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View Structure Prediction Details

Protein: MED16-PA
Organism: Drosophila melanogaster
Length: 818 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED16-PA.

Description E-value Query
Range
Subject
Range
gi|9937472 - gi|9937472|gb|AAG02459.1|AF289994_1 thyroid hormone receptor-associated protein TRAP95 [Drosophila m...
1280.0 [0..1] [818..1]

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Predicted Domain #1
Region A:
Residues: [1-688]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTILYKVEGK EFSKDSVFPH KKVLCSVSAR NIVAFSALQS AIFPASHGGD AGDGSLPGAG  60
   61 LAVGASNSHV YVCDIVTPWE YYKVCSSKSL ISVLQWSPNG EQLLLGYVGG RVEIWQPRNQ 120
  121 SINLWVLQYY ATVPSEDIIE AQFFQNGKGV IFNALKKDHT YYAEKFERVE QQRPTLSGFG 180
  181 GVASEGCVLL TSSGLLAAFS LPAIQKTSAA GADGPAHEVV ELTPALHSIG ISRSFIEHCS 240
  241 MTPSPSGALN IAFSCGWQQQ LVQCFKVSLS LEGELGLEQH LAIKSESQTS IFLGPLDGRR 300
  301 ISHLKWTRIA NEDVIFIAYA CPDGAGSQLE QWTLTRRHQS VHALLQGGGG ANNKPNEFVQ 360
  361 SESWEQVGKV QLNASLADIS VTRLSVSTPD SCQVYAILQD NSVQVLEPNS MKQLNHTQFD 420
  421 RLSDASGAVK FVSGDLTPSS QILLIFDSHA QLYAMQAPLP KQGGSGLLLL EYCIVTGCDA 480
  481 SDVLLLNLGN LEALVEKLTD NFTRQPSFVR HFYYANFLAL KSNICRMQQQ EFDNLIILHA 540
  541 ISTTFKSLLR PSDLGFQDKG PADNLAIKLA ESIPDVDTVM LNLDAKDFTV EPVMLQSLQQ 600
  601 LIQWVTDLAL NMLHRLPEEV MKTKLSGKRP SYDISRDIVA ISSLRELLVM IRIWGLLNTQ 660
  661 CLPVYTKTMD NIDVLVILFR LLTRLAQN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.977
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.60759822784178 bayes_pls_golite062009
binding 2.38386546684697 bayes_pls_golite062009
transcription regulator activity 2.36560618519891 bayes_pls_golite062009
nucleic acid binding 2.30172153305516 bayes_pls_golite062009
transcription initiation factor activity 2.27070335649585 bayes_pls_golite062009
DNA binding 1.74970945772818 bayes_pls_golite062009
protein binding 1.14503622489775 bayes_pls_golite062009
transcription factor activity 1.10790917305704 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.673044943383302 bayes_pls_golite062009
0.648807338780975 bayes_pls_golite062009
transcription repressor activity 0.561205988591905 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.530674315734974 bayes_pls_golite062009
transcription factor binding 0.421428497325728 bayes_pls_golite062009
nucleotidyltransferase activity 0.295072505361604 bayes_pls_golite062009
transcription cofactor activity 0.203779337313278 bayes_pls_golite062009
chromatin binding 0.0857162436144714 bayes_pls_golite062009
transcription corepressor activity 0.00328955300255629 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [689-818]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAEPDEMLLD ECSLLSKQLL IPQPTKFNPT TLLSAQGFAA VKSGQLQFTS MEEPTCLQDM  60
   61 ETEEVVFASS VKDGVSNLQL GARPSHIRRC ARCGFVFVNN ASKVAKTSAL KAWFSKWLHC 120
  121 HCGGFWKQVH 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle