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Protein Overview: cno-PE

General Information:
Name(s) found: cno-PE / FBpp0289752 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene canoe is referred to in FlyBase by the symbol Dmel\cno (CG42312, FBgn0259212). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:998392..1043147. It has the cytological map location 82F4-82F6. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: dorsal closure; regulation of JNK cascade; compound eye development; ommatidial rotation. 49 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; rhabdomere; primary pigment cell; cell projection; cell part; stage 14 embryo; dorsal closure embryo. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2051 amino acids

    Gene Ontology:
    Cellular Component: adherens junction [IDA][NAS][TAS]
    cell cortex [IDA]
    zonula adherens [TAS]
    Biological Process: dorsal closure [IMP][TAS]
    Notch signaling pathway [TAS]
    ommatidial rotation [IMP]
    dorsal closure, elongation of leading edge cells [NAS]
    establishment or maintenance of cell polarity [NAS]
    JNK cascade [NAS]
    Ras protein signal transduction [TAS]
    compound eye development [IGI]
    regulation of JNK cascade [IGI][IMP][NAS]
    Molecular Function: actin binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHDKKMLDR EAVRSVIQQW NANRLDLFAL SEPDENLLFH GVMRFYFQDA GQKVATKCIR  60
   61 VASDATVTDV IDTLIEKFRP DMRMLSVPNY ALYEVHANGE ERRLNADEKP LLVQLNWHID 120
  121 DREGRFLLKN IDQKTTPIEQ TDLNFKRKLS KREKKEQKKK EKMAKLSSDP PTSNGSHLGL 180
  181 GNGVGASSGS AHMNGNAGGT GGDSSDAVAG KLYTELPETS FTRSISNPEA VMRRRRQQKL 240
  241 EKKLQQFRSR DGGPDTGGTL KIYGESLCQD VPYKTLLLSI RDCAQAVVRE MLTKYGLEKA 300
  301 DPLHYCLVQV NSDGTEYILD DDECPLSILM NHPTSRGSIM FHVRRRPADS QPRRRKKKPL 360
  361 GAANGANHIS GDREGPVLVE VTHSGDGGRR IKLGSDPVEV GSANTNCLQL FGPSIQPRHC 420
  421 LISLLEGVCT VTPLHTDALT FVNGHHISQP TILHNGSVVM FGRVASYRFL DSPTDGRYNL 480
  481 ALSQSQLDSA CLYESRSPTS PGSWNDEDGA LSSTHKSDYD HHQQANHSSA YHNNNNNSSD 540
  541 HPLSSTLRDV VDSKAGQDQG ANSGNYDGQS LEGNLENETK SISSLKSGGS NSQDRSPKMT 600
  601 GSGILAGGGS GSGDTQGQEP ILPAVLEFPE THQELFLRHI ISELDVNVPH FKLAPVYSLY 660
  661 LCARYRASTH YRPELQPTER AHKLTMFLHH VANLVYSVVQ EQYTDPRILA FWMANSSEFL 720
  721 HFLKSDRHIS AFSVQAQEVL AEAVQTAFRN LVNCFRLELS QTLNQFLSEN IDHDSAAGLV 780
  781 LTVLGSAMAL LRRCRVNAAL TIQLFSQLFH YINVICFNTI VANSQMCTGD WGKVMTERLQ 840
  841 LLELWAERQG LELAADCHLA KINQCAQFLQ APKSSVEEIQ QLACSCFRLN SLQMAALLQQ 900
  901 EKLPRNLVDT AIRMAESVAD ELTRADGREV RLEESPELHL ALLLPDDGFS CDVVRGIPTG 960
  961 LVDFLNPLQQ QGMCRLAAQP TSIGLWTVYM HQFNARSSSA MSNKLPQPEL QLIKLHKNSN1020
 1021 GMGLSIVAAK GAGQEKLGIY IKSVVPGGAA DADGRLQAGD QLLRVDGQSL IGITQERAAD1080
 1081 YLVRTGPVVS LEVAKQGAIY HGLATLLQQP SPVIQRGNRR MSERDLTRMG GAESTKSLGP1140
 1141 LIANNHPNHS LSLSQHLNNS HNNTLGNSNN SSIINPLAAH LPNSKSVPAL HHHTGSGTIS1200
 1201 LANSKSRSTH SLHNNTSGMG GIGGAAAGGM LGQPNGSQNN ANGNGNGNEQ GFYQNLSVYR1260
 1261 AQNQSQPILN ERPPIAAHAA MNAYNGSSPL APQQQPQQQQ QSPYQQQQQQ QHMQANANLP1320
 1321 PTRPVSAYYH SQQSAQQQLQ QQQQQQQQHS LQQQQFALSS GNLNGQQQQQ QQHQHQHQLT1380
 1381 LNNRTKSQQN FQHTLRMQQM MAPSMPNISN MYHHQQQQQQ QLPLQQQQQQ QQQPLMSSSQ1440
 1441 SMQNVNDFAG GYQNGSLEYR RSQLHDPSTL YEIQQQQLQQ QQQQQQQQQQ QQQASPNFIA1500
 1501 LPPKPLGSLQ SPNKPNVPPS TAPKPQQDKP PLPPTATHPL FKATQQIAPG MNYVASTLDP1560
 1561 PKGSYVASNQ GNNRPLHSGS NPWEREEREK DLEMRREHIR QWREQQISEL SQIVSRSPMQ1620
 1621 EEQLKTLILE RDFERRAQEL QEQEEQDQEQ QYDKENVQEL FRLAGGGQVS AIQTPITSYR1680
 1681 QTEIKLAEMP DSNSLVDSVP PQPPAPTAQP LSSNTQQPKS ILKHNRYSEG GVGPSGAPSS1740
 1741 PSKSQKSASF ADERHLHTEH PISNLAKELN QLTMLDKDNN NETLDAVVPP PPPPERNSSY1800
 1801 LIMSQQKLRG STGNATSSMG LLKTATSNQA AAAVEIKKAS LLNTQTNNNN NLSGSLNNNT1860
 1861 MHGSPLSAME LNAAYVSATG TGIIGGLGTP PPPPPLMQRD NKRVSFHDEE NNFVSGNSQQ1920
 1921 QQLQQQYIMD NYGMEHQDLD TIREDTSYLQ HNLDASMLPS MPATPDAALW NTSVQSTPGV1980
 1981 IGAQEVYRDP RTRRLAEKQQ QQQQQRAGDA VPEKLSFKEK MKMFALESGE DKTPKDKLKI2040
 2041 SRAQRDIDAV H

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..244] PSI-BLAST 40.0 No description for 2dfsA was found.
    2 View Details [245..345] PSI-BLAST 25.69897 Solution Structure of Ras-binding Domain in Mouse AF-6 Protein
    3 View Details [346..537] PSI-BLAST 24.39794 Solution structure of the FHA domain of mouse Afadin 6
    4 View Details [538..595] deduced N/A No confident structure predictions are available.
    5 View Details [596..977] PSI-BLAST 48.30103 Myosin V cargo binding domain
    6 View Details [978..1112] PSI-BLAST 17.0 Structure of AF-6 PDZ domain
    7 View Details [1113..2051] PSI-BLAST 13.154902 No description for 1y0fB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  0.0934358341245259 bayes_pls_golite062009
  • protein binding
    		•  0.03789551947602 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  0.962970280214435 bayes_pls_golite062009
  • protein binding
    		•  0.56456434217804 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • binding
    		•  0.566291652083235 bayes_pls_golite062009
  • protein binding
    		•  0.52823753548825 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle