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Protein Overview: CycB-PA

General Information:
Name(s) found: CycB-PA / FBpp0071822 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene Cyclin B is referred to in FlyBase by the symbol Dmel\CycB (CG3510, FBgn0000405). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18691027..18694490. It has the cytological map location 59B2. There is experimental evidence that it has the molecular function</span>: cyclin-dependent protein kinase regulator activity. There is experimental evidence that it is involved in the biological process</span>: cytokinesis after mitosis; cytokinesis; syncytial blastoderm mitotic cell cycle; attachment of spindle microtubules to kinetochore; cellular response to DNA damage stimulus; mitotic chromosome movement towards spindle pole; cellular process; mitotic anaphase B. 52 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: cleavage stage embryo; cell cycle; organ system; blastoderm embryo; peripheral nervous system; gastrula embryo; syncytial blastoderm embryo; nervous system; aster; embryonic segment; protein complex; spiracle; external compound sense organ; adult segment. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 530 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    spindle midzone [IDA]
    cytoplasm [TAS]
    nuclear cyclin-dependent protein kinase holoenzyme complex [NAS]
    pole plasm [TAS]
    spindle [TAS]
    chromosome, centromeric region [TAS]
    Biological Process: G2/M transition of mitotic cell cycle [NAS]
    embryonic development via the syncytial blastoderm [TAS]
    cytokinesis after mitosis [IMP]
    attachment of spindle microtubules to kinetochore [IMP][TAS]
    syncytial blastoderm mitotic cell cycle [IGI]
    mitotic anaphase B [IMP]
    cytokinesis [IMP]
    mitotic chromosome movement towards spindle pole [IMP]
    response to DNA damage stimulus [IMP]
    cellular process [IMP]
    Molecular Function: cyclin-dependent protein kinase regulator activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVGTTLKMRG DENASENFKQ VQLKKLTVPS MEATTKRAAL GDLQNRGISR PIAAKDAAQK  60
   61 DSKDLKLTDA LRNAKARVDS HWKKQPLGST NGNGNGAVPP KVNEGGVSAF LRSNSVRNRV 120
  121 PTKTTVEPTK VTVKSSSSEN VNEPTLKRED SNLSKKSLTK LRAALAKPVM GVSGIRREPV 180
  181 AVSRKEAETK KELPETKKDS LEVKKDATRM PLIRGNSAVT TTTSTMPTTM SLSSKRLAGI 240
  241 EDIDANDKEN LVLVSEYVND IYDYLYQVEL EQPIHKDHLA GQKEVSHKMR AVLIDWINEV 300
  301 HLQFHLAAET FQLAVAIIDR YLQVVKDTKR TYLQLVGVTA LFIATKYEEL FPPAIGDFVF 360
  361 ITDDTYTARQ IRQMELQIFK AIDCNLSRPL PIHFLRRYSK AAGAEDEHHT MSKYFIELAS 420
  421 VDYEMATYRP SEIAAASLFL SLHLLNGNHR AGTGFNDRHW TPTLTFYSRY SAAHLRPITR 480
  481 LIAKLARDAP QAKLKAIYNK YQGSKFQKIA LRTELTGALM DSIVGQSQRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] MSA 5.270996 View MSA. No confident structure predictions are available.
    2 View Details [143..225] deduced N/A No confident structure predictions are available.
    3 View Details [226..530] PSI-BLAST 69.154902 No description for 2b9rA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle