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Protein Overview: Sema-2a-PB, Sema...

General Information:
Name(s) found: FBpp0311494 [FlyBase]
Sema-2a-PA / FBpp0086238 [FlyBase]
Sema-2a-PB / FBpp0086237 [FlyBase]
Description(s) found:
Found 43 descriptions.
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  • type=protein; loc=2R:join(12404681..12404846,12412879..12412966,12413218..12413269,12415119..12415187,12416047..12416154,12416404..12416541,12416613..12416745,12416864..12417220,12417755..12417983,12418234..12418570,12418737..12418900,12418964..12419116,12419299..12419407,12419834..12419905); ID=FBpp0311494; name=Sema-2a-PE; parent=FBgn0011260,FBtr0345339; dbxref=FlyBase:FBpp0311494,FlyBase_Annotation_IDs:CG4700-PE; MD5=e87e5b0cd6fd899f5ec7bb88d1ca2f27; length=724; release=r5.56; species=Dmel; [FlyBase]
  • The gene Sema-2a is referred to in FlyBase by the symbol Dmel\Sema-2a (CG4700, FBgn0011260). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12387701..12420934. It has the cytological map location 53C6-53C7. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: adult behavior; axon guidance; visual behavior; flight behavior; synaptic target inhibition; salivary gland development; drinking behavior. 13 alleles are reported. The phenotypes of these alleles are annotated with: abdominal 1 RP3 neuron; abdominal 2 RP1 neuron; RP3 neuron; intersegmental nerve; abdominal 2 RP3 neuron; abdominal segmental nerve; imaginal disc; abdominal 1 RP1 neuron; transverse nerve. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Sema-2a is referred to in FlyBase by the symbol Dmel\Sema-2a (CG4700, FBgn0011260). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12387701..12420934. It has the cytological map location 53C6-53C7. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: adult behavior; axon guidance; visual behavior; flight behavior; synaptic target inhibition; salivary gland development; drinking behavior. 13 alleles are reported. The phenotypes of these alleles are annotated with: abdominal 1 RP3 neuron; abdominal 2 RP1 neuron; RP3 neuron; intersegmental nerve; abdominal 2 RP3 neuron; abdominal segmental nerve; imaginal disc; abdominal 1 RP1 neuron; transverse nerve. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 724 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    extracellular region [ISS][NAS]
    Biological Process: drinking behavior [IMP]
    flight behavior [IMP]
    axon guidance [IMP][NAS]
    salivary gland development [IMP]
    synaptic target inhibition [IMP][NAS]
    visual behavior [IMP]
    adult behavior [IMP][NAS]
    Molecular Function: protein binding [IPI]
    receptor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLLQLSPLL ALLLLLCSSV SETAADYENT WNFYYERPCC TGNDQGNNNY GKHGADHVRE  60
   61 FNCGKLYYRT FHMNEDRDTL YVGAMDRVFR VNLQNISSSN CNRDVINLEP TRDDVVSCVS 120
  121 KGKSQIFDCK NHVRVIQSMD QGDRLYVCGT NAHNPKDYVI YANLTHLPRS EYVIGVGLGI 180
  181 AKCPYDPLDN STAIYVENGN PGGLPGLYSG TNAEFTKADT VIFRTDLYNT SAKRLEYKFK 240
  241 RTLKYDSKWL DKPNFVGSFD IGEYVYFFFR ETAVEYINCG KAVYSRIARV CKKDVGGKNL 300
  301 LAHNWATYLK ARLNCSISGE FPFYFNEIQS VYQLPSDKSR FFATFTTSTN GLIGSAVCSF 360
  361 HINEIQAAFN GKFKEQSSSN SAWLPVLNSR VPEPRPGTCV NDTSNLPDTV LNFIRSHPLM 420
  421 DKAVNHEHNN PVYYKRDLVF TKLVVDKIRI DILNQEYIVY YVGTNLGRIY KIVQYYRNGE 480
  481 SLSKLLDIFE VAPNEAIQVM EISQTRKSLY IGTDHRIKQI DLAMCNRRYD NCFRCVRDPY 540
  541 CGWDKEANTC RPYELDLLQD VANETSDICD SSVLKKKIVV TYGQSVHLGC FVKIPEVLKN 600
  601 EQVTWYHHSK DKGRYEIRYS PTKYIETTER GLVVVSVNEA DGGRYDCHLG GSLLCSYNIT 660
  661 VDAHRCTPPN KSNDYQKIYS DWCHEFEKYK TAMKSWEKKQ AQCSTRQNFS SNQHPNEIFR 720
  721 KPNV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..724] PSI-BLAST 101.0 The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antigen binding
    		•  4.06466268219034 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.9185026130375 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.8360014271135 bayes_pls_golite062009
  • chemorepellent activity
    		•  1.79885899802089 bayes_pls_golite062009
  • receptor activity
    		•  1.73411211759611 bayes_pls_golite062009
  • receptor binding
    		•  1.69538764684177 bayes_pls_golite062009
  • binding
    		•  1.56912444046433 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.48908901984354 bayes_pls_golite062009
  • signal transducer activity
    		•  1.48908901984354 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.25652075776666 bayes_pls_golite062009
  • protein complex binding
    		•  1.19581190330569 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.17930092269192 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.16887356905525 bayes_pls_golite062009
  • protein binding
    		•  1.12981051950964 bayes_pls_golite062009
  • peptide antigen binding
    		•  1.03871842737922 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  0.68620352874827 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.63737386998612 bayes_pls_golite062009
  • integrin binding
    		•  0.32413307774101 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.31988469097193 bayes_pls_golite062009
  • viral receptor activity
    		•  0.171304187186109 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.106172197004716 bayes_pls_golite062009
  • growth factor binding
    		•  0.0783438827475496 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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