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Protein Overview: gig-PA

General Information:
Name(s) found: gig-PA / FBpp0074588 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene gigas is referred to in FlyBase by the symbol Dmel\gig (CG6975, FBgn0005198). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:20122282..20132450. It has the cytological map location 76F2. There is experimental evidence that it has the molecular function</span>: protein binding; kinase binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: regulation of biological process; regulation of anatomical structure size; transport; response to DNA damage stimulus; response to nutrient levels; regulation of response to stimulus; reproductive process in a multicellular organism; determination of adult lifespan; primary metabolic process; negative regulation of growth; negative regulation of cell size. 47 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; organ system; compound cell cluster organ; adult segment; adult mesothoracic segment; rhabdomere; cell cycle; neuron; cell projection. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1847 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: signal transduction [IGI]
    negative regulation of cell proliferation [IGI][IMP]
    determination of adult lifespan [IMP]
    response to nutrient [IMP]
    negative regulation of organ growth [IGI]
    response to DNA damage stimulus [IMP]
    negative regulation of insulin receptor signaling pathway [IGI]
    positive regulation of GTPase activity [IEA]
    phagocytosis, engulfment [IMP]
    oogenesis [IMP]
    negative regulation of cell growth [IGI][IMP]
    regulation of small GTPase mediated signal transduction [IEA]
    negative regulation of cell size [IGI]
    lipid metabolic process [IGI]
    regulation of cell cycle [IMP]
    Molecular Function: protein binding [IPI]
    GTPase activator activity [IEA]
    kinase binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSKDKSKFK LFLKSLPAGY VGERTLRPEF ERELRPEQPV AQRCRMLKEL GDTQLHNFNL  60
   61 DESAITILFN LTNDLIVPNK PAETRQIALS FYKRLIHTQY KNLTIMREKF FLVIQNHEAR 120
  121 EDLRHLLELL DTLTDNGKDI TNFEEKIGKF MLLWIPAITE ANLLTPYLDI LVNLIKFNAA 180
  181 HLDKDILVGI VQNACDLSCS VTVNEIGLQC LTILEMVIGY TIFPSEPLPQ CITTLCRTVN 240
  241 HAPYCPSSFK IMKNLLGTQL GYHSMKMMCS ILNDRALYDD AHLLRGAVFH LNMNIFGSNI 300
  301 IFQVSPMTYA TNVLTAFLRA LDSRQVIVTF EVILSVRMVI TKRQLSEIIW DLICDIMSSI 360
  361 VSNIEYYEEV NINKDRLHHL QINFHENIDC IEKLLQQDRS QILGNVERIY DLIERVADRR 420
  421 PEASVLALIE YRSRRVTATR PDWLQVLAQF VRRYYRMSNV NVRIKTIEAL VQIMDQNRAC 480
  481 YEEEILSRVV LVHLSHIHLE SSVQVRVAVA RALSNFATHC DTKRCMDLLD ILEALINRPF 540
  541 EHTRHGSSSG EGTLAEVTFG LVNNESEISD IIAAVDGLVK VFAIKLHRLP GIHALKIFNI 600
  601 LMDHLELHYE RPKIFEHISV VRYKIFAWLL KARANGSYHI GYPEGSTEVV KFSPYLGIDS 660
  661 PLLPQAHPTA ISIRRVCKLI VRCLEHDTDY QVFQLVIREL PKVLQNKALV QGNDIEELAN 720
  721 TLLKINLVSN NKFKRPTDEF HALVLPAIAS LVIYHESLQP QQHYGIITAL NSRVLTGIAS 780
  781 VCINTMTILI LEMPEALMRK LPDVLLQMSK MSDTNALATP VLEFLSLLIH LSKHLFANFT 840
  841 SMHNMYVFAI TLPYTKPHRY DHYTVSLAHH VIAGWFLKCK LELRRNCVNY IKSSIQSNAK 900
  901 MLSSDIVNLN SLNEDSSNRK RSTSLTERGS RNNANAWNDL EMRPQMNNGL RNFHAELAET 960
  961 CFDFLARHTY SPCPSMPKRL PAAEFLLKDG VSQTWLVGNN LVTITTSGCP SAPARSGLCE1020
 1021 RCAQLGKAPS ISLNSKSLSD AAPPLSPERE RRYTKVSLQH SSGNESAGST ELTSSSSSNS1080
 1081 AAAGGHPHRQ ISNSSTASLD ALSRRGSNPE ALGSALGEGA HTGSNTSLLG NSLSQSSVSM1140
 1141 SPSSGSVVQQ PVCVRACTGW AEVLVRRPTG NVSWITRIQN PITNDCFGQE LPFNNVVSLF1200
 1201 LPTAHGGVFG PDNTIQAPPH TLADPEPEPE AEVNAATAPQ ASALRSRMVA KARALQRQEE1260
 1261 IHSVGGNGNG NGNGNGSGNA PSTGGAAAIP IPRVPASGKR GKEAALCGSV SDGEADDDSL1320
 1321 AFEDAQSRAR NPVRRVNSSP EMSSSWRQSF LTNKPTPLSQ EPVKTTADEP QSLLTLKKKT1380
 1381 VQYSTKDMRV SCEAIPEEIA GSTPPSQAAA LALQPESGTL PPKQHSADDV SSHVAGGSNL1440
 1441 QAGGSTLKLG KPPLSPGQPP LLGTGRVTSF GGTSVPQPGA LAKSSSSGSN GTNVGVITSD1500
 1501 YDNGNNGNGD MMRGRSKTIS VVREVNNGNT RPPPASSFRN FGAAKPPINT KLCMNPSFIF1560
 1561 MQLYTTGQLG VTDEPLKVGP ENSSAVSLID LVPPFETHKI GVLYVGQGQC NNEVEILRNS1620
 1621 HGSARYVEFL RNIGTLVSLK EAEQNNLFIM LDRNGADGKF AYIWKDDILQ VTFHVATLMP1680
 1681 TNLQDDPNCN EKKSHIGNDF VKIIYNESGE EYNLNTISGQ FNYACVIVEP LDLNSNRVYV1740
 1741 KARSEISKFV CHAEYRIVSD RSAPLLARQM ALHANLASLV YQSVQKKHPY ASNWLERLRK1800
 1801 LKRLRSKLIE GLNSQQKSGS ASSGIGINAS AIGSDMDDQR GDFIKYT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle