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Protein Overview: gsb-PA

General Information:
Name(s) found: gsb-PA / FBpp0072349 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene gooseberry is referred to in FlyBase by the symbol Dmel\gsb (CG3388, FBgn0001148). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20949502..20952166. It has the cytological map location 60F2. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: salivary gland morphogenesis. 26 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: organ system; embryonic neuron; embryonic nervous system; primordium; U neuron; ventral nerve cord primordium; portion of tissue; cuticle; anatomical structure; embryonic head; adult; neuroblast NB4-2; external compound sense organ; commissure; antennal segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 427 amino acids

    Gene Ontology:
    Cellular Component: transcription factor complex [ISS]
    nucleus [IMP][NAS]
    cytoplasm [IMP]
    Biological Process: ventral cord development [TAS]
    segment polarity determination [NAS]
    regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IEA][ISS]
    salivary gland morphogenesis [IMP]
    Molecular Function: transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSALNMTP YFGGYPFQGQ GRVNQLGGVF INGRPLPNHI RRQIVEMAAA GVRPCVISRQ  60
   61 LRVSHGCVSK ILNRFQETGS IRPGVIGGSK PRVATPDIES RIEELKQSQP GIFSWEIRAK 120
  121 LIEAGVCDKQ NAPSVSSISR LLRGSSGSGT SHSIDGILGG GAGSVGSEDE SEDDAEPSVQ 180
  181 LKRKQRRSRT TFSNDQIDAL ERIFARTQYP DVYTREELAQ STGLTEARVQ VWFSNRRARL 240
  241 RKQLNTQQVP SFAPTSTSFG ATPTTSAAPA PNMGMSLYSS QSWPSSGAYE NHAAYGGSVA 300
  301 SMSPASSTSG TSSAAHSPVQ TQAQQPGTGS EFMTSTYGVG SSNATYPSAA YSMPQTPATS 360
  361 AEQLRSQFAS AAASGSHHPS TWDSYNFAGS FFPPASAAGN HISGYHHQVD QKSSMMTTAP 420
  421 TYPYFGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] PSI-BLAST 42.0 Paired protein (prd)
    2 View Details [141..243] FFAS03 4.02 No description for 2h8rA was found.
    3 View Details [244..427] MSA 3.235997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle