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View Structure Prediction Details

Protein: zen2-PA
Organism: Drosophila melanogaster
Length: 252 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for zen2-PA.

Description E-value Query
Range
Subject
Range
gi|807874 - gi|807874|emb|CAA48417.1| z2 [Drosophila sp.]
gi|123433, gi|280614 - pir||B43697 homeotic protein zen2 - fruit fly (Drosophila melanogaster), sp|P09090|HMZ2_DROME ZERKN...
161.0 [0..1] [252..1]
zen2-PB - The gene zerknullt-related is referred to in FlyBase by the symbol Dmel\zen2 (CG1048, FBgn0004054). ...
149.0 [0..21] [252..1]
OTX5_XENTR - Homeobox protein otx5 OS=Xenopus tropicalis GN=otx5 PE=2 SV=1
134.0 [0..12] [252..7]
gi|47230174 - gi|47230174|emb|CAG10588.1| unnamed protein product [Tetraodon nigroviridis]
133.0 [0..12] [252..63]
gi|115394172 - gi|115394172|gb|ABI97033.1| orthodenticle-related homeobox 5 [Gallus gallus]
133.0 [0..12] [252..7]
OTX5B_XENLA - Homeobox protein otx5-B OS=Xenopus laevis GN=otx5-b PE=2 SV=1
133.0 [0..12] [252..7]
gi|18091718 - gi|18091718|gb|AAK85128.1| homeobox protein Otx5 [Scyliorhinus canicula]
131.0 [0..12] [252..7]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAIQSENYF VDNYSVSDLM MYPCVELNVE AAPTATTRSS EKSKRSRTAF SSLQLIELER  60
   61 EFHLNKYLAR TRRIEISQRL ALTERQVKIW FQNRRMKLKK STNRKGAI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.69897
Match: 1b8iA
Description: Ultrabithorax (ubx) homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [109-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GALTTSIPLS SQSSEDLQKD DQIVERLLRY ANTNVETAPL RQVDHGVLEE GQITPPYQSY  60
   61 DYLHEFSPEP MALPQLPFNE FDANWASSWL GLEPTIPIAE NVIEHNTQDQ PMIQNFCWDS 120
  121 NSSSASSSDI LDVDYDFIQN LLNF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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