861 MFTVMDGTEA QLKFGAYLTN YTDPNHPLHP LNLSAQASSS QTPAPATSSS VNGVNIMGSN1920
 1921 SRRDFFTYCL SLMRSHTSEH RDALPVLDIT ALRHIAYVLD AFVYYMRNDS GFYDKQDTIS1980
 1981 GRINNLSPMT ESYDTDDELA NLEEFNADVQ MSASSMPSGS QGTRRHAFFA RSESTLSLGC2040
 2041 SAPEGFELPL DMAMPLADKP HLLQPNSKRQ ELFANLPLLV TTNANNSGAT NDGDGGSIFD2100
 2101 YTPTRLGFSN SLKRNERVYE TVPIDSSKTG DGNVTNKAEG STDSNIYVQL KKKQGSDDFK2160
 2161 SHKEADGNQS KYEKVVLMET DDSLPSTSKS TEALMATRPE VIIAPNKASV SPATAARSVI2220
 2221 VLAGGSCLKT IDSDINNYSA SNLSTAEQAK CDTQYQKSTS DHLLLFPARG SQFYQSNFSE2280
 2281 LPSWNFLLSR WKLTLDLFGR VFMDDVGMEH GSVLPELRGF PVKEMRFRRH MEKLRNGQQR2340
 2341 DLVLCKLERN RESLIVQTFK ELNTQFGNQS RRIQPPITFN RVKVTFKDEP GEGSGVARSF2400
 2401 YTSIAEALLA SAKIPNLESV QVGTNHSKYV VPFSSILRSR TVSGSSRDQS TLQRRGSNSK2460
 2461 ILWRSARERK ALNLDARPYT PPNSSDNATP ESLNDHLSVH LQQIGERLYP KIHSINQTHA2520
 2521 PKITGMLLEI PTPQLLSVIS SDETLRQKVN EAIEIITFKQ KSETSAQSSQ PKKSPSVVVV2580
 2581 DPVDDDNEPL FYSPGKRGFY TPRQGFASFE RINAFRNIGR LIGLCLLQNE LLPLFLQRHV2640
 2641 LKYILGRKIK FHDLAFFDPA LYESFRQIIQ NAQTKEGEET INRMELCFVI DLMKEEGCGN2700
 2701 RELIPGGRDV AVTSSNIFEY VRRYTEYRLI KSQEKALEAL KDGVFDVLPD NSMINLTAED2760
 2761 LRLLLNGVGD INVSTLISYT TFNDESSEGP DKLLKFKKWF WSIVEKMNIM ERQDLVYFWT2820
 2821 GSPALPASEE GFQPLPSVTI RPADDSHLPT ANTCISRLYI PLYSSKSILR SKMLMAIKSK2880
 2881 NFGFV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: hyd-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: