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Protein Overview: Pros26-PA

General Information:
Name(s) found: Pros26-PA / FBpp0075119 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Proteasome 26kD subunit is referred to in FlyBase by the symbol Dmel\Pros26 (CG4097, FBgn0002284). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:16602497..16603521. It has the cytological map location 73B1. Based on sequence similarity, it is predicted to have molecular function</span>: endopeptidase activity. It is reported to be involved in the biological process</span>: ubiquitin-dependent protein catabolic process; ATP-dependent proteolysis. 14 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: adult segment; organ system; adult; peripheral nervous system; nervous system; external compound sense organ; imaginal precursor; abdominal sternite 5; region of integument; abdominal segment 7. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 235 amino acids

    Gene Ontology:
    Cellular Component: proteasome core complex [ISS][NAS]
    proteasome complex [NAS]
    Biological Process: proteolysis involved in cellular protein catabolic process [IEA]
    ubiquitin-dependent protein catabolic process [NAS]
    Molecular Function: endopeptidase activity [ISS][NAS]
    threonine-type endopeptidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRLGFEQFP DYQVPGMKHP DFSPYESNGG SIVAIAGDDF AVIAADTRLS SGYNIHSRTQ  60
   61 SKLFKLSPQT VLGSAGCWAD TLSLTGSIKV RMQSYEHTHL RTMTTEAVAQ MLSIAMYNRR 120
  121 FFPYYVSNIL AGIDNEGKGV VYSYDPIGHC EKATYRAGGT AGTLLQPVLD NQIGHKNMNL 180
  181 EDADKIKLTK ERAVSVASDT FISAAERDIY TGDSVLINII TKDGIEVRTL TLRQD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] PSI-BLAST 44.221849 Proteasome beta subunit (catalytic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • binding
    		•  1.18139971903068 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.448212653390607 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle