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Protein Overview: CG4563-PA

General Information:
Name(s) found: CG4563-PA / FBpp0072262 [FlyBase]
Description(s) found:
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  • gi|7291786|gb|AAF47206.1| CG4563 [Drosophila melanogaster] [NCBI NR]
  • gi|21430562|gb|AAM50959.1| RE01528p [Drosophila melanogaster] [NCBI NR]
  • gi|20130357|ref|NP_611913.1| CG4563 [Drosophila melanogaster] [NCBI NR]
  • This gene is referred to in FlyBase by the symbol Dmel\CG4563 (CG4563, FBgn0035006). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20338605..20340560. It has the cytological map location 60D1. Based on sequence similarity, it is predicted to have molecular function</span>: 4-coumarate-CoA ligase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: metabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG4563-PA translation from_gene[CG4563 CG4563 FBgn0035006] seq_release:3 mol_weight=59407 cds_boundaries:(2R:19,494,772..19,496,573[-]) aa_length:537 transcript_info:[CG4563-RA seq_release:3] gene_info:[gene symbol:CG4563 FBgn0035006 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W171) CG4563 protein (RE01528p) [DrosMelano7227.FASTAC.txt]
  • (AE003464) CG4563 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG4563-PA [Drosophila melanogaster]gi|21430562|gb|AAM50959.1| RE01528p [Drosophila melanogaster]gi|20130357|ref|NP_611913.1| CG4563-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(20338724..20339675,20339734..20339850,20339917..20340311,20340379..20340528); ID=FBpp0072262; name=CG4563-PA; parent=FBgn0035006,FBtr0072355; dbxref=FlyBase:FBpp0072262,FlyBase_Annotation_IDs:CG4563-PA,GB_protein:AAF47206.1 [fly-100309-contam.fasta]
  • CG4563-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE01528p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(20338724..20339675,20339734..20339850,20339917..20340311,20340379..20340528); ID=FBpp0072262; name=CG4563-PA; parent=FBgn0035006,FBtr0072355; dbxref=FlyBase:FBpp0072262,FlyBase_Annotation_IDs:CG4563-PA,GB_protein:AAF47206.1,REFSEQ:NP_611913,GB_protein:AAF47206; MD5=5ab9432dfd985250d24bdb7be06979d5; length=537; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(20338724..20339675,20339734..20339850,20339917..20340311,20340379..20340528); ID=FBpp0072262; name=CG4563-PA; parent=FBgn0035006,FBtr0072355; dbxref=FlyBase:FBpp0072262,FlyBase_Annotation_IDs:CG4563-PA,GB_protein:AAF47206.1,REFSEQ:NP_611913,GB_protein:AAF47206; MD5=5ab9432dfd985250d24bdb7be06979d5; length=537; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • CG4563 OS=Drosophila melanogaster GN=CG4563 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(20338724..20339675,20339734..20339850,20339917..20340311,20340379..20340528); ID=FBpp0072262; name=CG4563-PA; parent=FBgn0035006,FBtr0072355; dbxref=FlyBase:FBpp0072262,FlyBase_Annotation_IDs:CG4563-PA,GB_protein:AAF47206.1,REFSEQ:NP_611913,GB_protein:AAF47206,FlyMine:FBpp0072262,modMine:FBpp0072262; MD5=5ab9432dfd985250d24bdb7be06979d5; length=537; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • CG4563 OS=Drosophila melanogaster GN=CG4563 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=2R:complement(join(24452856..24453005,24452394..24452788,24452211..24452327,24451201..24452152)); ID=FBpp0072262; name=CG4563-PA; parent=FBgn0035006,FBtr0072355; dbxref=FlyBase:FBpp0072262,FlyBase_Annotation_IDs:CG4563-PA,GB_protein:AAF47206.1,REFSEQ:NP_611913,GB_protein:AAF47206,FlyMine:FBpp0072262,modMine:FBpp0072262; MD5=5ab9432dfd985250d24bdb7be06979d5; length=537; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(24452856..24453005,24452394..24452788,24452211..24452327,24451201..24452152)); ID=FBpp0072262; name=CG4563-PA; parent=FBgn0035006,FBtr0072355; dbxref=FlyBase:FBpp0072262,FlyBase_Annotation_IDs:CG4563-PA,GB_protein:AAF47206.1,REFSEQ:NP_611913,GB_protein:AAF47206,FlyMine:FBpp0072262,modMine:FBpp0072262; MD5=5ab9432dfd985250d24bdb7be06979d5; length=537; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0072262 type=protein; loc=2R:complement(join(24452856..24453005,24452394..24452788,24452211..24452327,24451201..24452152)); ID=FBpp0072262; name=CG4563-PA; parent=FBgn0035006,FBtr0072355; dbxref=FlyBase:FBpp0072262,FlyBase_Annotation_IDs:CG4563-PA,GB_protein:AAF47206.1,REFSEQ:NP_611913,GB_protein:AAF47206,FlyMine:FBpp0072262,modMine:FBpp0072262; MD5=5ab9432dfd985250d24bdb7be06979d5; length=537; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(24452856..24453005,24452394..24452788,24452211..24452327,24451201..24452152)); ID=FBpp0072262; name=CG4563-PA; parent=FBgn0035006,FBtr0072355; dbxref=FlyBase:FBpp0072262,FlyBase_Annotation_IDs:CG4563-PA,GB_protein:AAF47206.1,REFSEQ:NP_611913,GB_protein:AAF47206,UniProt/TrEMBL:Q9W171,FlyMine:FBpp0072262,modMine:FBpp0072262; MD5=5ab9432dfd985250d24bdb7be06979d5; length=537; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 537 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: metabolic process [IEA]
    Molecular Function: 4-coumarate-CoA ligase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTKAVFPTF FNKETQVWSG PPRPTVYDHN TSVGQIVFNS LRCWPTNVIQ ITDDDGTVLT  60
   61 NADMLAYATR IALFFKSEGL TQEDRVGIIA NSSTFVIPVA TACFFQATPF HAVNYSREPA 120
  121 IVQGLYSVTK PKIMFIDGPD YDRIKEITKE WSPKLITLTG KVEGVTSIED LVKPHPAEKI 180
  181 YVPASLATGG DQIAVVLCSS GTAGLPKAVA LSHRHIASTN SLCISTDVLY TSATIDWMTG 240
  241 FSITVMNLTC GFTRIISRRT FSAETALYLV SKYKVTCLAM APWQAYELFT SPLATSEQLE 300
  301 SLKIAFVIGG WISLALLRRA QELLPKTYVM FSYGTTETGV VTINIDHSLE CSVGRLAPGM 360
  361 RIKIQGEDGQ QLGVNQTGEV LIDIGLKWEG YLSNPEDTAT TLQDGWINLG DLGYFDEDNN 420
  421 LYLVDRKKDL LKYKSKHYWP NEIEQIIAEL PEVEHVCVVG VRDARYGDAA GALIIKKEGA 480
  481 EIADQKVIDH VAQRVVVDYK QLNAGVIFVD KFPKNANGKV MRSLAREVFE KTKPITF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..537] PSI-BLAST 108.0 FIREFLY LUCIFERASE IN COMPLEX WITH BROMOFORM

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fatty acid ligase activity
    		•  4.83067429373059 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  4.72692389032116 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  3.29836010446023 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
    		•  2.74744781333102 bayes_pls_golite062009
  • Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
    		•  2.74744781333102 bayes_pls_golite062009
  • luciferin monooxygenase activity
    		•  2.67396462766343 bayes_pls_golite062009
  • ligase activity
    		•  2.49556073715112 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31193176808353 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  1.84544471242521 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  1.68632853816656 bayes_pls_golite062009
  • binding
    		•  1.5312519256537 bayes_pls_golite062009
  • CoA-ligase activity
    		•  1.40182631742133 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.2638869228049 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle