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Protein Overview: Xpd-PC, Xpd-PB

General Information:
Name(s) found: Xpd-PC / FBpp0291089 [FlyBase]
Xpd-PB / FBpp0071504 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Xeroderma pigmentosum D is referred to in FlyBase by the symbol Dmel\Xpd (CG9433, FBgn0015844). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17058460..17062009. It has the cytological map location 57C7. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity; ATP-dependent 5'-3' DNA helicase activity; helicase activity. There is experimental evidence that it is involved in the biological process</span>: response to DNA damage stimulus; regulation of mitosis; response to UV. 6 alleles are reported. The phenotype of these alleles is annotated with: mitotic cell cycle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Xeroderma pigmentosum D is referred to in FlyBase by the symbol Dmel\Xpd (CG9433, FBgn0015844). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17058460..17062009. It has the cytological map location 57C7. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity; ATP-dependent 5'-3' DNA helicase activity; helicase activity. There is experimental evidence that it is involved in the biological process</span>: response to DNA damage stimulus; regulation of mitosis; response to UV. 6 alleles are reported. The phenotype of these alleles is annotated with: mitotic cell cycle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 745 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    polytene chromosome puff [IDA]
    polytene chromosome interband [IDA]
    cytoplasm [IDA]
    holo TFIIH complex [ISS]
    Biological Process: regulation of mitosis [IMP]
    nucleotide-excision repair [ISS]
    response to UV [IDA]
    response to DNA damage stimulus [IDA]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: ATP binding [IEA]
    DNA binding [IEA]
    ATP-dependent 5'-3' DNA helicase activity [ISS]
    general RNA polymerase II transcription factor activity [ISS]
    helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLELKRSLDA KGHCLLEMPS GTGKTATLLS LIVAYMVEHP ETVRKLIYCS RTVPEIEKVI  60
   61 AELQNLMVYY ERHCPNPPPF TGLVLSSRKN MCIHPEVSKE REGKAVDGKC YGLTASYIRE 120
  121 RHEMDTETPI CQYFEGFSLE GKESTLPVGV YSIDDLKEYG RSRNWCPYFL ARYAIAHAHI 180
  181 VVYSYHYLLD PKIAQVVSKE MSRESCVVFD EAHNIDNVCI DSMSVKINRR TVERSTNALN 240
  241 HLTKLVQDIR EEDTNRLNEE YQRMVQGLKD ASVQRDTDMI LANPVLPNDV LTEVVPGNIR 300
  301 NADHFLSFLR RFIEYIKTRL RVHHVVQESP AGFLKDISSK ICIERKPLRF CAERLSSLLR 360
  361 TLEISDLTEY GALTLITHFA TLVSTYTKGF TIIIEPFDDK TPTVSNPILH FSCLDSSIAM 420
  421 APVFSRFQTV VITSGTLSPM DMYPKILDFD PVVMSSFTMT LARPCLLPMI VSKGNDQVTI 480
  481 SSKFETREDT AVIRNYGQLL VEVAKTVPDG IVCFFTSYLY LESVVASWYD QGIVDTLLRY 540
  541 KLLFIETQDN AETSYALMNY VKACDCGRGA VLLAVARGKV SEGVDFDHHY GRAVLMFGIP 600
  601 YVYTQSRILK ARLDYLRDQF QIRENDFLTF DAMRHAAQCV GRALRGKTDY GIMIFADKRF 660
  661 SRHDKRSRLP KWIQEHLVDS FCNLSTEEAV QLARRWLRRM AQPFTREDQL GISLLTLAQL 720
  721 ENMEQEKLER QAQGKQGVGG EVQEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 9.39794 No description for 2db3A was found.
    2 View Details [214..397] Pfam 114.886057 No description for PF06777.2 was found. No confident structure predictions are available.
    3 View Details [398..745] FFAS03 0.985 No description for 2p6rA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle