YRC Public Data Repository - Protein Structure Prediction

Protein:	Pcmt-PA
Organism:	Drosophila melanogaster
Length:	226 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pcmt-PA.

Description	E-value	Query Range	Subject Range
gi\|115974015, gi... - gi\|115974015\|ref\|XP_001189051.1\| PREDICTED: similar to L-isoaspartyl protein carboxyl methyltransfer...	172.0	[0..1]	[222..1]
gi\|55243351, gi\|... - gi\|58380578\|ref\|XP_310636.2\| AGAP000457-PA [Anopheles gambiae str. PEST], gi\|55243351\|gb\|EAA06564.2\|... AGAP000457-PB, A... - protein-L-isoaspartate(D-aspartate) O-methyltransferase\|protein_coding\|X:7931088:7934574:-1\|gene:AGA...	171.0	[0..1]	[225..1]
gi\|108883206, gi... - gi\|157140935\|ref\|XP_001647679.1\| protein-l-isoaspartate o-methyltransferase [Aedes aegypti], gi\|1571...	169.0	[0..1]	[226..1]
PIMT_DANRE - Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Danio rerio GN=pcmt PE=2 SV=3	166.0	[0..1]	[223..1]
gi\|118601830, gi... - gi\|81673601\|gb\|AAI09664.1\| Protein-L-isoaspartate (D-aspartate) O-methyltransferase [Bos taurus], gi...	166.0	[0..1]	[225..1]
gi\|19070126 - gi\|19070126\|gb\|AAL83718.1\|AF239700_1 protein carboxyl-o-methyltransferase [Sus scrofa domestica] PIMT_PIG - Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Sus scrofa GN=PCMT1 PE=1 SV=3	166.0	[0..1]	[225..1]
PCMT1 - protein-L-isoaspartate (D-aspartate) O-methyltransferase ENSPTRT00000034524 - null	166.0	[0..1]	[225..1]
gi\|54639095\|gb\|E... - GA15271-PA [Drosophila pseudoobscura], GA15271 [Drosophila pseudoobscura pseudoobscura] gi\|54639095, gi\|... - gi\|54639095\|gb\|EAL28497.1\| GA15271 [Drosophila pseudoobscura pseudoobscura], gi\|125776671\|ref\|XP_001...	166.0	[0..1]	[226..1]
PIMT_MOUSE - Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Mus musculus GN=Pcmt1 PE=1 SV=3	166.0	[0..1]	[225..1]

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Predicted Domain #1

Region A:
Residues: [1-226]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWRSVGANN EDLIRQLKDH GVIASDAVAQ AMKETDRKHY SPRNPYMDAP QPIGGGVTIS  60
   61 APHMHAFALE YLRDHLKPGA RILDVGSGSG YLTACFYRYI KAKGVDADTR IVGIEHQAEL 120
  121 VRRSKANLNT DDRSMLDSGQ LLIVEGDGRK GYPPNAPYNA IHVGAAAPDT PTELINQLAS 180
  181 GGRLIVPVGP DGGSQYMQQY DKDANGKVEM TRLMGVMYVP LTDLRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.045757
Match:	1r18A
Description:	Drosophila protein isoaspartyl methyltransferase with S-adenosyl-L-homocysteine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein methyltransferase activity	5.03267617653315	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	4.4632173842967	bayes_pls_golite062009
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
histone methyltransferase activity	3.97658336148086	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	3.26663548517117	bayes_pls_golite062009
arginine N-methyltransferase activity	3.26663548517117	bayes_pls_golite062009
transferase activity	2.926540904444	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.86617323549909	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	2.48017990451667	bayes_pls_golite062009
O-methyltransferase activity	2.46301422147246	bayes_pls_golite062009
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	2.27866575945018	bayes_pls_golite062009
DNA-methyltransferase activity	2.18991764495147	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.91133457052099	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	1.69391860928068	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	1.15089820497406	bayes_pls_golite062009
DNA binding	1.11249468705987	bayes_pls_golite062009
transcription regulator activity	1.08316818833182	bayes_pls_golite062009
binding	0.976078016260105	bayes_pls_golite062009
nucleic acid binding	0.908932475461063	bayes_pls_golite062009
RNA methyltransferase activity	0.817509452491588	bayes_pls_golite062009
thiopurine S-methyltransferase activity	0.74333485845978	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	0.469870476227704	bayes_pls_golite062009
rRNA methyltransferase activity	0.230719796976667	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: