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Protein Overview: mus209-PA, mus209-PB

General Information:
Name(s) found: mus209-PB / FBpp0089395 [FlyBase]
mus209-PA / FBpp0085619 [FlyBase]
Description(s) found:
Found 39 descriptions.
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  • The gene mutagen-sensitive 209 is referred to in FlyBase by the symbol Dmel\mus209 (CG9193, FBgn0005655). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16149257..16150362. It has the cytological map location 56F11. There is experimental evidence that it has the molecular function</span>: SUMO binding. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle organization; DNA replication; antimicrobial humoral response. 47 alleles are reported. The phenotypes of these alleles are annotated with: chromosome, centromeric region; ovariole; mitotic cell cycle; ovary; prothoracic leg; follicle cell; spindle; mitotic metaphase. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene mutagen-sensitive 209 is referred to in FlyBase by the symbol Dmel\mus209 (CG9193, FBgn0005655). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16149257..16150362. It has the cytological map location 56F11. There is experimental evidence that it has the molecular function</span>: SUMO binding. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle organization; DNA replication; antimicrobial humoral response. 47 alleles are reported. The phenotypes of these alleles are annotated with: chromosome, centromeric region; ovariole; mitotic cell cycle; ovary; prothoracic leg; follicle cell; spindle; mitotic metaphase. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 260 amino acids

    Gene Ontology:
    Cellular Component: PCNA complex [ISS][NAS]
    Biological Process: eggshell chorion gene amplification [TAS]
    DNA replication [IMP][TAS]
    mitotic spindle organization [IMP]
    DNA-dependent DNA replication [TAS]
    leading strand elongation [NAS]
    nucleotide-excision repair [TAS]
    regulation of DNA replication [IEA]
    mismatch repair [TAS]
    antimicrobial humoral response [IMP]
    Molecular Function: DNA polymerase processivity factor activity [IEA]
    DNA binding [IEA]
    SUMO binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEARLGQAT ILKKILDAIK DLLNEATFDC SDSGIQLQAM DNSHVSLVSL TLRSDGFDKF  60
   61 RCDRNLSMGM NLGSMAKILK CANNEDNVTM KAQDNADTVT IMFESANQEK VSDYEMKLMN 120
  121 LDQEHLGIPE TDFSCVVRMP AMEFARICRD LAQFSESVVI CCTKEGVKFS ASGDVGTANI 180
  181 KLAQTGSVDK EEEAVIIEMQ EPVTLTFACR YLNAFTKATP LSTQVQLSMC ADVPLVVEYA 240
  241 IKDLGHIRYY LAPKIEDNET

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..260] PSI-BLAST 95.69897 Prolifirating cell nuclear antigen (PCNA)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA polymerase processivity factor activity
    		•  9.9878881203193 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  5.01426276108174 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.9656505576274 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  3.23598180825386 bayes_pls_golite062009
  • mismatched DNA binding
    		•  2.75713709757781 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  2.48680473192192 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32553487472442 bayes_pls_golite062009
  • DNA binding
    		•  2.24518789437215 bayes_pls_golite062009
  • binding
    		•  1.88302251910664 bayes_pls_golite062009
  • dinucleotide insertion or deletion binding
    		•  1.68153838099672 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  1.6296761041903 bayes_pls_golite062009
  • MutLalpha complex binding
    		•  1.21442872292245 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.14392061238362 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.785542777582287 bayes_pls_golite062009
  • catalytic activity
    		•  0.48077242755678 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.457118392479642 bayes_pls_golite062009
  • protein binding
    		•  0.452894757163315 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.408841404605319 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.387975438046246 bayes_pls_golite062009
  • transferase activity
    		•  0.345371754708312 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle