Protein Overview: stau-PA

General Information:
Name(s) found:	stau-PA / FBpp0085962 [FlyBase]
Description(s) found: Found 21 descriptions. SHOW ALL	The gene staufen is referred to in FlyBase by the symbol Dmel\stau (CG5753, FBgn0003520). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14005401..14013337. It has the cytological map location 55B5-55B7. There is experimental evidence that it has the molecular function</span>: mRNA 3'-UTR binding. There is experimental evidence that it is involved in the biological process</span>: RNA localization; positive regulation of cytoplasmic mRNA processing body assembly; pole plasm protein localization; regulation of pole plasm oskar mRNA localization; long-term memory; pole plasm assembly; determination of anterior/posterior axis, embryo; pole plasm RNA localization. 29 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: embryonic abdomen; embryonic segment; embryonic tagma; anatomical structure; embryonic head; abdominal segment 7; blastoderm embryo; cell part; embryonic abdominal segment 4; extended germ band embryo; abdominal segment 10; intracellular. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1026 amino acids
Gene Ontology:
Cellular Component:	apical part of cell [IDA] cytoplasm [IDA] cell cortex [IDA] cytoplasmic mRNA processing body [IDA] apical cortex [IDA] basal cortex [IDA][NAS][TAS] microtubule associated complex [ISS]
Biological Process:	intracellular mRNA localization [NAS][TAS] anterior/posterior axis specification, embryo [IGI] protein localization [TAS] neuroblast fate determination [TAS] pole plasm assembly [IMP][NAS] pole plasm RNA localization [IMP] RNA localization [IMP] microtubule-based process [ISS] pole plasm mRNA localization [TAS] long-term memory [IMP][TAS] regulation of pole plasm oskar mRNA localization [IGI][TAS] pole plasm protein localization [IMP][TAS] oogenesis [TAS] asymmetric protein localization involved in cell fate determination [TAS] bicoid mRNA localization [NAS][TAS] regulation of oskar mRNA translation [TAS] positive regulation of cytoplasmic mRNA processing body assembly [IMP] pole plasm oskar mRNA localization [TAS] positive regulation of oskar mRNA translation [NAS] asymmetric neuroblast division [NAS]
Molecular Function:	double-stranded RNA binding [IEA][ISS][TAS] mRNA binding [NAS] mRNA 3'-UTR binding [IDA] microtubule binding [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQHNVHAARP APHIRAAHHH SHSHAHMHLH PGMEQHLGPS LQQQQQPPPP PQQPPHRDLH  60
   61 ARLNHHHLHA QQQQQQQTSS NQAGAVAAAG AAYHHGNINS NSGSNISSNS NQMQKIRQQH 120
  121 QHLSSSNGLL GNQPPGPPPQ AFNPLAGNPA ALAYNQLPPH PPHHMAAHLG SYAAPPPHYY 180
  181 MSQAKPAKYN HYGSNANSNS GSNNSNSNYA PKAILQNTYR NQKVVVPPVV QEVTPVPEPP 240
  241 VTTNNATTNS TSNSTVIASE PVTQEDTSQK PETRQEPASA DDHVSTGNID ATGALSNEDT 300
  301 SSSGRGGKDK TPMCLVNELA RYNKITHQYR LTEERGPAHC KTFTVTLMLG DEEYSADGFK 360
  361 IKKAQHLAAS KAIEETMYKH PPPKIRRSEE GGPMRTHITP TVELNALAMK LGQRTFYLLD 420
  421 PTQIPPTDSI VPPEFAGGHL LTAPGPGMPQ PPPPPAYALR QRLGNGFVPI PSQPMHPHFF 480
  481 HGPGQRPFPP KFPSRFALPP PLGAHVHHGP NGPFPSVPTP PSKITLFVGK QKFVGIGRTL 540
  541 QQAKHDAAAR ALQVLKTQAI SASEEALEDS MDEGDKKSPI SQVHEIGIKR NMTVHFKVLR 600
  601 EEGPAHMKNF ITACIVGSIV TEGEGNGKKV SKKRAAEKML VELQKLPPLT PTKQTPLKRI 660
  661 KVKTPGKSGA AAREGSVVSG TDGPTQTGKP ERRKRLNPPK DKLIDMDDAD NPITKLIQLQ 720
  721 QTRKEKEPIF ELIAKNGNET ARRREFVMEV SASGSTARGT GNSKKLAKRN AAQALFELLE 780
  781 AVQVTPTNET QSSEECSTSA TMSAVTAPAV EATAEGKVPM VATPVGPMPG ILILRQNKKP 840
  841 AKKRDQIVIV KSNVESKEEE ANKEVAVAAE ENSNNSANSG DSSNSSSGDS QATEAASESA 900
  901 LNTSTGSNTS GVSSNSSNVG ANTDGNNHAE SKNNTESSSN STSNTQSAGV HMKEQLLYLS 960
  961 KLLDFEVNFS DYPKGNHNEF LTIVTLSTHP PQICHGVGKS SEESQNDAAS NALKILSKLG1020
 1021 LNNAMK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..228]	PSI-BLAST	7.09691	Sec24
2	View Details	[229..305]	deduced	N/A	No confident structure predictions are available.
3	View Details	[306..419]	PSI-BLAST	11.09691	Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase
4	View Details	[420..482]	deduced	N/A	No confident structure predictions are available.
5	View Details	[483..557]	PSI-BLAST	27.522879	RNase III endonuclease catalytic domain; RNase III, C-terminal domain
6	View Details	[558..647]	PSI-BLAST	17.522879	Staufen, domain III
7	View Details	[648..804]	PSI-BLAST	6.0	Solution structure of the dsRBD from hypothetical protein BAB26260
8	View Details	[805..1026]	FFAS03	3.24	dsRNA-dependent protein kinase pkr

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

Term	Confidence	Notes
nucleic acid binding	2.98844454241303	bayes_pls_golite062009
binding	2.86619976447436	bayes_pls_golite062009
structural constituent of ribosome	2.82435487029184	bayes_pls_golite062009
structural molecule activity	2.66201477910663	bayes_pls_golite062009
tubulin binding	2.64441327259575	bayes_pls_golite062009
microtubule binding	2.56910114599273	bayes_pls_golite062009
protein binding	2.48364477869915	bayes_pls_golite062009
RNA binding	1.95224155318843	bayes_pls_golite062009
DNA binding	1.49492945560218	bayes_pls_golite062009
transcription regulator activity	1.22178500811874	bayes_pls_golite062009
double-stranded RNA binding	0.967560318725736	bayes_pls_golite062009
cytoskeletal protein binding	0.935558208370217	bayes_pls_golite062009
transcription activator activity	0.880231812214114	bayes_pls_golite062009
transcription factor activity	0.31021399747574	bayes_pls_golite062009

4

No functions predicted.

5

No functions predicted.

6

Term	Confidence	Notes
nucleic acid binding	2.98844454241303	bayes_pls_golite062009
binding	2.86619976447436	bayes_pls_golite062009
structural constituent of ribosome	2.82435487029184	bayes_pls_golite062009
structural molecule activity	2.66201477910663	bayes_pls_golite062009
tubulin binding	2.64441327259575	bayes_pls_golite062009
microtubule binding	2.56910114599273	bayes_pls_golite062009
protein binding	2.48364477869915	bayes_pls_golite062009
RNA binding	1.95224155318843	bayes_pls_golite062009
DNA binding	1.49492945560218	bayes_pls_golite062009
transcription regulator activity	1.22178500811874	bayes_pls_golite062009
double-stranded RNA binding	0.967560318725736	bayes_pls_golite062009
cytoskeletal protein binding	0.935558208370217	bayes_pls_golite062009
transcription activator activity	0.880231812214114	bayes_pls_golite062009
transcription factor activity	0.31021399747574	bayes_pls_golite062009

7

Term	Confidence	Notes
nucleic acid binding	2.98844454241303	bayes_pls_golite062009
binding	2.86619976447436	bayes_pls_golite062009
structural constituent of ribosome	2.82435487029184	bayes_pls_golite062009
structural molecule activity	2.66201477910663	bayes_pls_golite062009
tubulin binding	2.64441327259575	bayes_pls_golite062009
microtubule binding	2.56910114599273	bayes_pls_golite062009
protein binding	2.48364477869915	bayes_pls_golite062009
RNA binding	1.95224155318843	bayes_pls_golite062009
DNA binding	1.49492945560218	bayes_pls_golite062009
transcription regulator activity	1.22178500811874	bayes_pls_golite062009
double-stranded RNA binding	0.967560318725736	bayes_pls_golite062009
cytoskeletal protein binding	0.935558208370217	bayes_pls_golite062009
transcription activator activity	0.880231812214114	bayes_pls_golite062009
transcription factor activity	0.31021399747574	bayes_pls_golite062009

8

Term	Confidence	Notes
nucleic acid binding	2.80632915073735	bayes_pls_golite062009
binding	2.73737762243378	bayes_pls_golite062009
structural constituent of ribosome	2.69938614227852	bayes_pls_golite062009
tubulin binding	2.59197201719144	bayes_pls_golite062009
structural molecule activity	2.56149875079819	bayes_pls_golite062009
microtubule binding	2.50694560502594	bayes_pls_golite062009
protein binding	2.38844215549064	bayes_pls_golite062009
RNA binding	1.63984513781471	bayes_pls_golite062009
DNA binding	1.44777714653394	bayes_pls_golite062009
transcription regulator activity	1.22603137650888	bayes_pls_golite062009
cytoskeletal protein binding	0.927228352447363	bayes_pls_golite062009
transcription activator activity	0.834760842898207	bayes_pls_golite062009
double-stranded RNA binding	0.402046758389082	bayes_pls_golite062009
transcription factor activity	0.312418023287799	bayes_pls_golite062009
catalytic activity	0.00430305721638241	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle