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Protein Overview: Pcmt-PA

General Information:
Name(s) found: Pcmt-PA / FBpp0078405 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • The gene Protein-L-isoaspartate (D-aspartate) O-methyltransferase is referred to in FlyBase by the symbol Dmel\Pcmt (CG2152, FBgn0086768). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1378545..1380033. It has the cytological map location 101F-83B1. There is experimental evidence that it has the molecular function</span>: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. It is reported to be involved in the biological process</span>: protein repair; protein modification process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 226 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    Biological Process: protein repair [NAS]
    protein modification process [IEA][NAS]
    Molecular Function: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWRSVGANN EDLIRQLKDH GVIASDAVAQ AMKETDRKHY SPRNPYMDAP QPIGGGVTIS  60
   61 APHMHAFALE YLRDHLKPGA RILDVGSGSG YLTACFYRYI KAKGVDADTR IVGIEHQAEL 120
  121 VRRSKANLNT DDRSMLDSGQ LLIVEGDGRK GYPPNAPYNA IHVGAAAPDT PTELINQLAS 180
  181 GGRLIVPVGP DGGSQYMQQY DKDANGKVEM TRLMGVMYVP LTDLRS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] PSI-BLAST 40.045757 Drosophila protein isoaspartyl methyltransferase with S-adenosyl-L-homocysteine

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein methyltransferase activity
    		•  5.03267617653315 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  4.4632173842967 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  3.97658336148086 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  3.26663548517117 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  3.26663548517117 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.86617323549909 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  2.48017990451667 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  2.46301422147246 bayes_pls_golite062009
  • protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
    		•  2.27866575945018 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.91133457052099 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  1.69391860928068 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  1.15089820497406 bayes_pls_golite062009
  • DNA binding
    		•  1.11249468705987 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08316818833182 bayes_pls_golite062009
  • binding
    		•  0.976078016260105 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.908932475461063 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  0.817509452491588 bayes_pls_golite062009
  • thiopurine S-methyltransferase activity
    		•  0.74333485845978 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.230719796976667 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle