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Protein Overview: dve-PA

General Information:
Name(s) found: dve-PA / FBpp0071689 [FlyBase]
Description(s) found:
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  • gi|92109866|gb|ABE73257.1| IP14647p [Drosophila melanogaster] [NCBI NR]
  • gi|7291399|gb|AAF46827.1| defective proventriculus, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|17137350|ref|NP_477242.1| defective proventriculus, isoform A [Drosophila melanogaster] [NCBI NR]
  • The gene defective proventriculus is referred to in FlyBase by the symbol Dmel\dve (CG5799, FBgn0020307). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18131468..18173982. It has the cytological map location 58D2. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity; AT DNA binding. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing morphogenesis; midgut development. 32 alleles are reported. The phenotypes of these alleles are annotated with: proventriculus inner layer; dorsal mesothoracic disc; cuprophilic cell; proventriculus outer layer; wing. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG5799-PA translation from_gene[CG5799 dve FBgn0020307] seq_release:3 mol_weight=111983 cds_boundaries:(2R:17,288,233..17,328,908[+]) aa_length:1024 transcript_info:[CG5799-RA seq_release:3] gene_info:[gene symbol:dve FLAGGED_PROBLEMATIC FBgn0020307 g [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W268) DVE protein [DrosMelano7227.FASTAC.txt]
  • (AE003456) dve gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5799-PA, isoform A [Drosophila melanogaster]gi|17137350|ref|NP_477242.1| CG5799-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(18132187..18132252,18150270..18150948,18168172..18168381,18168495..18168724,18170853..18172582,18172706..18172865); ID=FBpp0071689; name=dve-PA; parent=FBgn0020307,FBtr0071775; dbxref=FlyBase:FBpp0071689,FlyBase_Annotation_IDs:CG [fly-100309-contam.fasta]
  • defective proventriculus CG5799-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • IP14647p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG5799-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(18132187..18132252,18150270..18150948,18168172..18168381,18168495..18168724,18170853..18172582,18172706..18172865); ID=FBpp0071689; name=dve-PA; parent=FBgn0020307,FBtr0071775; dbxref=FlyBase:FBpp0071689,FlyBase_Annotation_IDs:CG5799-PA,GB_protein:AAF46827.1,REFSEQ:NP_477242,GB_protein:AAF46827; MD5=a2aa8fa6284238780832ab13da4e9793; length=1024; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(18132187..18132252,18150270..18150948,18168172..18168381,18168495..18168724,18170853..18172582,18172706..18172865); ID=FBpp0071689; name=dve-PA; parent=FBgn0020307,FBtr0071775; dbxref=FlyBase:FBpp0071689,FlyBase_Annotation_IDs:CG5799-PA,GB_protein:AAF46827.1,REFSEQ:NP_477242,GB_protein:AAF46827; MD5=a2aa8fa6284238780832ab13da4e9793; length=1024; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Defective proventriculus, isoform A OS=Drosophila melanogaster GN=dve PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(18132187..18132252,18150270..18150948,18168172..18168381,18168495..18168724,18170853..18172582,18172706..18172865); ID=FBpp0071689; name=dve-PA; parent=FBgn0020307,FBtr0071775; dbxref=FlyBase:FBpp0071689,FlyBase_Annotation_IDs:CG5799-PA,GB_protein:AAF46827.1,REFSEQ:NP_477242,GB_protein:AAF46827,FlyMine:FBpp0071689,modMine:FBpp0071689; MD5=a2aa8fa6284238780832ab13da4e9793; length=1024; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(22244682..22244747,22262765..22263443,22280667..22280876,22280990..22281219,22283348..22285077,22285201..22285360); ID=FBpp0071689; name=dve-PA; parent=FBgn0020307,FBtr0071775; dbxref=FlyBase:FBpp0071689,FlyBase_Annotation_IDs:CG5799-PA,GB_protein:AAF46827.1,REFSEQ:NP_477242,GB_protein:AAF46827,FlyMine:FBpp0071689,modMine:FBpp0071689; MD5=a2aa8fa6284238780832ab13da4e9793; length=1024; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(22244682..22244747,22262765..22263443,22280667..22280876,22280990..22281219,22283348..22285077,22285201..22285360); ID=FBpp0071689; name=dve-PA; parent=FBgn0020307,FBtr0071775; dbxref=FlyBase:FBpp0071689,FlyBase_Annotation_IDs:CG5799-PA,GB_protein:AAF46827.1,REFSEQ:NP_477242,GB_protein:AAF46827,FlyMine:FBpp0071689,modMine:FBpp0071689; MD5=a2aa8fa6284238780832ab13da4e9793; length=1024; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0071689 type=protein; loc=2R:join(22244682..22244747,22262765..22263443,22280667..22280876,22280990..22281219,22283348..22285077,22285201..22285360); ID=FBpp0071689; name=dve-PA; parent=FBgn0020307,FBtr0071775; dbxref=FlyBase:FBpp0071689,FlyBase_Annotation_IDs:CG5799-PA,GB_protein:AAF46827.1,REFSEQ:NP_477242,GB_protein:AAF46827,FlyMine:FBpp0071689,modMine:FBpp0071689; MD5=a2aa8fa6284238780832ab13da4e9793; length=1024; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(22244682..22244747,22262765..22263443,22280667..22280876,22280990..22281219,22283348..22285077,22285201..22285360); ID=FBpp0071689; name=dve-PA; parent=FBgn0020307,FBtr0071775; dbxref=FlyBase:FBpp0071689,FlyBase_Annotation_IDs:CG5799-PA,GB_protein:AAF46827.1,REFSEQ:NP_477242,GB_protein:AAF46827,UniProt/TrEMBL:Q9W268,FlyMine:FBpp0071689,modMine:FBpp0071689; MD5=a2aa8fa6284238780832ab13da4e9793; length=1024; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1024 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    Biological Process: midgut development [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    regulation of transcription, DNA-dependent [IEA][ISS]
    regulation of transcription [IEA][TAS]
    Molecular Function: transcription factor activity [ISS][NAS][TAS]
    AT DNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFQSAMETF AEAWVAANAG QQSQALALTR AVNAAAVVAS ANAKSPNASS SASASLADLA  60
   61 VKKEHSISPP HSVVSVGVGV AGEDQHRRSS LQGVQEKLTQ LQMQQQHHQQ QQQQQQQQQQ 120
  121 QHQQQQQHHH HQQQAQQAGA GVGSGELAGR RSSEGTPPTA HPPTNSEGQA LSSSTASSSQ 180
  181 NATPKSDRER ERERERDREE RVERGSISCL PPAALGMAVG VQQAQHQEKL LSHPALDSRR 240
  241 EFDVSKVNPK SLPLHCVVES VHSLHASLTI DTRQPWKRRP NIETDSYVII AAATPWSEIV 300
  301 QTALQRLGYS QEVANTARGS LIIKHWKPIP LEQISDNPAV PVSDIVGELT SVITLRIVIL 360
  361 RPKTSPFGEI KDKLLKLLVL QSHAVLRSTG CPLDEVTLSQ ICRSSHQNTY ALPGGEISDE 420
  421 LRRKFDQWWS NQLSPQATAM TPKMLPFMTG PSAVPVPVAV PGEMDFPVGT AMAAAAAAAA 480
  481 HAAAAGGAAG GNPLGSMGSR ESLLLANEAA HHAGAGQAPG PGHHGSMLVH PMHASMHHHH 540
  541 HHGGGGGHGP PYPNQKTRMR TSFDPEMELP KLQKWFADNP HPSRQQIQTY VVQLNALESR 600
  601 RGRKPLDVNN VVYWFKNARA AQKRAEMRGG SLGSAISALG HAAMNGYLSQ HAPLGQNSSS 660
  661 SAGSQPMSMG NLSMSHDYLK SPLSLKSEDI DTMSQHSDDM DEEQSRPNTP QLPLSLTTHE 720
  721 RHRSSPLMDE DEDEAGEQQQ PQEAKSDGMN GSVKDEERQE KSRDELQDNE KENSNGEDRH 780
  781 LDADAQMEAS SNLNNNHNNS SLHIEQEVGS TPKRSTPKEE DDDLDMDEDE EDNENDASHL 840
  841 DEFRSPSPDL AGGVVPHKDQ LPFPMVPNSM FSQSFMYMSH YIPAFGQAAA GHPHHHAAAA 900
  901 AAAAGIQPNA LMGGGGLNLS SISNEERRKR NRTFIDPVTE VPKLEQWFAM NTHPSHNLIL 960
  961 KYTEDLNTMP YRQKFPRLES KNVQFWFKNR RAKCKRLKMS LYDSNQCAQL GGLGSFVPKY1020
 1021 EERD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..249] deduced N/A No confident structure predictions are available.
    2 View Details [250..440] MSA 1.027931 View MSA. No confident structure predictions are available.
    3 View Details [441..538] deduced N/A No confident structure predictions are available.
    4 View Details [539..873] PSI-BLAST 4.045757 Botulinum neurotoxin
    5 View Details [874..1024] FFAS03 4.27 TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.40096962515027 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.15398264148864 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.95513305822187 bayes_pls_golite062009
  • DNA binding
    		•  1.80079581406991 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15427978494805 bayes_pls_golite062009
  • protein binding
    		•  0.757492117682468 bayes_pls_golite062009
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  4.86538715425734 bayes_pls_golite062009
  • DNA binding
    		•  4.40186699787632 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.28652307290136 bayes_pls_golite062009
  • transcription factor activity
    		•  3.78935192723648 bayes_pls_golite062009
  • binding
    		•  2.92574888336072 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.15328641013602 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.00875399167309 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.69615348178304 bayes_pls_golite062009
  • transcription activator activity
    		•  1.5973137667873 bayes_pls_golite062009
  • transcription factor binding
    		•  1.24678737091956 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.865913662624162 bayes_pls_golite062009
  • chromatin binding
    		•  0.82130998265632 bayes_pls_golite062009
  • protein binding
    		•  0.795494287543952 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.691780246385357 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0723215858239072 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle