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Protein Overview: zen2-PA

General Information:
Name(s) found: zen2-PA / FBpp0081171 [FlyBase]
Description(s) found:
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  • gi|7298882|gb|AAF54088.1| zerknullt-related, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|68845291|sp|P09090.2|ZEN2_DROME RecName: Full=Protein zerknuellt 2; Short=ZEN-2 [NCBI NR]
  • gi|4389431|gb|AAD19801.1| DNA-binding-protein,transcription-factor [Drosophila melanogaster] [NCBI NR]
  • gi|17136604|ref|NP_476794.1| zerknullt-related, isoform A [Drosophila melanogaster] [NCBI NR]
  • Protein zerknuellt 2 OS=Drosophila melanogaster GN=zen2 PE=2 SV=2 [Swiss-Prot]
  • The gene zerknullt-related is referred to in FlyBase by the symbol Dmel\zen2 (CG1048, FBgn0004054). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2568854..2569862. It has the cytological map location 84A5. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: regulation of transcription, DNA-dependent. 15 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG1048-PA translation from_gene[CG1048 zen2 FBgn0004054] seq_release:3 mol_weight=29027 cds_boundaries:(3R:2,568,975..2,569,797[-]) aa_length:252 transcript_info:[CG1048-RA seq_release:3] gene_info:[gene symbol:zen2 FBgn0004054 gene_boundaries:(3R:2,5 [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003674) zen2 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG1048-PA [Drosophila melanogaster]gi|17136604|ref|NP_476794.1| CG1048-PA [Drosophila melanogaster]gi|4389431|gb|AAD19801.1| DNA-binding-protein,transcription-factor [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(2568971..2569669,2569737..2569796); ID=FBpp0081171; name=zen2-PA; parent=FBgn0004054,FBtr0081671; dbxref=FlyBase:FBpp0081171,FlyBase_Annotation_IDs:CG1048-PA,GB_protein:AAF54088.1,REFSEQ:NP_476794,GB_protein:AAF54088; MD5=d [fly-100309-contam.fasta]
  • zerknullt-related CG1048-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1048-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Protein zerknuellt 2 (ZEN-2) [nr-271106-contam.fasta]
  • DNA-binding-protein,transcription-factor [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(2568971..2569669,2569737..2569796); ID=FBpp0081171; name=zen2-PA; parent=FBgn0004054,FBtr0081671; dbxref=FlyBase:FBpp0081171,FlyBase_Annotation_IDs:CG1048-PA,GB_protein:AAF54088.1,REFSEQ:NP_476794,GB_protein:AAF54088; MD5=dbe168bb4d234576bb67a1f2e020fdb1; length=252; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(2568971..2569669,2569737..2569796); ID=FBpp0081171; name=zen2-PA; parent=FBgn0004054,FBtr0081671; dbxref=FlyBase:FBpp0081171,FlyBase_Annotation_IDs:CG1048-PA,GB_protein:AAF54088.1,REFSEQ:NP_476794,GB_protein:AAF54088; MD5=dbe168bb4d234576bb67a1f2e020fdb1; length=252; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:complement(2568971..2569669,2569737..2569796); ID=FBpp0081171; name=zen2-PA; parent=FBgn0004054,FBtr0081671; dbxref=FlyBase:FBpp0081171,FlyBase_Annotation_IDs:CG1048-PA,GB_protein:AAF54088.1,REFSEQ:NP_476794,GB_protein:AAF54088,FlyMine:FBpp0081171,modMine:FBpp0081171; MD5=dbe168bb4d234576bb67a1f2e020fdb1; length=252; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(6744015..6744074,6743249..6743947)); ID=FBpp0081171; name=zen2-PA; parent=FBgn0004054,FBtr0081671; dbxref=FlyBase:FBpp0081171,FlyBase_Annotation_IDs:CG1048-PA,GB_protein:AAF54088.1,REFSEQ:NP_476794,GB_protein:AAF54088,FlyMine:FBpp0081171,modMine:FBpp0081171; MD5=dbe168bb4d234576bb67a1f2e020fdb1; length=252; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(6744015..6744074,6743249..6743947)); ID=FBpp0081171; name=zen2-PA; parent=FBgn0004054,FBtr0081671; dbxref=FlyBase:FBpp0081171,FlyBase_Annotation_IDs:CG1048-PA,GB_protein:AAF54088.1,REFSEQ:NP_476794,GB_protein:AAF54088,FlyMine:FBpp0081171,modMine:FBpp0081171; MD5=dbe168bb4d234576bb67a1f2e020fdb1; length=252; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0081171 type=protein; loc=3R:complement(join(6744015..6744074,6743249..6743947)); ID=FBpp0081171; name=zen2-PA; parent=FBgn0004054,FBtr0081671; dbxref=FlyBase:FBpp0081171,FlyBase_Annotation_IDs:CG1048-PA,GB_protein:AAF54088.1,REFSEQ:NP_476794,GB_protein:AAF54088,FlyMine:FBpp0081171,modMine:FBpp0081171; MD5=dbe168bb4d234576bb67a1f2e020fdb1; length=252; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(6744015..6744074,6743249..6743947)); ID=FBpp0081171; name=zen2-PA; parent=FBgn0004054,FBtr0081671; dbxref=FlyBase:FBpp0081171,FlyBase_Annotation_IDs:CG1048-PA,GB_protein:AAF54088.1,REFSEQ:NP_476794,GB_protein:AAF54088,UniProt/Swiss-Prot:P09090,FlyMine:FBpp0081171,modMine:FBpp0081171; MD5=dbe168bb4d234576bb67a1f2e020fdb1; length=252; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 252 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: dorsal/ventral pattern formation, imaginal disc [NAS]
    regulation of transcription, DNA-dependent [IEA][ISS]
    regulation of transcription [IEA]
    Molecular Function: transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAIQSENYF VDNYSVSDLM MYPCVELNVE AAPTATTRSS EKSKRSRTAF SSLQLIELER  60
   61 EFHLNKYLAR TRRIEISQRL ALTERQVKIW FQNRRMKLKK STNRKGAIGA LTTSIPLSSQ 120
  121 SSEDLQKDDQ IVERLLRYAN TNVETAPLRQ VDHGVLEEGQ ITPPYQSYDY LHEFSPEPMA 180
  181 LPQLPFNEFD ANWASSWLGL EPTIPIAENV IEHNTQDQPM IQNFCWDSNS SSASSSDILD 240
  241 VDYDFIQNLL NF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 22.69897 Ultrabithorax (ubx) homeodomain
    2 View Details [109..252] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle