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View Structure Prediction Details

Protein: cno-PE
Organism: Drosophila melanogaster
Length: 2051 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cno-PE.

Description E-value Query
Range
Subject
Range
gi|16184229 - gi|16184229|gb|AAL13776.1| LD24616p [Drosophila melanogaster]
1461.0 [0..1] [2051..1]

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Predicted Domain #1
Region A:
Residues: [1-244]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHDKKMLDR EAVRSVIQQW NANRLDLFAL SEPDENLLFH GVMRFYFQDA GQKVATKCIR  60
   61 VASDATVTDV IDTLIEKFRP DMRMLSVPNY ALYEVHANGE ERRLNADEKP LLVQLNWHID 120
  121 DREGRFLLKN IDQKTTPIEQ TDLNFKRKLS KREKKEQKKK EKMAKLSSDP PTSNGSHLGL 180
  181 GNGVGASSGS AHMNGNAGGT GGDSSDAVAG KLYTELPETS FTRSISNPEA VMRRRRQQKL 240
  241 EKKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.0
Match: 2dfsA
Description: No description for 2dfsA was found.

Predicted Domain #2
Region A:
Residues: [245-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQFRSRDGGP DTGGTLKIYG ESLCQDVPYK TLLLSIRDCA QAVVREMLTK YGLEKADPLH  60
   61 YCLVQVNSDG TEYILDDDEC PLSILMNHPT SRGSIMFHVR R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1wxaA
Description: Solution Structure of Ras-binding Domain in Mouse AF-6 Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.0934358341245259 bayes_pls_golite062009
protein binding 0.03789551947602 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [346-537]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPADSQPRRR KKKPLGAANG ANHISGDREG PVLVEVTHSG DGGRRIKLGS DPVEVGSANT  60
   61 NCLQLFGPSI QPRHCLISLL EGVCTVTPLH TDALTFVNGH HISQPTILHN GSVVMFGRVA 120
  121 SYRFLDSPTD GRYNLALSQS QLDSACLYES RSPTSPGSWN DEDGALSSTH KSDYDHHQQA 180
  181 NHSSAYHNNN NN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.39794
Match: 1wlnA
Description: Solution structure of the FHA domain of mouse Afadin 6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.962970280214435 bayes_pls_golite062009
protein binding 0.56456434217804 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [538-595]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSDHPLSSTL RDVVDSKAGQ DQGANSGNYD GQSLEGNLEN ETKSISSLKS GGSNSQDR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [596-977]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPKMTGSGIL AGGGSGSGDT QGQEPILPAV LEFPETHQEL FLRHIISELD VNVPHFKLAP  60
   61 VYSLYLCARY RASTHYRPEL QPTERAHKLT MFLHHVANLV YSVVQEQYTD PRILAFWMAN 120
  121 SSEFLHFLKS DRHISAFSVQ AQEVLAEAVQ TAFRNLVNCF RLELSQTLNQ FLSENIDHDS 180
  181 AAGLVLTVLG SAMALLRRCR VNAALTIQLF SQLFHYINVI CFNTIVANSQ MCTGDWGKVM 240
  241 TERLQLLELW AERQGLELAA DCHLAKINQC AQFLQAPKSS VEEIQQLACS CFRLNSLQMA 300
  301 ALLQQEKLPR NLVDTAIRMA ESVADELTRA DGREVRLEES PELHLALLLP DDGFSCDVVR 360
  361 GIPTGLVDFL NPLQQQGMCR LA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.30103
Match: 2f6hX
Description: Myosin V cargo binding domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [978-1112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQPTSIGLWT VYMHQFNARS SSAMSNKLPQ PELQLIKLHK NSNGMGLSIV AAKGAGQEKL  60
   61 GIYIKSVVPG GAADADGRLQ AGDQLLRVDG QSLIGITQER AADYLVRTGP VVSLEVAKQG 120
  121 AIYHGLATLL QQPSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 1xz9A
Description: Structure of AF-6 PDZ domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.566291652083235 bayes_pls_golite062009
protein binding 0.52823753548825 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1113-2051]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIQRGNRRMS ERDLTRMGGA ESTKSLGPLI ANNHPNHSLS LSQHLNNSHN NTLGNSNNSS  60
   61 IINPLAAHLP NSKSVPALHH HTGSGTISLA NSKSRSTHSL HNNTSGMGGI GGAAAGGMLG 120
  121 QPNGSQNNAN GNGNGNEQGF YQNLSVYRAQ NQSQPILNER PPIAAHAAMN AYNGSSPLAP 180
  181 QQQPQQQQQS PYQQQQQQQH MQANANLPPT RPVSAYYHSQ QSAQQQLQQQ QQQQQQHSLQ 240
  241 QQQFALSSGN LNGQQQQQQQ HQHQHQLTLN NRTKSQQNFQ HTLRMQQMMA PSMPNISNMY 300
  301 HHQQQQQQQL PLQQQQQQQQ QPLMSSSQSM QNVNDFAGGY QNGSLEYRRS QLHDPSTLYE 360
  361 IQQQQLQQQQ QQQQQQQQQQ QASPNFIALP PKPLGSLQSP NKPNVPPSTA PKPQQDKPPL 420
  421 PPTATHPLFK ATQQIAPGMN YVASTLDPPK GSYVASNQGN NRPLHSGSNP WEREEREKDL 480
  481 EMRREHIRQW REQQISELSQ IVSRSPMQEE QLKTLILERD FERRAQELQE QEEQDQEQQY 540
  541 DKENVQELFR LAGGGQVSAI QTPITSYRQT EIKLAEMPDS NSLVDSVPPQ PPAPTAQPLS 600
  601 SNTQQPKSIL KHNRYSEGGV GPSGAPSSPS KSQKSASFAD ERHLHTEHPI SNLAKELNQL 660
  661 TMLDKDNNNE TLDAVVPPPP PPERNSSYLI MSQQKLRGST GNATSSMGLL KTATSNQAAA 720
  721 AVEIKKASLL NTQTNNNNNL SGSLNNNTMH GSPLSAMELN AAYVSATGTG IIGGLGTPPP 780
  781 PPPLMQRDNK RVSFHDEENN FVSGNSQQQQ LQQQYIMDNY GMEHQDLDTI REDTSYLQHN 840
  841 LDASMLPSMP ATPDAALWNT SVQSTPGVIG AQEVYRDPRT RRLAEKQQQQ QQQRAGDAVP 900
  901 EKLSFKEKMK MFALESGEDK TPKDKLKISR AQRDIDAVH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.154902
Match: 1y0fB
Description: No description for 1y0fB was found.

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