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Protein Overview: FBpp0305371, lack-PA

General Information:
Name(s) found: FBpp0305371 [FlyBase]
lack-PA / FBpp0086011 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • type=protein; loc=2R:join(13481355..13481409,13481471..13481509,13487355..13487591,13487647..13489852,13489909..13490108,13490168..13490331,13490407..13490691); ID=FBpp0305371; name=lack-PB; parent=FBgn0029006,FBtr0333168; dbxref=REFSEQ:NP_001261061,GB_protein:AGB93593,FlyBase:FBpp0305371,FlyBase_Annotation_IDs:CG4943-PB; MD5=5c8a3c809465af85d8534d114f131b5e; length=1061; release=r5.56; species=Dmel; [FlyBase]
  • The gene lethal with a checkpoint kinase is referred to in FlyBase by the symbol Dmel\lack (CG4943, FBgn0029006). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13480319..13491489. It has the cytological map location 54C12-54D1. There is experimental evidence that it has the molecular function</span>: protein binding; specific transcriptional repressor activity. There is experimental evidence that it is involved in the biological process</span>: decapentaplegic receptor signaling pathway; transforming growth factor beta receptor signaling pathway; embryonic hindgut morphogenesis; embryonic development via the syncytial blastoderm; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of growth. 10 alleles are reported. The phenotypes of these alleles are annotated with: leg; wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1061 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: embryonic hindgut morphogenesis [IMP]
    embryonic development via the syncytial blastoderm [IMP]
    transforming growth factor beta receptor signaling pathway [IGI]
    decapentaplegic receptor signaling pathway [IMP]
    regulation of growth [IGI][IMP]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [IMP]
    Molecular Function: ubiquitin-protein ligase activity [ISS][NAS]
    protein binding [IPI]
    specific transcriptional repressor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKLDYPRRN GTHKVRITIL CARNLARKDL FRLPDPFAKV QVDGTGQVYS TEISKSSLDP  60
   61 KWNAHYDLFL GIGDAITITV WNQRKIHKGS GFLGCVRIPA FNIQSLKGAG FQRLDLGKLS 120
  121 PDDDELVRGQ IIISLLSKDG PSSGNPLAIV GPSGDVRGPS EDDSSEDSLP EGWEERRTDN 180
  181 GRVYYVNHAT KSTQWDRPRQ PGVVGSSHAT SPQQRHNTHN GNSGDRQAPA GPTRSTTCTN 240
  241 LMNNGHRSRD LSVTASDERR HSTEILSSVG KENTSPTTPV SATTTPGKKT SSSNSSSAGG 300
  301 RTLEQRPTNE PATPTSSTTS ASVRLHSNDN HVKTPKHQTN GHAPPESTPT SPTGQQNYVN 360
  361 GNAQNGSTSG NGSGQAAQPQ SASNGWTQED AATTTSPSTT TSPPRHSQSP PTPNISPPAS 420
  421 VTPSANGNVH SPNANSTPAG SGGGSRSYTA ATPGQRSQRR SSRQQGEESS TRRRSSRGTR 480
  481 NGGTSGGGGG GGSGQRYASA AIAAANQAAR PFLDLPPGYE MRTTQQGQVY FYHIPTGVST 540
  541 WHDPRIPRDF DTQHLTLDAI GPLPSGWEQR KTASGRVYFV DHNNRTTQFT DPRLSGSILQ 600
  601 MIRRGTVPPT SAANAGTPAP PSATPATPSA AAAVPPQATP ASNATPTTLT TTTNPPHRIV 660
  661 PDLPQGLLEG ADLLPKYRRD LVGKLRALRT ELQTMQPQSG HCRLEVSRNE IFEESYRLIM 720
  721 KMRAKDMRKR LMVKFKGEEG LDYGGVAREW LHLLSREMLN PQYGLFQYSR DDHYTLQINP 780
  781 DSGVNPDHLS YFHFVGRTLG IAVFHGHCLD GGFTTPFYKQ LLNKPITLGD IEGVDPDLHR 840
  841 SLTWMLESNI SGIIESTFSV ENNSFGALVV HELKPGGASI PVTEENKREY VKLYVNYRFM 900
  901 RGIEQQFLAL QKGFCELIPS HLLRPFDERE LELVIGGISS IDVNDWRNNT RLKHCTNETT 960
  961 QVLWFWQVVE SYSSEMRARL LQFVTGSSRV PLQGFRALQG STGAVGPRLF TIHLTADVPT1020
 1021 QNLPKAHTCF NRIDLPPYET YQLLCDKLTQ AVEETCGFAV E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] PSI-BLAST 28.69897 No description for 2jqzA was found.
    2 View Details [185..392] deduced N/A No confident structure predictions are available.
    3 View Details [393..493] deduced N/A No confident structure predictions are available.
    4 View Details [494..653] PSI-BLAST 3.69897 NMR structure of WW domains (WW3-4) from Suppressor of Deltex
    5 View Details [654..1061] PSI-BLAST 132.0 Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • proline-rich region binding
    		•  2.77294348104858 bayes_pls_golite062009
  • binding
    		•  2.62219069341981 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.59532734096591 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.41863405676058 bayes_pls_golite062009
  • transcription factor binding
    		•  1.96854466908038 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.90194027965368 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.6967322982151 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.48697365532578 bayes_pls_golite062009
  • protein binding
    		•  1.46903005775608 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19192967543742 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.121001087082 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.10202813119932 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.04492347407385 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.568363753662296 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.2295693429366 bayes_pls_golite062009
  • catalytic activity
    		•  0.210712504691113 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K36 specific)
    		•  0.173723075520888 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle