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Protein Overview: cno-PC

General Information:
Name(s) found: cno-PC / FBpp0288987 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene canoe is referred to in FlyBase by the symbol Dmel\cno (CG42312, FBgn0259212). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:998392..1043147. It has the cytological map location 82F4-82F6. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: dorsal closure; regulation of JNK cascade; compound eye development; ommatidial rotation. 49 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; rhabdomere; primary pigment cell; cell projection; cell part; stage 14 embryo; dorsal closure embryo. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1882 amino acids

    Gene Ontology:
    Cellular Component: adherens junction [IDA][NAS][TAS]
    cell cortex [IDA]
    zonula adherens [TAS]
    Biological Process: dorsal closure [IMP][TAS]
    Notch signaling pathway [TAS]
    ommatidial rotation [IMP]
    dorsal closure, elongation of leading edge cells [NAS]
    establishment or maintenance of cell polarity [NAS]
    JNK cascade [NAS]
    Ras protein signal transduction [TAS]
    compound eye development [IGI]
    regulation of JNK cascade [IGI][IMP][NAS]
    Molecular Function: actin binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHDKKMLDR EAVRSVIQQW NANRLDLFAL SEPDENLLFH GVMRFYFQDA GQKVATKCIR  60
   61 VASDATVTDV IDTLIEKFRP DMRMLSVPNY ALYEVHANGE ERRLNADEKP LLVQLNWHID 120
  121 DREGRFLLKN IDQKTTPIEQ TDLNFKRKLS KREKKEQKKK EKMAKLSSDP PTSNGSHLGL 180
  181 GNGVGASSGS AHMNGNAGGT GGDSSDAVAG KLYTELPETS FTRSISNPEA VMRRRRQQKL 240
  241 EKKLQQFRSR DGGPDTGGTL KIYGESLCQD VPYKTLLLSI RDCAQAVVRE MLTKYGLEKA 300
  301 DPLHYCLVQV NSDGTEYILD DDECPLSILM NHPTSRGSIM FHVRRRPADS QPRRRKKKPL 360
  361 GAANGANHIS GDREGPVLVE VTHSGDGGRR IKLGSDPVEV GSANTNCLQL FGPSIQPRHC 420
  421 LISLLEGVCT VTPLHTDALT FVNGHHISQP TILHNGSVVM FGRVASYRFL DSPTDGRYNL 480
  481 ALSQSQLDSA CLYERYRAST HYRPELQPTE RAHKLTMFLH HVANLVYSVV QEQYTDPRIL 540
  541 AFWMANSSEF LHFLKSDRHI SAFSVQAQEV LAEAVQTAFR NLVNCFRLEL SQTLNQFLSE 600
  601 NIDHDSAAGL VLTVLGSAMA LLRRCRVNAA LTIQLFSQLF HYINVICFNT IVANSQMCTG 660
  661 DWGKVMTERL QLLELWAERQ GLELAADCHL AKINQCAQFL QAPKSSVEEI QQLACSCFRL 720
  721 NSLQMAALLQ QEKLPRNLVD TAIRMAESVA DELTRADGRE VRLEESPELH LALLLPDDGF 780
  781 SCDVVRGIPT GLVDFLNPLQ QQGMCRLAAQ PTSIGLWTVY MHQFNARSSS AMSNKLPQPE 840
  841 LQLIKLHKNS NGMGLSIVAA KGAGQEKLGI YIKSVVPGGA ADADGRLQAG DQLLRVDGQS 900
  901 LIGITQERAA DYLVRTGPVV SLEVAKQGAI YHGLATLLQQ PSPVIQRGNR RMSERDLTRM 960
  961 GGAESTKSLG PLIANNHPNH SLSLSQHLNN SHNNTLGNSN NSSIINPLAA HLPNSKSVPA1020
 1021 LHHHTGSGTI SLANSKSRST HSLHNNTSGM GGIGGAAAGG MLGQPNGSQN NANGNGNGNE1080
 1081 QGFYQNLSVY RAQNQSQPIL NERPPIAAHA AMNAYNGSSP LAPQQQPQQQ QQSPYQQQQQ1140
 1141 QQHMQANANL PPTRPVSAYY HSQQSAQQQL QQQQQQQQQH SLQQQQFALS SGNLNGQQQQ1200
 1201 QQQHQHQHQL TLNNRTKSQQ NFQHTLRMQQ MMAPSMPNIS NMYHHQQQQQ QQLPLQQQQQ1260
 1261 QQQQPLMSSS QSMQNVNDFA GGYQNGSLEY RRSQLHDPST LYEIQQQQLQ QQQQQQQQQQ1320
 1321 QQQQASPNFI ALPPKPLGSL QSPNKPNVPP STAPKPQQDK PPLPPTATHP LFKATQQIAP1380
 1381 GMNYVASTLD PPKGSYVASN QGNNRPLHSG SNPWEREERE KDLEMRREHI RQWREQQISE1440
 1441 LSQIVSRSPM QEEQLKTLIL ERDFERRAQE LQEQEEQDQE QQYDKENVQE LFRLAGGGQV1500
 1501 SAIQTPITSY RQTEIKLAEM PDSNSLVDSV PPQPPAPTAQ PLSSNTQQPK SILKHNRYSE1560
 1561 GGVGPSGAPS SPSKSQKSAS FADERHLHTE HPISNLAKEL NQLTMLDKDN NNETLDAVVP1620
 1621 PPPPPERNSS YLIMSQQKLR GSTGNATSSM GLLKTATSNQ AAAAVEIKKA SLLNTQTNNN1680
 1681 NNLSGSLNNN TMHGSPLSAM ELNAAYVSAT GTGIIGGLGT PPPPPPLMQR DNKRVSFHDE1740
 1741 ENNFVSGNSQ QQQLQQQYIM DNYGMEHQDL DTIREDTSYL QHNLDASMLP SMPATPDAAL1800
 1801 WNTSVQSTPG VIGAQEVYRD PRTRRLAEKQ QQQQQQRAGD AVPEKLSFKE KMKMFALESG1860
 1861 EDKTPKDKLK ISRAQRDIDA VH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] FFAS03 2.4 Solution Structure of Ras-binding Domain in Mouse AF-6 Protein
    2 View Details [169..254] deduced N/A No confident structure predictions are available.
    3 View Details [255..370] PSI-BLAST 30.045757 Solution Structure of Ras-binding Domain in Mouse AF-6 Protein
    4 View Details [371..455] PSI-BLAST 31.39794 Solution structure of the FHA domain of mouse Afadin 6
    5 View Details [456..806] PSI-BLAST 44.0 Myosin V cargo binding domain
    6 View Details [807..915] PSI-BLAST 19.69897 Structure of AF-6 PDZ domain
    7 View Details [916..1882] PSI-BLAST 10.522879 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.0155013961187369 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  0.0934358341245259 bayes_pls_golite062009
  • protein binding
    		•  0.03789551947602 bayes_pls_golite062009
    4
    Term Confidence Notes
  • binding
    		•  0.962970280214435 bayes_pls_golite062009
  • protein binding
    		•  0.56456434217804 bayes_pls_golite062009
    5 No functions predicted.
    6
    Term Confidence Notes
  • binding
    		•  0.566291652083235 bayes_pls_golite062009
  • protein binding
    		•  0.52823753548825 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle