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Protein Overview: Rx-PA

General Information:
Name(s) found: Rx-PA / FBpp0071447 [FlyBase]
Description(s) found:
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  • gi|28573580|ref|NP_726006.2| retinal homeobox [Drosophila melanogaster] [NCBI NR]
  • gi|28380638|gb|AAF46639.3| retinal homeobox [Drosophila melanogaster] [NCBI NR]
  • gi|21392130|gb|AAM48419.1| RE39020p [Drosophila melanogaster] [NCBI NR]
  • gi|17380504|sp|Q9W2Q1.2|RX_DROME RecName: Full=Retinal homeobox protein Rx; Short=DRx1; Short=DRx [NCBI NR]
  • Retinal homeobox protein Rx OS=Drosophila melanogaster GN=Rx PE=2 SV=2 [Swiss-Prot]
  • The gene Retinal Homeobox is referred to in FlyBase by the symbol Dmel\Rx (CG10052, FBgn0020617). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16804285..16824537. It has the cytological map location 57B4. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: regulation of transcription from RNA polymerase II promoter. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10052-PA translation from_gene[CG10052 Rx FBgn0020617] seq_release:3 mol_weight=92898 cds_boundaries:(2R:15,960,685..15,980,314[+]) aa_length:873 transcript_info:[CG10052-RA seq_release:3] gene_info:[gene symbol:Rx FBgn0020617 gene_boundaries:(2R:15 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W2Q1) Retinal homeobox protein Rx (DRx1) (DRx) [DrosMelano7227.FASTAC.txt]
  • CG10052-PA [Drosophila melanogaster]gi|21392130|gb|AAM48419.1| RE39020p [Drosophila melanogaster]gi|28573580|ref|NP_726006.2| CG10052-PA [Drosophila melanogaster]gi|17380504|sp|Q9W2Q1|RX_DROME Retinal homeobox protein Rx (DRx1) (DRx) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(16804646..16804922,16805962..16806114,16809964..16811085,16811260..16811426,16823188..16823353,16823542..16824278); ID=FBpp0071447; name=Rx-PA; parent=FBgn0020617,FBtr0071518; dbxref=FlyBase:FBpp0071447,FlyBase_Annotation_IDs:CG1 [fly-100309-contam.fasta]
  • Retinal Homeobox CG10052-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10052-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE39020p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Retinal homeobox protein Rx (DRx1) (DRx) [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(16804646..16804922,16805962..16806114,16809964..16811085,16811260..16811426,16823188..16823353,16823542..16824278); ID=FBpp0071447; name=Rx-PA; parent=FBgn0020617,FBtr0071518; dbxref=FlyBase:FBpp0071447,FlyBase_Annotation_IDs:CG10052-PA,GB_protein:AAF46639.3,REFSEQ:NP_726006,GB_protein:AAF46639; MD5=ec7100fad0aeae5c90a188b256969511; length=873; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(16804646..16804922,16805962..16806114,16809964..16811085,16811260..16811426,16823188..16823353,16823542..16824278); ID=FBpp0071447; name=Rx-PA; parent=FBgn0020617,FBtr0071518; dbxref=FlyBase:FBpp0071447,FlyBase_Annotation_IDs:CG10052-PA,GB_protein:AAF46639.3,REFSEQ:NP_726006,GB_protein:AAF46639; MD5=ec7100fad0aeae5c90a188b256969511; length=873; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:join(16804646..16804922,16805962..16806114,16809964..16811085,16811260..16811426,16823188..16823353,16823542..16824278); ID=FBpp0071447; name=Rx-PA; parent=FBgn0020617,FBtr0071518; dbxref=FlyBase:FBpp0071447,FlyBase_Annotation_IDs:CG10052-PA,GB_protein:AAF46639.3,REFSEQ:NP_726006,GB_protein:AAF46639,FlyMine:FBpp0071447,modMine:FBpp0071447; MD5=ec7100fad0aeae5c90a188b256969511; length=873; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
    • Organism: Drosophila melanogaster
    Length: 873 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: multicellular organismal development [IEA]
    regulation of transcription, DNA-dependent [IEA]
    brain development [NAS]
    regulation of transcription [IEA]
    regulation of transcription from RNA polymerase II promoter [ISS]
    Molecular Function: transcription factor activity [IEA]
    specific RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSGGVANS SSTAAANNTA ATFQHIFEQL VQQGGGNHKL PPKQLEQLRH LLGNVRDAKN  60
   61 LQMIVEKFKN LEQFHEHYAA HLANNNTVIS TEDSNDLVKD NARKYGSGGQ TLTPRHTIDA 120
  121 ILGLKNRNGA ANGSGRNPET VSDGSVDPSL GDDDATDLRC GMTLTQLRSM DNHMASMLQQ 180
  181 HAKNGGALPY GPPTPPGGQQ PQVPNATPLH HGQQMGGQAG HATHAGHGHP THHGHAPFGY 240
  241 HNAFGFGQGG HGYGHPEEAA GNYLNSMHQM VEANQLQTGA NGANPPPAPL PPSSFGSHQQ 300
  301 HLAALAAQAQ EQQNQHSKYA KSSPTGAGPP PPPGAYFMES QTAPVAPSQI NYDERSMSSA 360
  361 SDLEEDDDDA AKLQLDVTSP PTPSPRGQLA AKRKSAGVFC DDNEPKLANG QLPGGNYGIR 420
  421 PRSMEEVHHQ QQSHHHQQQQ QQQQQQQQLQ QQQGFQHDFR NSGNGNPNGN SNSGDHGERL 480
  481 NADSDSLVNG SCASSEDLNQ TNSSEQGEKI TSGSDDEGQD DNCAKKKHRR NRTTFTTYQL 540
  541 HELERAFEKS HYPDVYSREE LAMKVNLPEV RVQVWFQNRR AKWRRQEKSE SLRLGLTHFT 600
  601 QLPHRLGCGA SGLPVDPWLS PPLLSALPGF LSHPQTVYPS YLTPPLSLAP GNLTMSSLAA 660
  661 MGHHHAHNGP PPPHVGHGGH GQPQPPPPPP PHGVPHPHGS HHVVPLSHLS PHLSRMSPHA 720
  721 TSLGSPHHGV TPLGTPLHSS LPPSSTATTV AVSSSQSSSS SASLECSGPD VCMSPQNLSI 780
  781 GNADSNGDGR DLSSDLDAGS TSSNPGSSLD KCAASANIEL LDVGRDSPPP PPTPTGKGSS 840
  841 TPPTDMRSNS IATLRIKAKE HLDNLNKGMV SIV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] deduced N/A No confident structure predictions are available.
    2 View Details [191..362] PSI-BLAST 3.154902 Sec24
    3 View Details [363..497] deduced N/A No confident structure predictions are available.
    4 View Details [498..648] PSI-BLAST 10.154902 Solution structure of the homeobox domain of the human paired box protein Pax-6
    5 View Details [649..729] deduced N/A No confident structure predictions are available.
    6 View Details [730..873] MSA 2.227996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle