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Protein Overview: Ark-PB

General Information:
Name(s) found: Ark-PB / FBpp0086122 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Apaf-1-related-killer is referred to in FlyBase by the symbol Dmel\Ark (CG6829, FBgn0024252). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12907549..12914208. It has the cytological map location 53E4. Based on sequence similarity, it is predicted to have molecular function</span>: caspase activator activity. There is experimental evidence that it is involved in the biological process</span>: histolysis; activation of caspase activity; activation of caspase activity by cytochrome c; sensory organ development; programmed cell death; response to gamma radiation; sperm individualization; salivary gland cell autophagic cell death; central nervous system formation. 42 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: organ system; nervous system; peripheral nervous system; embryonic nervous system; external compound sense organ; adult segment; adult mesothoracic segment; imaginal precursor; embryonic head; nucleus; dorsal thoracic disc; commissure. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1440 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: sperm individualization [IMP]
    central nervous system formation [IMP]
    salivary gland cell autophagic cell death [IMP]
    response to DNA damage stimulus [TAS]
    activation of caspase activity by cytochrome c [IMP][IPI][TAS]
    regulation of retinal cell programmed cell death [NAS]
    sensory organ development [IMP]
    histolysis [IMP]
    induction of apoptosis [TAS]
    apoptosis [NAS][TAS]
    activation of caspase activity [IPI][ISS][TAS]
    response to gamma radiation [IDA]
    programmed cell death [IDA][NAS]
    Molecular Function: ATP binding [IEA]
    protein binding [TAS]
    caspase activator activity [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFETGEHQY QYKDILSVFE DAFVDNFDCK DVQDMPKSIL SKEEIDHIIM SKDAVSGTLR  60
   61 LFWTLLSKQE EMVQKFVEEV LRINYKFLMS PIKTEQRQPS MMTRMYIEQR DRLYNDNQVF 120
  121 AKYNVSRLQP YLKLRQALLE LRPAKNVLID GVLGSGKTWV ALDVCLSYKV QCKMDFKIFW 180
  181 LNLKNCNSPE TVLEMLQKLL YQIDPNWTSR SDHSSNIKLR IHSIQAELRR LLKSKPYENC 240
  241 LLVLLNVQNA KAWNAFNLSC KILLTTRFKQ VTDFLSAATT THISLDHHSM TLTPDEVKSL 300
  301 LLKYLDCRPQ DLPREVLTTN PRRLSIIAES IRDGLATWDN WKHVNCDKLT TIIESSLNVL 360
  361 EPAEYRKMFD RLSVFPPSAH IPTILLSLIW FDVIKSDVMV VVNKLHKYSL VEKQPKESTI 420
  421 SIPSIYLELK VKLENEYALH RSIVDHYNIP KTFDSDDLIP PYLDQYFYSH IGHHLKNIEH 480
  481 PERMTLFRMV FLDFRFLEQK IRHDSTAWNA SGSILNTLQQ LKFYKPYICD NDPKYERLVN 540
  541 AILDFLPKIE ENLICSKYTD LLRIALMAED EAIFEEAHKQ VQRFDDRVWF TNHGRFHQHR 600
  601 QIINLGDNEG RHAVYLHNDF CLIALASGQI LLTDVSLEGE DTYLLRDESD SSDILRMAVF 660
  661 NQQKHLITLH CNGSVKLWSL WPDCPGRRHS GGSKQQLVNS VVKRFIGSYA NLKIVAFYLN 720
  721 EDAGLPEANI QLHVAFINGD VSILNWDEQD QEFKLSHVPV LKTMQSGIRC FVQVLKRYYV 780
  781 VCTSNCTLTV WDLTNGSSNT LELHVFNVEN DTPLALDVFD ERSKTATVLL IFKYSVWRLN 840
  841 FLPGLSVSLQ SEAVQLPEGS FITCGKRSTD GRYLLLGTSE GLIVYDLKIS DPVLRSNVSE 900
  901 HIECVDIYEL FDPVYKYIVL CGAKGKQVVH VHTLRSVSGS NSHQNREIAW VHSADEISVM 960
  961 TKACLEPNVY LRSLMDMTRE RTQLLAVDSK ERIHLIKPAI SRISEWSTIT PTHAASNCKI1020
 1021 NAISAFNDEQ IFVGYVDGVI IDVIHDTALP QQFIEEPIDY LKQVSPNILV ASAHSAQKTV1080
 1081 IFQLEKIDPL QPNDQWPLMM DVSTKYASLQ EGQYIILFSD HGVCHLDIAN PSAFVKPKDS1140
 1141 EEYIVGFDLK NSLLFLAYEN NIIDVFRLIF SCNQLRYEQI CEEEIAQKAK ISYLVATDDG1200
 1201 TMLAMGFENG TLELFAVENR KVQLIYSIEE VHEHCIRQLL FSPCKLLLIS CAEQLCFWNV1260
 1261 THMRNNQLER EQKRRRSRRH KQHSVTQEDA VDAAPIAADI DVDVTFVADE FHPVNRGTAE1320
 1321 LWRNKRGNAI RPELLACVKF VGNEARQFFT DAHFSHFYAI DDEGVYYHLQ LLELSRLQPP1380
 1381 PDPVTLDIAN QYEDLKNLRI LDSPLMQDSD SEGADVVGNL VLEKNGGVAR ATPILEEASS1440
 1441

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..596] PSI-BLAST 62.0 Structure of the apoptotic protease-activating factor 1 bound to ADP
    2 View Details [597..1169] PSI-BLAST 56.0 Actin interacting protein 1
    3 View Details [1170..1313] PSI-BLAST 26.39794 Crystal Structure Of The C-Terminal WD40 Domain Of Sif2
    4 View Details [1314..1440] PSI-BLAST 63.30103 PAF-AH Holoenzyme: Lis1/Alfa2


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle