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Protein Overview: TfIIFalpha-PA

General Information:
Name(s) found: TfIIFalpha-PA / FBpp0081216 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Transcription factor IIFÃ?&#142;Ã?± is referred to in FlyBase by the symbol Dmel\TfIIFÃ?&#142;Ã?± (CG10281, FBgn0010282). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2206181..2208326. It has the cytological map location 83E5. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 577 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    transcription factor TFIIF complex [ISS][NAS]
    Biological Process: transcription from RNA polymerase II promoter [NAS]
    positive regulation of transcription [IEA]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: transcription initiation factor activity [NAS]
    DNA binding [IEA]
    catalytic activity [IEA]
    general RNA polymerase II transcription factor activity [ISS][NAS]
    transcription activator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSASKSTPS AASGSSTSAA AAAAASVASG SASSSANVQE FKIRVPKMPK KHHVMRFNAT  60
   61 LNVDFAQWRN VKLERENNMK EFRGMEEDQP KFGAGSEYNR DQREEARRKK FGIIARKYRP 120
  121 EAQPWILKVG GKTGKKFKGI REGGVGENAA FYVFTHAPDG AIEAYPLTEW YNFQPIQRYK 180
  181 SLSAEEAEQE FGRRKKVMNY FSLMLRKRLR GDEEEEQDPE EAKLIKAATK KSKELKITDM 240
  241 DEWIDSEDES DSEDEEDKKK KEQEDSDDGK AKGKGKKGAD KKKKKRDVDD EAFEESDDGD 300
  301 EEGREMDYDT SSSEDEPDPE AKVDKDMKGV AEEDALRKLL TSDEEEDDEK KSDESDKEDA 360
  361 DGEKKKKDKG KDEVSKDKKK KKPTKDDKKG KSNGSGDSST DFSSDSTDSE DDLSNGPPKK 420
  421 KVVVKDKDKE KEKEKESAAS SKVIASSSNA NKSRSATPTL STDASKRKMN SLPSDLTASD 480
  481 TSNSPTSTPA KRPKNEISTS LPTSFSGGKV EDYGITEEAV RRYLKRKPLT ATELLTKFKN 540
  541 KKTPVSSDRL VETMTKILKK INPVKHTIQG KMYLWIK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 38.30103 TFIIF alpha subunit, Rap74
    2 View Details [195..285] deduced N/A No confident structure predictions are available.
    3 View Details [286..463] MSA 1.158989 View MSA. No confident structure predictions are available.
    4 View Details [464..577] PSI-BLAST 11.0 C-terminal domain of the rap74 subunit of TFIIF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  0.835523092977445 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.4843036104266 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.37117756729668 bayes_pls_golite062009
  • DNA binding
    		•  0.3118855114645 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle