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Protein Overview: alpha-Spec-PA

General Information:
Name(s) found: alpha-Spec-PA / FBpp0072672 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Ã?&#142;Ã?± Spectrin is referred to in FlyBase by the symbol Dmel\Ã?&#142;Ã?±-Spec (CG1977, FBgn0250789). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:1779111..1795319. It has the cytological map location 62B4. There is experimental evidence that it has the molecular function</span>: actin binding; microtubule binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of microtubule depolymerization; central nervous system development; neuromuscular synaptic transmission; regulation of synapse organization; germarium-derived oocyte fate determination; long-term strengthening of neuromuscular junction; oocyte construction; maintenance of presynaptic active zone structure; germarium-derived female germ-line cyst formation; axon midline choice point recognition. 43 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: organ system; embryonic nervous system; anatomical structure; nervous system; cytoplasmic part; multi-cell-component structure; neuron; embryonic glial cell; synapse; postsynaptic membrane; commissure. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2415 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    cytoskeleton [ISS]
    cell cortex [IDA]
    Golgi apparatus [IDA]
    neuromuscular junction [IDA]
    fusome [IDA]
    spectrosome [IDA][TAS]
    spectrin [ISS][NAS]
    plasma membrane [IDA]
    Biological Process: regulation of cell shape [NAS]
    cell-cell adhesion [NAS]
    neuromuscular synaptic transmission [IMP]
    cytoskeleton organization [ISS]
    regulation of synapse organization [IMP]
    germarium-derived oocyte fate determination [IMP][TAS]
    [NOT]female germline ring canal formation, actin assembly [TAS]
    fusome organization [TAS]
    negative regulation of microtubule depolymerization [IMP]
    instar larval development [NAS]
    oocyte construction [IMP]
    plasma membrane organization [TAS]
    central nervous system development [IMP]
    maintenance of presynaptic active zone structure [IDA]
    germarium-derived female germ-line cyst formation [IMP]
    long-term strengthening of neuromuscular junction [IMP]
    ovarian follicle cell development [TAS]
    germ-line cyst formation [TAS]
    axon midline choice point recognition [IGI]
    spectrosome organization [TAS]
    Molecular Function: calmodulin binding [NAS]
    actin binding [IDA][ISS][NAS]
    calcium ion binding [ISS]
    cytoskeletal protein binding [ISS]
    microtubule binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENFTPKEVK ILETVEDIQE RREQVLSRYN DFKIETRQKR EKLEDSRRFQ YFKRDADELE  60
   61 SWIHEKLQAA SEESYRDPTN LQAKIQKHQA FEAEVSAHSN AIVSLDNTGQ EMINQQHFAS 120
  121 ESIQVRLDEL HKLWELLLSR LAEKGLKLQQ ALVLVQFLRQ CEEVMFWIKD KETFVTADEF 180
  181 GQDLEHVEVL QRKFDEFQKD MASQEYRVTE VNQLADKLVQ DGHPERDTIT KRKEELNEAW 240
  241 QRLKQLAIVR QEKLFGAHEI QRFNRDADET VAWIAEKDVV LSSDDYGRDL ASVQALQRKH 300
  301 EGVERDLAAL EDKVSTLGAE AQRLCSIHAD HSDQIRDKQA EIANYWQSLT TKARERKQKL 360
  361 DESYYLHRFL ADFRDLVSWI NGMKAIISAD ELAKDVAGAE ALLERHQEHK GEIDAREDSF 420
  421 KLTTESGQKL LEREHYAAAE IQEKLAALEN DKSSLLSLWE DRRILYEQCM DLQLFYRDTE 480
  481 QADTWMAKQE AFLANEDLGD SLDSVEALIK KHEDFEKSLA AQEEKIKALD IFATKLIDGQ 540
  541 HYAADDVAQR RQMLLARRAA LQEKSSKRRQ LLEDSNRYQQ FERDCDETKG WISEKLKFAT 600
  601 DDSYLDPTNL NGKMQKHQNF EHELNANKSR IEDITNVGTE LIEKQHYAAD QINTRMQEIV 660
  661 VLWETLVQAS DKKGTKLNEA CQQQQFNRTI EDIELWLSEI EGQLLSEDHG KDLTSVQNLQ 720
  721 KKHALLEADV MAHQDRIESI KVAANKFIES GHFDADNIRN KEGNLSARYA ALAAPMGERK 780
  781 QHLLDSLQVQ QLFRDLEDEA AWIREKEPIA ASTNRGRDLI GVQNLIKKHQ AVLAEINNHE 840
  841 ARLLNVISSG ENMLKDQPFA SDDIRQRLEA LQEQWNTLKE KSSQRKQDLD DSLQAHQYFA 900
  901 DANEAESWMR EKEPIATGSD YGKDEDSSEA LLKKHEALVS DLEAFGNTIQ ALQEQAKNCR 960
  961 QQETPVVDIT GKECVVALYD YTEKSPREVS MKKGDVLTLL NSNNKDWWKV EVNDRQGFVP1020
 1021 AAYIKKIDAG LSASQQNLVD NHSIAKRQNQ INSQYDNLLA LARERQNKLN ETVKAYVLVR1080
 1081 EAADLAQWIR DKENHAQIAD VVGEDLEEVE VLQKKFDDFN DDLKANEVRL ANMNEIAVQL1140
 1141 TSLGQTEAAL KIQTQMQDLN EKWNNLQTLT AEKASQLGSA HEVQRFHRDI DETKDWIAEK1200
 1201 ANALNNDDLG KDLRSVQTLQ RKHEGVERDL AALRDKIRQL DETANRLMQS HPDTAEQTYA1260
 1261 KQKEINEMWD QIITKSTARK EKLLDSYDLQ RFLSDYRDLL AWINSMMSLV TSDELANDVT1320
 1321 GAEALIERHQ EHRTEIDARA GTFGAFEQFG NELLQANHYA SPEIKEKIED LAKAREDLEK1380
 1381 AWTERRLQLE QNLDLQLYMR DCELAESWMS AREAFLNADD DANAGGNVEA LIKKHEDFDK1440
 1441 AINGHEQKIA ALQTVADQLI AQNHYASNLV DEKRKQVLER WRHLKEGLIE KRSRLGDEQT1500
 1501 LQQFSRDADE IENWIAEKLQ LATEESYKDP ANIQSKHQKH QAFEAELAAN ADRIQSVLAM1560
 1561 GGNLIDKKQC SGSEDAVQKR LTQIADQWEY LTHKTTEKSL KLKEANKQRT YIAAVKDLDF1620
 1621 WLGEVESLLT TEDSGKDLAS VQNLMKKHQL VEADIVAHED RIKDMNNQAD SLVESGQFDT1680
 1681 AGIQEKRQSI NERYERICNL AAHRQARLNE ALTLHQFFRD IADEESWIKE KKLLVGSDDY1740
 1741 GRDLTGVQNL KKKHKRLEAE LGSHEPAIQA VQEAGEKLMD VSNLGVPEIE QRLKALNQAW1800
 1801 AELKNLAATR GQKLDESLTY QQFLAQVEEE EAWITEKQQL LSVEDYGDSM AAVQGLLKKH1860
 1861 DAFETDFTAH KDRCSLICDQ GSELVEAKNH HGESIAQRCQ QLRLKLDNLS ALAARRKGAL1920
 1921 LDNSAYLQFM WKADVVESWI DDKENYVRSD EFGRDLSTVQ TLLTKQETFD AGLNAFEQEG1980
 1981 IHNITALKDQ LINASHAQSP AILKRHGDVI ARWQKLRDAS NTRKDRLLAM QEQFRQIEEL2040
 2041 YLTFAKKASA FNSWFENAEE DLTDPVRCNS IEEIRALRDA HAQFQASLSS AEADFKALAA2100
 2101 LDQKIKSFNV GPNPYTWFTM EALEETWRNL QKIIEERDGE LAKEAKRQEE NDKLRKEFAK2160
 2161 HANLFHQWLT ETRTSMMEGS GSLEQQLEAL RVKATEVRAR RVDLKKIEEL GALLEEHLIL2220
 2221 DNRYTEHSTV GLAQQWDQLD QLSMRMQHNL EQQIQARNHS GVSEDSLKEF SMMFKHFDKD2280
 2281 KSGKLNHQEF KSCLRALGYD LPMVEEGQPD PEFEAILDVV DPNRDGYVSL QEYIAFMISK2340
 2341 ETENVQSYEE IENAFRAITA ADRPYVTKEE LYCNLTKDMA DYCVQRMKPF SEPRSGQPIK2400
 2401 DALDYIDFTR TLFQN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

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