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Protein Overview: TfIIEbeta-PA

General Information:
Name(s) found: TfIIEbeta-PA / FBpp0073090 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Transcription factor IIEÃ?&#142;Ã?² is referred to in FlyBase by the symbol Dmel\TfIIEÃ?&#142;Ã?² (CG1276, FBgn0015829). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:4287038..4288349. It has the cytological map location 64A12. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 292 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIE complex [ISS]
    Biological Process: transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: general RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPALLRERE AFKKRAMATP TVEKKSKPDR PAPPPPSDDS RRKMRPPNAP RLDATTYKTM  60
   61 SGSSQYRFGV LAKIVKFMRT RHQDGDDHPL TIDEILDETN QLDIGQSVKN WLASEALHNN 120
  121 PKVEASPCGT KFSFKPVYKI KDGKTLMRLL KQHDLKGLGG ILLDDVQESL PHCEKVLKNR 180
  181 SAEILFVVRP IDKKKILFYN DRTANFSVDD EFQKLWRSAT VDAMDDAKID EYLEKQGIRS 240
  241 MQDHGLKKAI PKRKKAANKK RQFKKPRDNE HLADVLEVYE DNTLTLKGVN PT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] PSI-BLAST 28.69897 The central core domain of TFIIE beta
    2 View Details [154..292] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.67074370996647 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  4.84466441605416 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.57954522145536 bayes_pls_golite062009
  • transcription factor activity
    		•  4.12685284895733 bayes_pls_golite062009
  • binding
    		•  3.33026160538031 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.3918869755162 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.82365519759474 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.82365519759474 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.81270943531115 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • protein binding
    		•  0.653872239015235 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.237727660028553 bayes_pls_golite062009
  • positive transcription elongation factor activity
    		•  0.13524243942225 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.0360186926687502 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle