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Protein Overview: Sply-PA, Sply-PB

General Information:
Name(s) found: Sply-PB / FBpp0086159 [FlyBase]
Sply-PA / FBpp0086158 [FlyBase]
Description(s) found:
Found 39 descriptions.
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  • The gene Sphingosine-1-phosphate lyase is referred to in FlyBase by the symbol Dmel\Sply (CG8946, FBgn0010591). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12975939..12979462. It has the cytological map location 53F6-53F7. There is experimental evidence that it has the molecular function</span>: sphinganine-1-phosphate aldolase activity. There is experimental evidence that it is involved in the biological process</span>: sphingolipid catabolic process. 6 alleles are reported. The phenotype of these alleles is annotated with: dorsal medial muscle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Sphingosine-1-phosphate lyase is referred to in FlyBase by the symbol Dmel\Sply (CG8946, FBgn0010591). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12975939..12979462. It has the cytological map location 53F6-53F7. There is experimental evidence that it has the molecular function</span>: sphinganine-1-phosphate aldolase activity. There is experimental evidence that it is involved in the biological process</span>: sphingolipid catabolic process. 6 alleles are reported. The phenotype of these alleles is annotated with: dorsal medial muscle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 545 amino acids

    Gene Ontology:
    Cellular Component: integral to endoplasmic reticulum membrane [NAS]
    Biological Process: carboxylic acid metabolic process [IEA]
    sphingolipid catabolic process [IMP][NAS]
    Molecular Function: pyridoxal phosphate binding [IEA]
    sphinganine-1-phosphate aldolase activity [IDA][NAS]
    carboxy-lyase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPFSGSDCL KPVTEGINRA FGAKEPWQVA TITATTVLGG VWLWTVICQD ENLYIRGKRQ  60
   61 FFKFAKKIPA VRRQVETELA KAKNDFETEI KKSNAHLTYS ETLPEKGLSK EEILRLVDEH 120
  121 LKTGHYNWRD GRVSGAVYGY KPDLVELVTE VYGKASYTNP LHADLFPGVC KMEAEVVRMA 180
  181 CNLFHGNSAS CGTMTTGGTE SIVMAMKAYR DFAREYKGIT RPNIVVPKTV HAAFDKGGQY 240
  241 FNIHVRSVDV DPETYEVDIK KFKRAINRNT ILLVGSAPNF PYGTIDDIEA IAALGVKYDI 300
  301 PVHVDACLGS FVVALVRNAG YKLRPFDFEV KGVTSISADT HKYGFAPKGS SVILYSDKKY 360
  361 KDHQFTVTTD WPGGVYGSPT VNGSRAGGII AACWATMMSF GYDGYLEATK RIVDTARYIE 420
  421 RGVRDIDGIF IFGKPATSVI ALGSNVFDIF RLSDSLCKLG WNLNALQFPS GIHLCVTDMH 480
  481 TQPGVADKFI ADVRSCTAEI MKDPGQPVVG KMALYGMAQS IPDRSVIGEV TRLFLHSMYY 540
  541 TPSQK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..545] PSI-BLAST 47.39794 Crystal structure of the complex of Escherichia coli GADA with glutarate at 2.05 A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • serine C-palmitoyltransferase activity
    		•  4.27273846204139 bayes_pls_golite062009
  • C-palmitoyltransferase activity
    		•  4.27273846204139 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.18577404365776 bayes_pls_golite062009
  • transaminase activity
    		•  1.15255422926249 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.691073358419788 bayes_pls_golite062009
  • binding
    		•  0.661198018681765 bayes_pls_golite062009
  • DNA binding
    		•  0.579562080072574 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.547593348248892 bayes_pls_golite062009
  • C-acyltransferase activity
    		•  0.46392133442786 bayes_pls_golite062009
  • transcription factor activity
    		•  0.352624414131738 bayes_pls_golite062009
  • 4-aminobutyrate transaminase activity
    		•  0.122706514261728 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.53

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle