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Protein Overview: proPO-A1-PA

General Information:
Name(s) found: proPO-A1-PA / FBpp0291497 [FlyBase]
Description(s) found:
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  • gi|7302696|gb|AAF57775.1| black cells [Drosophila melanogaster] [NCBI NR]
  • gi|17136630|ref|NP_476812.1| black cells [Drosophila melanogaster] [NCBI NR]
  • gi|16767894|gb|AAL28165.1| GH04080p [Drosophila melanogaster] [NCBI NR]
  • The gene prophenol oxidase A1 is referred to in FlyBase by the symbol Dmel\proPO-A1 (CG42639, FBgn0261362). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13774718..13777477. It has the cytological map location 54F6. There is experimental evidence that it has the molecular function</span>: catechol oxidase activity; monophenol monooxygenase activity. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG5779-PA translation from_gene[CG5779 Bc FBgn0000165] seq_release:3 mol_weight=79092 cds_boundaries:(2R:12,951,140..12,953,625[-]) aa_length:690 transcript_info:[CG5779-RA seq_release:3] gene_info:[gene symbol:Bc FBgn0000165 gene_boundaries:(2R:12,95 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V896) BC gene product (GH04080P) [DrosMelano7227.FASTAC.txt]
  • (AE003801) Bc gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5779-PA [Drosophila melanogaster]gi|16767894|gb|AAL28165.1| GH04080p [Drosophila melanogaster]gi|17136630|ref|NP_476812.1| CG5779-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(13774917..13775115,13775175..13775427,13775585..13776218,13776293..13776787,13776857..13776992,13777050..13777405); ID=FBpp0085998; name=Bc-PA; parent=FBgn0000165,FBtr0086819; dbxref=FlyBase:FBpp0085998,FlyBase_Annotation_I [fly-100309-contam.fasta]
  • Black cells CG5779-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG5779-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • GH04080p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(13774917..13775115,13775175..13775427,13775585..13776218,13776293..13776787,13776857..13776992,13777050..13777405); ID=FBpp0085998; name=Bc-PA; parent=FBgn0000165,FBtr0086819; dbxref=FlyBase:FBpp0085998,FlyBase_Annotation_IDs:CG5779-PA,GB_protein:AAF57775.1,REFSEQ:NP_476812,GB_protein:AAF57775; MD5=bbf9b7e4c8018e0f585820765dc86c71; length=690; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(13774917..13775115,13775175..13775427,13775585..13776218,13776293..13776787,13776857..13776992,13777050..13777405); ID=FBpp0085998; name=Bc-PA; parent=FBgn0000165,FBtr0086819; dbxref=FlyBase:FBpp0085998,FlyBase_Annotation_IDs:CG5779-PA,GB_protein:AAF57775.1,REFSEQ:NP_476812,GB_protein:AAF57775; MD5=bbf9b7e4c8018e0f585820765dc86c71; length=690; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • GH04080p OS=Drosophila melanogaster GN=proPO-A1 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(13774917..13775115,13775175..13775427,13775585..13776218,13776293..13776787,13776857..13776992,13777050..13777405); ID=FBpp0291497; name=proPO-A1-PA; parent=FBgn0261362,FBtr0302291; dbxref=REFSEQ:NP_476812,GB_protein:AAF57775,FlyBase_Annotation_IDs:CG42639-PA,FlyBase:FBpp0291497,FlyBase:FBpp0085998,FlyBase_Annotation_IDs:CG5779-PA,FlyMine:FBpp0291497,modMine:FBpp0291497; MD5=bbf9b7e4c8018e0f585820765dc86c71; length=690; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(17889545..17889900,17889352..17889487,17888788..17889282,17888080..17888713,17887670..17887922,17887412..17887610)); ID=FBpp0291497; name=PPO1-PA; parent=FBgn0261362,FBtr0302291; dbxref=REFSEQ:NP_476812,GB_protein:AAF57775,FlyBase_Annotation_IDs:CG42639-PA,FlyBase:FBpp0291497,FlyBase:FBpp0085998,FlyBase_Annotation_IDs:CG5779-PA,FlyMine:FBpp0291497,modMine:FBpp0291497; MD5=bbf9b7e4c8018e0f585820765dc86c71; length=690; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(17889545..17889900,17889352..17889487,17888788..17889282,17888080..17888713,17887670..17887922,17887412..17887610)); ID=FBpp0291497; name=PPO1-PA; parent=FBgn0283437,FBtr0302291; dbxref=REFSEQ:NP_476812,GB_protein:AAF57775,FlyBase_Annotation_IDs:CG42639-PA,FlyBase:FBpp0291497,FlyBase:FBpp0085998,FlyBase_Annotation_IDs:CG5779-PA,FlyMine:FBpp0291497,modMine:FBpp0291497; MD5=bbf9b7e4c8018e0f585820765dc86c71; length=690; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • GH04080p OS=Drosophila melanogaster GN=PPO1 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0291497 type=protein; loc=2R:complement(join(17889545..17889900,17889352..17889487,17888788..17889282,17888080..17888713,17887670..17887922,17887412..17887610)); ID=FBpp0291497; name=PPO1-PA; parent=FBgn0283437,FBtr0302291; dbxref=REFSEQ:NP_476812,GB_protein:AAF57775,FlyBase_Annotation_IDs:CG42639-PA,FlyBase:FBpp0291497,FlyBase:FBpp0085998,FlyBase_Annotation_IDs:CG5779-PA,FlyMine:FBpp0291497,modMine:FBpp0291497; MD5=bbf9b7e4c8018e0f585820765dc86c71; length=690; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(17889545..17889900,17889352..17889487,17888788..17889282,17888080..17888713,17887670..17887922,17887412..17887610)); ID=FBpp0291497; name=PPO1-PA; parent=FBgn0283437,FBtr0302291; dbxref=REFSEQ:NP_476812,GB_protein:AAF57775,FlyBase_Annotation_IDs:CG42639-PA,FlyBase:FBpp0291497,FlyBase:FBpp0085998,FlyBase_Annotation_IDs:CG5779-PA,UniProt/TrEMBL:Q7K2W6,FlyMine:FBpp0291497,modMine:FBpp0291497; MD5=bbf9b7e4c8018e0f585820765dc86c71; length=690; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 690 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: monophenol monooxygenase activity [IDA]
    catechol oxidase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNTDLKALE LMFQRPLEPA FTTRDSGKTV LELPDSFYTD RYRNDTEEVG NRFSKDVDLK  60
   61 IPIQELSNVP SLEFTKKIGL KNQFSLFNNR HREIASELIT LFMSAPNLRQ FVSLSVYTKD 120
  121 RVNPVLFQYA YAVAVAHRPD TREVPITNIS QIFPSNFVEP SAFRDARQEA SVIGESGARV 180
  181 HVDIPQNYTA SDREDEQRLA YFREDIGVNS HHWHWHLVYP TTGPTEVVNK DRRGELFYYM 240
  241 HHQILARYNV ERFCNNLKKV QPLNNLRVEV PEGYFPKILS STNNRTYPAR VTNQKLRDVD 300
  301 RHDGRVEISD VERWRDRVLA AIDQGYVEDS SGNRIPLDEV RGIDILGNMI EASPVLSINY 360
  361 NFYGNLHNEG HNIISFAHDP DYRHLEEFGV MGDVTTAMRD PIFYRWHGFI DTVFNKFKTR 420
  421 LNPYNAGELN FDGITVDYIE AKIGKSNTKA NTLLTYWQKS SADLAAGLDF GPTTDRNIFA 480
  481 SFTHLQNAPF TYTFNVTNNG ARRTGTCRIF ICPKVDERNQ ALNLEEQRLL AIEMDKFTVD 540
  541 LVPGENTIRR QSTESSVAIP FERSFRPVGA DYQPKAADEL ARFKFCGCGW PQHLLLPKGN 600
  601 AQGMVFDLFV MISDYSQDSV EQPKTPNDAC STAYSFCGLK DKLYPDRRTM GYPFDRRLPN 660
  661 ANLTELVGAF GNMAKTDLRI VFNDRVIDKA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..690] PSI-BLAST 1000.0 CRYSTAL STRUCTURE OF DEOXYGENATED LIMULUS POLYPHEMUS SUBUNIT II HEMOCYANIN AT 2.18 ANGSTROMS RESOLUTION: CLUES FOR A MECHANISM FOR ALLOSTERIC REGULATION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • monophenol monooxygenase activity
    		•  6.32591865272965 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
    		•  6.32591865272965 bayes_pls_golite062009
  • nutrient reservoir activity
    		•  4.66711608375151 bayes_pls_golite062009
  • copper ion binding
    		•  4.17531304229298 bayes_pls_golite062009
  • oxygen transporter activity
    		•  3.17372037178661 bayes_pls_golite062009
  • protein binding
    		•  2.55331587515144 bayes_pls_golite062009
  • binding
    		•  2.01555579124143 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.94268098951022 bayes_pls_golite062009
  • transporter activity
    		•  1.94143938635343 bayes_pls_golite062009
  • cation channel activity
    		•  1.84843298243351 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  1.82318341284761 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  1.81839281588293 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  1.81742923395177 bayes_pls_golite062009
  • potassium channel activity
    		•  1.81257297770622 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.81071289575882 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.76281327097473 bayes_pls_golite062009
  • ion channel activity
    		•  1.70663166559662 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.70274134661261 bayes_pls_golite062009
  • gated channel activity
    		•  1.68818168029572 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.66007375521419 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.65899897018442 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.65208263051952 bayes_pls_golite062009
  • channel activity
    		•  1.63616928632474 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.63616928632474 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.52401313013637 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.32367033892557 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.32367033892557 bayes_pls_golite062009
  • receptor binding
    		•  1.09304823464456 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.66833829018424 bayes_pls_golite062009
  • chloride ion binding
    		•  0.661660419769762 bayes_pls_golite062009
  • anion binding
    		•  0.556715919370575 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  0.452212764829856 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  0.43450134854604 bayes_pls_golite062009
  • pattern binding
    		•  0.43058080093593 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.0955736390419211 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0605091734844516 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle