Protein Overview: CalpA-PC, CalpA-PB

General Information:
Name(s) found:	CalpA-PC / FBpp0111782 [FlyBase] CalpA-PB / FBpp0085714 [FlyBase]
Description(s) found: Found 34 descriptions. SHOW ALL	The gene Calpain-A is referred to in FlyBase by the symbol Dmel\CalpA (CG7563, FBgn0012051). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15312578..15318068. It has the cytological map location 56D5. It is reported to have molecular function</span>: calcium-dependent cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: phagocytosis, engulfment. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene Calpain-A is referred to in FlyBase by the symbol Dmel\CalpA (CG7563, FBgn0012051). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15312578..15318068. It has the cytological map location 56D5. It is reported to have molecular function</span>: calcium-dependent cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: phagocytosis, engulfment. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	828 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [NAS] intracellular [IEA]
Biological Process:	phagocytosis, engulfment [IMP] proteolysis [IEA] protein autoprocessing [TAS] actin cytoskeleton organization [NAS]
Molecular Function:	calcium ion binding [IEA] calcium-dependent cysteine-type endopeptidase activity [IEA][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDLRGFLRQ AGQEFLNAAG EAAMGAAKDV VGSVINEIFI KKEADTKRVL PSIKNMRVLG  60
   61 EKSSSLGPYS EVQDYETILN SCLASGSLFE DPLFPASNES LQFSRRPDRH IEWLRPHEIA 120
  121 ENPQFFVEGY SRFDVQQGEL GDCWLLAATA NLTQESNLFF RVIPAEQSFE ENYAGIFHFR 180
  181 FWQYGKWVDV IIDDRLPTYN GELMYMHSTE KNEFWSALLE KAYAKLHGSY EALKGGSTCE 240
  241 AMEDFTGGVS EWYDLKEAPG NLFTILQKAA ERNSMMGCSI EPDPNVTEAE TPQGLIRGHA 300
  301 YSITKVCLID IVTPNRQGKI PMIRMRNPWG NEAEWNGPWS DSSPEWRYIP EEQKAEIGLT 360
  361 FDRDGEFWMS FQDFLNHFDR VEICNLSPDS LTEDQQNSGK RKWEMSMYEG EWTPGVTAGG 420
  421 CRNFLDTFWH NPQYIITLVD PDEEDEEGQC TVIVALMQKN RRSKRNMGME CLTIGFAIYS 480
  481 LNDRELENRP QGLNFFRYKS SVGRSPHFIN TREVCARFKL PPGHYLIVPS TFDPNEEGEF 540
  541 IIRVFSETQN NMEENDDHVG YGGKADTITP GFPTPKPIDP QKEGLRRLFD SIAGKDMEVD 600
  601 WMELKRILDH SMRDDLPKPV VFNRFSNNMA FETQAAGPGD DGAGACGLLS LICGPFLKGT 660
  661 PFEEQLGMND QSNKRLIGDN PADGGPVTAN AIVDETHGFS KDVCRSMVAM LDADKSGKLG 720
  721 FEEFETLLSE IAKWKAIFKV YDVENTGRVS GFQLREALNS AGYHLNNRVL NVLGHRYGSR 780
  781 DGKIAFDDFI MCAVKIKTYI DIFKERDTEK NETATFTLEE WIERTIYS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
calcium ion binding	3.79609619542776	bayes_pls_golite062009
binding	3.17556402087346	bayes_pls_golite062009
protein binding	2.21291432166051	bayes_pls_golite062009
cytoskeletal protein binding	1.6550001867465	bayes_pls_golite062009
ion binding	1.36376383271837	bayes_pls_golite062009
metal ion binding	1.34827363853601	bayes_pls_golite062009
cation binding	1.34827363853601	bayes_pls_golite062009
structural constituent of muscle	1.30577051923353	bayes_pls_golite062009
actin binding	1.1967948958876	bayes_pls_golite062009
transporter activity	1.15928534291452	bayes_pls_golite062009
small conjugating protein-specific protease activity	1.07520173658976	bayes_pls_golite062009
transmembrane transporter activity	0.945691505472547	bayes_pls_golite062009
molecular transducer activity	0.933783050059916	bayes_pls_golite062009
signal transducer activity	0.933783050059916	bayes_pls_golite062009
transcription regulator activity	0.751129118065137	bayes_pls_golite062009
nucleic acid binding	0.735175568865652	bayes_pls_golite062009
motor activity	0.68020805045422	bayes_pls_golite062009
microfilament motor activity	0.515693296786409	bayes_pls_golite062009
ubiquitin-specific protease activity	0.495368836247989	bayes_pls_golite062009
substrate-specific transporter activity	0.438908712437433	bayes_pls_golite062009
DNA binding	0.35088910990002	bayes_pls_golite062009
active transmembrane transporter activity	0.246383459363256	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.20908131617536	bayes_pls_golite062009
calcium-dependent protein binding	0.170792976663713	bayes_pls_golite062009
protein complex binding	0.0676093357928913	bayes_pls_golite062009
hydrolase activity	0.0468413224205481	bayes_pls_golite062009
transcription factor activity	0.00805573746748856	bayes_pls_golite062009
endopeptidase activity	1.34146644313882E-4	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..828]	PSI-BLAST	173.0	Crystal Structure of a mu-like calpain

Protein Overview: CalpA-PC, CalpA-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: