YRC Public Data Repository - Protein Structure Prediction

Protein:	mus209-PA, mus209-PB
Organism:	Drosophila melanogaster
Length:	260 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mus209-PA, mus209-PB.

Description	E-value	Query Range	Subject Range
gi\|73991708 - gi\|73991708\|ref\|XP_534355.2\| PREDICTED: similar to proliferating cell nuclear antigen [Canis familia...	372.0	[0..1]	[259..206]
gi\|53600 - gi\|53600\|emb\|CAA37243.1\| unnamed protein product [Mus musculus]	350.0	[0..1]	[260..1]
PCNA_BOVIN - Proliferating cell nuclear antigen OS=Bos taurus GN=PCNA PE=2 SV=1	347.0	[0..1]	[259..1]
PCNA_RAT - Proliferating cell nuclear antigen OS=Rattus norvegicus GN=Pcna PE=1 SV=1	347.0	[0..1]	[259..1]
gi\|55651058, gi\|... - gi\|55651058\|ref\|XP_514499.1\| PREDICTED: proliferating cell nuclear antigen isoform 2 [Pan troglodyte... PCNA_MACFA - Proliferating cell nuclear antigen OS=Macaca fascicularis GN=PCNA PE=2 SV=1 gi\|109092793, gi... - gi\|109092795\|ref\|XP_001115756.1\| PREDICTED: proliferating cell nuclear antigen isoform 2 [Macaca mul... ENSCJAT00000041839 - null gi\|208967140, gi... - gi\|61359492\|gb\|AAX41726.1\| proliferating cell nuclear antigen [synthetic construct], gi\|61358193\|gb\|... PCNA - proliferating cell nuclear antigen HGNC:8729\|MIM:17... - cell nuclear antigen	347.0	[0..1]	[259..1]
gi\|61368335, gi\|... - gi\|61369547\|gb\|AAX43349.1\| proliferating cell nuclear antigen [synthetic construct], gi\|61368335\|gb\|...	347.0	[0..1]	[259..1]
PCNA_CHICK - Proliferating cell nuclear antigen OS=Gallus gallus GN=PCNA PE=1 SV=1	346.0	[0..1]	[257..1]

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Predicted Domain #1

Region A:
Residues: [1-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEARLGQAT ILKKILDAIK DLLNEATFDC SDSGIQLQAM DNSHVSLVSL TLRSDGFDKF  60
   61 RCDRNLSMGM NLGSMAKILK CANNEDNVTM KAQDNADTVT IMFESANQEK VSDYEMKLMN 120
  121 LDQEHLGIPE TDFSCVVRMP AMEFARICRD LAQFSESVVI CCTKEGVKFS ASGDVGTANI 180
  181 KLAQTGSVDK EEEAVIIEMQ EPVTLTFACR YLNAFTKATP LSTQVQLSMC ADVPLVVEYA 240
  241 IKDLGHIRYY LAPKIEDNET

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	95.69897
Match:	1axcA
Description:	Prolifirating cell nuclear antigen (PCNA)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA polymerase processivity factor activity	9.9878881203193	bayes_pls_golite062009
DNA-directed DNA polymerase activity	5.01426276108174	bayes_pls_golite062009
DNA polymerase activity	4.9656505576274	bayes_pls_golite062009
nucleotidyltransferase activity	3.23598180825386	bayes_pls_golite062009
mismatched DNA binding	2.75713709757781	bayes_pls_golite062009
DNA insertion or deletion binding	2.48680473192192	bayes_pls_golite062009
nucleic acid binding	2.32553487472442	bayes_pls_golite062009
DNA binding	2.24518789437215	bayes_pls_golite062009
binding	1.88302251910664	bayes_pls_golite062009
dinucleotide insertion or deletion binding	1.68153838099672	bayes_pls_golite062009
mismatch repair complex binding	1.6296761041903	bayes_pls_golite062009
MutLalpha complex binding	1.21442872292245	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.14392061238362	bayes_pls_golite062009
structure-specific DNA binding	0.785542777582287	bayes_pls_golite062009
catalytic activity	0.48077242755678	bayes_pls_golite062009
double-stranded DNA binding	0.457118392479642	bayes_pls_golite062009
protein binding	0.452894757163315	bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity	0.408841404605319	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	0.387975438046246	bayes_pls_golite062009
transferase activity	0.345371754708312	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: