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Protein Overview: FBpp0311714, twi...

General Information:
Name(s) found: FBpp0311714 [FlyBase]
twi-PB / FBpp0099476 [FlyBase]
twi-PA / FBpp0071864 [FlyBase]
Description(s) found:
Found 41 descriptions.
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  • type=protein; loc=2R:join(18934006..18935228,18935350..18935599); ID=FBpp0311714; name=twi-PC; parent=FBgn0003900,FBtr0345653; dbxref=FlyBase:FBpp0311714,FlyBase_Annotation_IDs:CG2956-PC; MD5=c232033e01f5e6e01cc53fa60fb1d040; length=490; release=r5.56; species=Dmel; [FlyBase]
  • The gene twist is referred to in FlyBase by the symbol Dmel\twi (CG2956, FBgn0003900). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18933631..18935849. It has the cytological map location 59C2. There is experimental evidence that it has the molecular function</span>: specific transcriptional repressor activity; protein heterodimerization activity; protein homodimerization activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: mesodermal cell fate commitment; muscle fiber development; Malpighian tubule morphogenesis; regulation of striated muscle tissue development; salivary gland morphogenesis; mesoderm development. 55 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: organ system; primordium; adult segment; adult mesothoracic segment; portion of tissue; late extended germ band embryo; germ layer; adult somatic muscle; nervous system; muscle founder cell; endoderm derivative. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene twist is referred to in FlyBase by the symbol Dmel\twi (CG2956, FBgn0003900). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18933631..18935849. It has the cytological map location 59C2. There is experimental evidence that it has the molecular function</span>: specific transcriptional repressor activity; protein heterodimerization activity; protein homodimerization activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: mesodermal cell fate commitment; muscle fiber development; Malpighian tubule morphogenesis; regulation of striated muscle tissue development; salivary gland morphogenesis; mesoderm development. 55 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: organ system; primordium; adult segment; adult mesothoracic segment; portion of tissue; late extended germ band embryo; germ layer; adult somatic muscle; nervous system; muscle founder cell; endoderm derivative. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 490 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: ventral furrow formation [TAS]
    Malpighian tubule morphogenesis [IMP]
    mesoderm development [IEP][NAS][TAS]
    ectoderm and mesoderm interaction [NAS]
    anterior midgut invagination [NAS]
    dorsal/ventral axis specification [TAS]
    positive regulation of transcription from RNA polymerase II promoter [NAS]
    regulation of transcription [IEA]
    mesodermal cell fate determination [TAS]
    regulation of transcription from RNA polymerase II promoter [ISS]
    gastrulation [NAS]
    mesodermal cell fate specification [TAS]
    muscle fiber development [IMP]
    salivary gland morphogenesis [IMP]
    heart development [TAS]
    mesodermal cell fate commitment [IMP][TAS]
    regulation of striated muscle tissue development [IMP]
    gastrulation involving germ band extension [TAS]
    Molecular Function: DNA binding [IDA][NAS]
    protein homodimerization activity [IPI]
    protein heterodimerization activity [IPI]
    specific RNA polymerase II transcription factor activity [ISS]
    transcription activator activity [NAS]
    specific transcriptional repressor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSARSVSPK VLLDISYKPT LPNIMELQNN VIKLIQVEQQ AYMQSGYQLQ HQQQHLHSHQ  60
   61 HHQQHHQQQH AQYAPLPSEY AAYGITELED TDYNIPSNEV LSTSSNQSAQ STSLELNNNN 120
  121 TSSNTNSSGN NPSGFDGQAS SGSSWNEHGK RARSSGDYDC QTGGSLVMQP EHKKLIHQQQ 180
  181 QQQQQHQQQI YVDYLPTTVD EVASAQSCPG VQSTCTSPQS HFDFPDEELP EHKAQVFLPL 240
  241 YNNQQQQSQQ LQQQQPHQQS HAQMHFQNAY RQSFEGYEPA NSLNGSAYSS SDRDDMEYAR 300
  301 HNALSSVSDL NGGVMSPACL ADDGSAGSLL DGSDAGGKAF RKPRRRLKRK PSKTEETDEF 360
  361 SNQRVMANVR ERQRTQSLND AFKSLQQIIP TLPSDKLSKI QTLKLATRYI DFLCRMLSSS 420
  421 DISLLKALEA QGSPSAYGSA SSLLSAAANG AEADLKCLRK ANGAPIIPPE KLSYLFGVWR 480
  481 MEGDAQHQKA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..243] MSA 3.167995 View MSA. No confident structure predictions are available.
    2 View Details [244..351] deduced N/A No confident structure predictions are available.
    3 View Details [352..490] PSI-BLAST 16.0 Myod B/HLH domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • transcription activator activity
    		•  3.87875547821718 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.42035985454056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.39500382187264 bayes_pls_golite062009
  • protein binding
    		•  2.64975291677725 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.42306484786159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • promoter binding
    		•  0.8576109846276 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.53175615551166 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.20674648626116 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle