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Protein Overview: MED16-PA

General Information:
Name(s) found: MED16-PA / FBpp0071684 [FlyBase]
Description(s) found:
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  • gi|94400642|gb|ABF17924.1| FI01002p [Drosophila melanogaster] [NCBI NR]
  • gi|74872316|sp|Q9W278.2|MED16_DROME RecName: Full=Mediator of RNA polymerase II transcription subunit 16; AltName: Full=Mediator complex subunit 16 [NCBI NR]
  • gi|24657790|ref|NP_611650.2| mediator complex subunit 16 [Drosophila melanogaster] [NCBI NR]
  • gi|21626540|gb|AAF46815.2| mediator complex subunit 16 [Drosophila melanogaster] [NCBI NR]
  • Mediator of RNA polymerase II transcription subunit 16 OS=Drosophila melanogaster GN=MED16 PE=1 SV=2 [Swiss-Prot]
  • The gene Mediator complex subunit 16 is referred to in FlyBase by the symbol Dmel\MED16 (CG5465, FBgn0034707). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18070651..18073397. It has the cytological map location 58C5-58C7. Based on sequence similarity, it is predicted to have molecular function</span>: RNA polymerase II transcription mediator activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: transcription initiation from RNA polymerase II promoter; transcription from RNA polymerase II promoter. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG5465-PA translation from_gene[CG5465 Trap95 FBgn0034707] seq_release:3 mol_weight=89980 cds_boundaries:(2R:17,226,762..17,229,215[+]) aa_length:818 transcript_info:[CG5465-RA seq_release:3] gene_info:[gene symbol:Trap95 FBgn0034707 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W278) CG5465 protein [DrosMelano7227.FASTAC.txt]
  • CG5465-PA [Drosophila melanogaster]gi|24657790|ref|NP_611650.2| CG5465-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:18070716..18073172; ID=FBpp0071684; name=MED16-PA; parent=FBgn0034707,FBtr0071770; dbxref=FlyBase:FBpp0071684,FlyBase_Annotation_IDs:CG5465-PA,GB_protein:AAF46815.2,REFSEQ:NP_611650,GB_protein:AAF46815; MD5=15c75787e7cbadfbb80a2900028 [fly-100309-contam.fasta]
  • Mediator complex subunit 16 CG5465-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • FI01002p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG5465-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:18070716..18073172; ID=FBpp0071684; name=MED16-PA; parent=FBgn0034707,FBtr0071770; dbxref=FlyBase:FBpp0071684,FlyBase_Annotation_IDs:CG5465-PA,GB_protein:AAF46815.2,REFSEQ:NP_611650,GB_protein:AAF46815; MD5=15c75787e7cbadfbb80a2900028ee87a; length=818; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:18070716..18073172; ID=FBpp0071684; name=MED16-PA; parent=FBgn0034707,FBtr0071770; dbxref=FlyBase:FBpp0071684,FlyBase_Annotation_IDs:CG5465-PA,GB_protein:AAF46815.2,REFSEQ:NP_611650,GB_protein:AAF46815; MD5=15c75787e7cbadfbb80a2900028ee87a; length=818; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:18070716..18073172; ID=FBpp0071684; name=MED16-PA; parent=FBgn0034707,FBtr0071770; dbxref=FlyBase:FBpp0071684,FlyBase_Annotation_IDs:CG5465-PA,GB_protein:AAF46815.2,REFSEQ:NP_611650,GB_protein:AAF46815,FlyMine:FBpp0071684,modMine:FBpp0071684; MD5=15c75787e7cbadfbb80a2900028ee87a; length=818; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:22183211..22185667; ID=FBpp0071684; name=MED16-PA; parent=FBgn0034707,FBtr0071770; dbxref=FlyBase:FBpp0071684,FlyBase_Annotation_IDs:CG5465-PA,GB_protein:AAF46815.2,REFSEQ:NP_611650,GB_protein:AAF46815,FlyMine:FBpp0071684,modMine:FBpp0071684; MD5=15c75787e7cbadfbb80a2900028ee87a; length=818; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:22183211..22185667; ID=FBpp0071684; name=MED16-PA; parent=FBgn0034707,FBtr0071770; dbxref=FlyBase:FBpp0071684,FlyBase_Annotation_IDs:CG5465-PA,GB_protein:AAF46815.2,REFSEQ:NP_611650,GB_protein:AAF46815,FlyMine:FBpp0071684,modMine:FBpp0071684; MD5=15c75787e7cbadfbb80a2900028ee87a; length=818; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0071684 type=protein; loc=2R:22183211..22185667; ID=FBpp0071684; name=MED16-PA; parent=FBgn0034707,FBtr0071770; dbxref=FlyBase:FBpp0071684,FlyBase_Annotation_IDs:CG5465-PA,GB_protein:AAF46815.2,REFSEQ:NP_611650,GB_protein:AAF46815,FlyMine:FBpp0071684,modMine:FBpp0071684; MD5=15c75787e7cbadfbb80a2900028ee87a; length=818; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:22183211..22185667; ID=FBpp0071684; name=MED16-PA; parent=FBgn0034707,FBtr0071770; dbxref=FlyBase:FBpp0071684,FlyBase_Annotation_IDs:CG5465-PA,GB_protein:AAF46815.2,REFSEQ:NP_611650,GB_protein:AAF46815,UniProt/Swiss-Prot:Q9W278,FlyMine:FBpp0071684,modMine:FBpp0071684; MD5=15c75787e7cbadfbb80a2900028ee87a; length=818; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 818 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    mediator complex [ISS]
    Biological Process: transcription from RNA polymerase II promoter [ISS]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: transcription cofactor activity [NAS]
    RNA polymerase II transcription mediator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTILYKVEGK EFSKDSVFPH KKVLCSVSAR NIVAFSALQS AIFPASHGGD AGDGSLPGAG  60
   61 LAVGASNSHV YVCDIVTPWE YYKVCSSKSL ISVLQWSPNG EQLLLGYVGG RVEIWQPRNQ 120
  121 SINLWVLQYY ATVPSEDIIE AQFFQNGKGV IFNALKKDHT YYAEKFERVE QQRPTLSGFG 180
  181 GVASEGCVLL TSSGLLAAFS LPAIQKTSAA GADGPAHEVV ELTPALHSIG ISRSFIEHCS 240
  241 MTPSPSGALN IAFSCGWQQQ LVQCFKVSLS LEGELGLEQH LAIKSESQTS IFLGPLDGRR 300
  301 ISHLKWTRIA NEDVIFIAYA CPDGAGSQLE QWTLTRRHQS VHALLQGGGG ANNKPNEFVQ 360
  361 SESWEQVGKV QLNASLADIS VTRLSVSTPD SCQVYAILQD NSVQVLEPNS MKQLNHTQFD 420
  421 RLSDASGAVK FVSGDLTPSS QILLIFDSHA QLYAMQAPLP KQGGSGLLLL EYCIVTGCDA 480
  481 SDVLLLNLGN LEALVEKLTD NFTRQPSFVR HFYYANFLAL KSNICRMQQQ EFDNLIILHA 540
  541 ISTTFKSLLR PSDLGFQDKG PADNLAIKLA ESIPDVDTVM LNLDAKDFTV EPVMLQSLQQ 600
  601 LIQWVTDLAL NMLHRLPEEV MKTKLSGKRP SYDISRDIVA ISSLRELLVM IRIWGLLNTQ 660
  661 CLPVYTKTMD NIDVLVILFR LLTRLAQNPA EPDEMLLDEC SLLSKQLLIP QPTKFNPTTL 720
  721 LSAQGFAAVK SGQLQFTSME EPTCLQDMET EEVVFASSVK DGVSNLQLGA RPSHIRRCAR 780
  781 CGFVFVNNAS KVAKTSALKA WFSKWLHCHC GGFWKQVH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..688] FFAS03 0.977 Actin interacting protein 1
    2 View Details [689..818] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.60759822784178 bayes_pls_golite062009
  • binding
    		•  2.38386546684697 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36560618519891 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30172153305516 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  2.27070335649585 bayes_pls_golite062009
  • DNA binding
    		•  1.74970945772818 bayes_pls_golite062009
  • protein binding
    		•  1.14503622489775 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10790917305704 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.673044943383302 bayes_pls_golite062009
    		• 0.648807338780975 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.561205988591905 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.530674315734974 bayes_pls_golite062009
  • transcription factor binding
    		•  0.421428497325728 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.295072505361604 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.203779337313278 bayes_pls_golite062009
  • chromatin binding
    		•  0.0857162436144714 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.00328955300255629 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle