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Protein Overview: Prat-PA, FBpp0293248

General Information:
Name(s) found: FBpp0293248 [FlyBase]
Prat-PA / FBpp0081261 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=3R:complement(3735691..3737331); ID=FBpp0293248; name=Prat-PB; parent=FBgn0004901,FBtr0304705; dbxref=REFSEQ:NP_001246972,GB_protein:AFH06291,FlyBase:FBpp0293248,FlyBase_Annotation_IDs:CG2867-PB; MD5=09aac43e86eb4f3757a3b15035803e24; length=546; release=r5.56; species=Dmel; [FlyBase]
  • The gene Phosphoribosylamidotransferase is referred to in FlyBase by the symbol Dmel\Prat (CG2867, FBgn0004901). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:3735310..3737501. It has the cytological map location 84E5. There is experimental evidence that it has the molecular function</span>: amidophosphoribosyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan; embryonic cleavage; oogenesis. 11 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; oocyte; follicle cell; border follicle cell; egg chamber. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 546 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: embryonic cleavage [IMP]
    oogenesis [IMP]
    determination of adult lifespan [IMP]
    'de novo' IMP biosynthetic process [NAS]
    nucleoside metabolic process [IEA]
    purine base biosynthetic process [IEA][ISS]
    Molecular Function: amidophosphoribosyltransferase activity [IMP][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPQQQQQS QQKQQQHVRV VEQQQVEPAE AVTSSMESES ISASKELTGL THECGVFGAI  60
   61 ACGDWPTQMD IAHVICLGLV ALQHRGQESA GIATSEGKCS KNFNVHKGMG MISTLFNDDS 120
  121 MKKLRGNLGI GHTRYSTAGG SGVVNCQPFE VHTTHGALAL AHNGELVNNE SLRREVLARG 180
  181 VGLSTHSDSE LIAQSLCCAP EDVSELDGPN WPARIRHFMM LAPLSYSLVI MLKDKIYAVR 240
  241 DTYGNRPLCI GKIVPINAGH GNNLDTPADG WVVSSESCGF LSIGARYVRE VEPGEIVELS 300
  301 RSGYRTVDIV ERPDFKRMAF CIFEYVYFAR GDSIFEGQMV YTVRLQCGRQ LWREAPVEAD 360
  361 IVSSVPESGT AAAHGYARES GIEFAEVLCR NRYVGRTFIQ PSTRLRQLGV AKKFGALSEN 420
  421 VAGKRLVLID DSIVRGNTIG PIIKLLRDAG AREVHIRIAS PPLQYPCYMG INIPTREELI 480
  481 ANKLNPDQLA RHVGADSLAY LSVEGLVEAV QLKHRDAGDS KSKGTGHCTA CLTGEYPGGL 540
  541 PDELSW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..51] PSI-BLAST 50.39794 Alpha subunit of glutamate synthase, C-terminal domain; Alpha subunit of glutamate synthase, central and FMN domains; Alpha subunit of glutamate synthase, N-terminal domain
    2 View Details [52..546] PSI-BLAST 112.0 Glutamine PRPP amidotransferase, C-terminal domain; Glutamine PRPP amidotransferase, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • uracil phosphoribosyltransferase activity
    		•  2.36237864658341 bayes_pls_golite062009
  • ribose phosphate diphosphokinase activity
    		•  1.51875493459374 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • adenine phosphoribosyltransferase activity
    		•  0.985266832225609 bayes_pls_golite062009
  • diphosphotransferase activity
    		•  0.749909396904601 bayes_pls_golite062009
  • hypoxanthine phosphoribosyltransferase activity
    		•  0.625087274084001 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.283725923623827 bayes_pls_golite062009
  • ligase activity
    		•  0.204093345072151 bayes_pls_golite062009
  • orotate phosphoribosyltransferase activity
    		•  0.148898393751978 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.0940838340168359 bayes_pls_golite062009
  • peptidase activity
    		•  0.0898497842822991 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.057753538747651 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.012663147802059 bayes_pls_golite062009
  • protein binding
    		•  0.00621436730716318 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle