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Protein Overview: NC2alpha-PB

General Information:
Name(s) found: NC2alpha-PB / FBpp0071584 [FlyBase]
Description(s) found:
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  • gi|25012178|gb|AAN71206.1| GH27814p [Drosophila melanogaster] [NCBI NR]
  • gi|24657222|ref|NP_726102.1| NC2alpha, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|21645308|gb|AAM70930.1| NC2alpha, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene NC2Ã?&#142;Ã?± is referred to in FlyBase by the symbol Dmel\NC2Ã?&#142;Ã?± (CG10318, FBgn0034650). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17557673..17559098. It has the cytological map location 57F7. It is reported to have molecular function</span>: general transcriptional repressor activity. It is reported to be involved in the biological process</span>: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG10318-PB translation from_gene[CG10318 NC2alpha FBgn0034650] seq_release:3 mol_weight=33909 cds_boundaries:(2R:16,714,065..16,715,027[+]) aa_length:321 transcript_info:[CG10318-RB seq_release:3] gene_info:[gene symbol:NC2alpha FBgn0034650 gene_bound [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8MLV5) CG10318-PB (GH27814p) [DrosMelano7227.FASTAC.txt]
  • (AE003454) CG10318 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG10318-PB, isoform B [Drosophila melanogaster]gi|24657222|ref|NP_726102.1| CG10318-PB [Drosophila melanogaster]gi|25012178|gb|AAN71206.1| GH27814p [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:17558019..17558984; ID=FBpp0071584; name=NC2alpha-PB; parent=FBgn0034650,FBtr0071667; dbxref=FlyBase:FBpp0071584,FlyBase_Annotation_IDs:CG10318-PB,GB_protein:AAM70930.1,REFSEQ:NP_726102,GB_protein:AAM70930; MD5=60acd032a0c960f9d4765c1 [fly-100309-contam.fasta]
  • CG10318-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • NC2alpha CG10318-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • GH27814p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:17558019..17558984; ID=FBpp0071584; name=NC2alpha-PB; parent=FBgn0034650,FBtr0071667; dbxref=FlyBase:FBpp0071584,FlyBase_Annotation_IDs:CG10318-PB,GB_protein:AAM70930.1,REFSEQ:NP_726102,GB_protein:AAM70930; MD5=60acd032a0c960f9d4765c1ce6880f8e; length=321; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:17558019..17558984; ID=FBpp0071584; name=NC2alpha-PB; parent=FBgn0034650,FBtr0071667; dbxref=FlyBase:FBpp0071584,FlyBase_Annotation_IDs:CG10318-PB,GB_protein:AAM70930.1,REFSEQ:NP_726102,GB_protein:AAM70930; MD5=60acd032a0c960f9d4765c1ce6880f8e; length=321; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • GH27814p OS=Drosophila melanogaster GN=NC2alpha PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:17558019..17558984; ID=FBpp0071584; name=NC2alpha-PB; parent=FBgn0034650,FBtr0071667; dbxref=FlyBase:FBpp0071584,FlyBase_Annotation_IDs:CG10318-PB,GB_protein:AAM70930.1,REFSEQ:NP_726102,GB_protein:AAM70930,FlyMine:FBpp0071584,modMine:FBpp0071584; MD5=60acd032a0c960f9d4765c1ce6880f8e; length=321; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • GH27814p OS=Drosophila melanogaster GN=NC2alpha PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 321 amino acids

    Gene Ontology:
    Cellular Component: negative cofactor 2 complex [NAS]
    intracellular [IEA]
    Biological Process: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [NAS]
    Molecular Function: sequence-specific DNA binding [IEA]
    general transcriptional repressor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSDEEIGKV AQAVPVIISR TLELFVESLL TKTLRITNAR NAKTLSPSHM RQCIVSEKRF  60
   61 DFLKELVRNI PDISVAEEAA YNEDDVLRSS PEEQYPDSDT PYDLSLPSTS MRSQANGTAA 120
  121 YMRSMSLNNG AGSGGGAAAT KRQFQSQHST QETPTTSTTL PAKLARSGSM PAYTPRGRPP 180
  181 NHLKKQSVQL DTAIPAPICN YELNKPIVKI DYSHVQMPTA NLCTPDASDS GSGSGAGSGA 240
  241 FNFDIAAPVI NIDLTNIVAG GAPGSGVPPA SIGLPAATPG DNNNVNQMAG KSSAPIIPKA 300
  301 TAASATPTET VFELDEDYDN I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] PSI-BLAST 34.154902 Nuclear transcription factor Y subunit gamma (Nf-Yc2)
    2 View Details [79..203] PSI-BLAST 3.09691 Sec24
    3 View Details [204..321] MSA 1.152972 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  6.43582244485566 bayes_pls_golite062009
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.28941584139552 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.3574713307436 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  1.57176056919918 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.30859203490073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • protein binding
    		•  1.07873333188144 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0852726470007639 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle