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Protein Overview: cv-2-PA

General Information:
Name(s) found: cv-2-PA / FBpp0071536 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene crossveinless 2 is referred to in FlyBase by the symbol Dmel\cv-2 (CG15671, FBgn0000395). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17242520..17266967. It has the cytological map location 57D12-57E1. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing vein specification; imaginal disc-derived wing morphogenesis. 16 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; crossvein; wing vein; anterior crossvein. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 751 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: imaginal disc-derived wing morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IMP]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCCQSSGQWK FPAQQPRKSL ASRRRHTGFR PSTQLLILIA VLLALLQGRT VDAGAGDSLS  60
   61 GVRQSCSNEG EEVQLKNQPQ IFTCFKCECQ NGFVNCRDTC PPVNDCYILD KSNGTCCRRC 120
  121 KGCSFRGMSY ESGSEWNDPE DPCKTYKCVA TVVTETIQKC YSQCDNNQLQ PPRPGECCPT 180
  181 CQGCKINGQT VAEGHEVDAS IDDRCLVCQC RGTQLTCSKK TCPVLPCPMS KQIKRPDECC 240
  241 PRCPQNHSFL PVPGKCLFNK SVYPEKTQFM PDRCTNCTCL NGTSVCQRPT CPILECAPEF 300
  301 QEPDGCCPRC AVAEVRSECS LDGIVYQNNE TWDMGPCRSC RCNGGTIRCA QMRCPAVKCR 360
  361 ANEELKQPPG ECCQRCVETA GTCTVFGDPH FRTFDGKFFS FQGSCKYLLA SDCMGKTFHI 420
  421 RLTNEGRGTR RASWAKTVTL SLRNLKVNLG QRMRVKVNGT RVTLPYFVVA GGQNVTIERL 480
  481 ANGGAVMLRS EMGLTLEWNG AGFLQVSVPA KFKKRLCGLC GNFNGSSRDD LTGKDGRSHG 540
  541 DDEVWHFANS WKVGGPKSCS RKREFLAATP TCDKRKSNFY CHPLSVPALF GECNERLNPE 600
  601 NYKAACRMDV CECPSGDCHC DSFAAYAHEC RRLGVQLPDW RSATNCPAGW RRNATLSSFK 660
  661 GNQFYGDPSF SRMKGRRQKN HQLRLQLQQE QQQRSKQGQK GRHKPGGHNQ LDRQGHNGLD 720
  721 KDQLQKEFIL KHVPSSFLYP RAPDRTPPPL H

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] PSI-BLAST 6.522879 NMR structure of the human NOTCH-1 ligand binding region
    2 View Details [97..513] PSI-BLAST 7.69897 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    3 View Details [514..595] deduced N/A No confident structure predictions are available.
    4 View Details [596..751] FFAS03 1.67 Anticoagulant protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • receptor binding
    		•  4.60755835611133 bayes_pls_golite062009
  • growth factor activity
    		•  4.38305031783896 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  3.49243532917035 bayes_pls_golite062009
  • heparin binding
    		•  3.0535264040722 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.92645080817676 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.79319890241656 bayes_pls_golite062009
  • binding
    		•  2.07793256968292 bayes_pls_golite062009
  • pattern binding
    		•  1.7855850180475 bayes_pls_golite062009
  • protein binding
    		•  1.71989387545809 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.75634551012462 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  0.65339109098708 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.6530199085873 bayes_pls_golite062009
  • transcription factor binding
    		•  0.556175571276939 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.470263535896705 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.5247816153916 bayes_pls_golite062009
  • protein binding
    		•  0.833726797288547 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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