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Protein Overview: neur-PA

General Information:
Name(s) found: neur-PA / FBpp0081481 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene neuralized is referred to in FlyBase by the symbol Dmel\neur (CG11988, FBgn0002932). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4846068..4865189. It has the cytological map location 85C2-85C3. There is experimental evidence that it has the molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence for 16 unique biological process</span> terms, many of which group under: anatomical structure development; sensory organ development; organ development; organ morphogenesis; behavior; regulation of developmental process; regulation of biological process; locomotory behavior; regulation of neurogenesis; protein localization; neuromuscular process; behavioral interaction between organisms; response to chemical stimulus. 91 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: peripheral nervous system; adult segment; nervous system; embryonic nervous system; organ system; adult mesothoracic segment; external compound sense organ; embryonic glial cell; external sensory organ precursor cell; multi-cell-component structure. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 754 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    perinuclear region of cytoplasm [IDA]
    cytoplasm [IDA]
    plasma membrane [IDA]
    Biological Process: regulation of Notch signaling pathway [IMP]
    mesoderm development [IMP]
    nervous system development [IMP][NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    protein localization [IMP]
    peripheral nervous system development [IMP]
    regulation of compound eye photoreceptor development [IMP]
    asymmetric cell division [TAS]
    brain morphogenesis [IMP]
    ectoderm development [TAS]
    olfactory behavior [IMP]
    inter-male aggressive behavior [IMP]
    compound eye development [IMP][TAS]
    positive regulation of Notch signaling pathway [TAS]
    sensory organ development [IMP]
    locomotion involved in locomotory behavior [IMP]
    startle response [IMP]
    ovarian follicle cell development [TAS]
    sensory organ precursor cell fate determination [IMP]
    germ-line stem cell maintenance [IMP]
    Molecular Function: DNA binding [ISS]
    ubiquitin-protein ligase activity [IDA]
    zinc ion binding [IEA]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLSDIPANY MQGSHPHLTL HPQQQHHQNQ QHLQHLQQMQ QLHNAMPTPA QQAAQVLAME  60
   61 SNELLMSTKD KLSSKKKMHL LKKIKKRFGL VRRSPSSCPG PNNLPPLQFH SVHGDNIRIS 120
  121 RDGTLARRFE SFCRAITFSA RPVRINERIC VKFAEISNNW NGGIRFGFTS NDPVTLEGTL 180
  181 PKYACPDLTN RPGFWAKALH EQYCEKDNIL YYYVNGAGDV IYGINNEEKG VILTGIDTRS 240
  241 LLWTVIDIYG NCTGIEFLDS RIYMYQQQPA AIPMATVPAQ QQQMPQPAAN ASSALNSHHP 300
  301 HQQSRRSLPG HTAAIEHDLE RHVMPSLQSL HLAGNGGSVA SVEQAAIAHD LANGLPPLRY 360
  361 NANGRLIPVP FHNTKGRNVR LSQDRFVASR TESDFCQGYV FTARPIRIGE KLIVQVLKTE 420
  421 QMYVGALALG LTSCNPAMLQ PNDLPNDSDF LLDRPEYWVV SKDIAAAPQR GDEIAFFVAP 480
  481 NGEVSISKNN GPAVVVMHVD QSLQLWAFLD VYGSTQSLRM FRQQLPNMVA YPSQPQVNVN 540
  541 ASSSSACNAA STSRMLPMTE SMSSLNAGAT AKLLHHPSQL SVAQSTSTLA SAGGVNGSRM 600
  601 ISMPSNGDIL QIQPNGGGTV LVVNLPPASS SHDINGQLAA RPTATVTSSG VLAGACSSGT 660
  661 LISTTSSQYI EQPIANSTNN AANKWKDSLS DQQSTDSSAE CTICYENPID SVLYMCGHMC 720
  721 MCYDCAIEQW RGVGGGQCPL CRAVIRDVIR TYTT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..263] PSI-BLAST 63.522879 No description for 2yueA was found.
    3 View Details [264..338] deduced N/A No confident structure predictions are available.
    4 View Details [339..532] FFAS03 6.64 No description for 2yueA was found.
    5 View Details [533..629] deduced N/A No confident structure predictions are available.
    6 View Details [630..754] PSI-BLAST 6.09691 No description for 2cklB was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle