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View Structure Prediction Details

Protein: Sema-2a-PB, Sema...
Organism: Drosophila melanogaster
Length: 724 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sema-2a-PB, Sema....

Description E-value Query
Range
Subject
Range
Sema-2a-PC - The gene Sema-2a is referred to in FlyBase by the symbol Dmel\Sema-2a (CG4700, FBgn0011260). It is a...
530.0 [0..38] [724..11]

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Predicted Domain #1
Region A:
Residues: [1-724]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLLQLSPLL ALLLLLCSSV SETAADYENT WNFYYERPCC TGNDQGNNNY GKHGADHVRE  60
   61 FNCGKLYYRT FHMNEDRDTL YVGAMDRVFR VNLQNISSSN CNRDVINLEP TRDDVVSCVS 120
  121 KGKSQIFDCK NHVRVIQSMD QGDRLYVCGT NAHNPKDYVI YANLTHLPRS EYVIGVGLGI 180
  181 AKCPYDPLDN STAIYVENGN PGGLPGLYSG TNAEFTKADT VIFRTDLYNT SAKRLEYKFK 240
  241 RTLKYDSKWL DKPNFVGSFD IGEYVYFFFR ETAVEYINCG KAVYSRIARV CKKDVGGKNL 300
  301 LAHNWATYLK ARLNCSISGE FPFYFNEIQS VYQLPSDKSR FFATFTTSTN GLIGSAVCSF 360
  361 HINEIQAAFN GKFKEQSSSN SAWLPVLNSR VPEPRPGTCV NDTSNLPDTV LNFIRSHPLM 420
  421 DKAVNHEHNN PVYYKRDLVF TKLVVDKIRI DILNQEYIVY YVGTNLGRIY KIVQYYRNGE 480
  481 SLSKLLDIFE VAPNEAIQVM EISQTRKSLY IGTDHRIKQI DLAMCNRRYD NCFRCVRDPY 540
  541 CGWDKEANTC RPYELDLLQD VANETSDICD SSVLKKKIVV TYGQSVHLGC FVKIPEVLKN 600
  601 EQVTWYHHSK DKGRYEIRYS PTKYIETTER GLVVVSVNEA DGGRYDCHLG GSLLCSYNIT 660
  661 VDAHRCTPPN KSNDYQKIYS DWCHEFEKYK TAMKSWEKKQ AQCSTRQNFS SNQHPNEIFR 720
  721 KPNV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 101.0
Match: 1olzA
Description: The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antigen binding 4.06466268219034 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.9185026130375 bayes_pls_golite062009
fibroblast growth factor receptor activity 1.8360014271135 bayes_pls_golite062009
chemorepellent activity 1.79885899802089 bayes_pls_golite062009
receptor activity 1.73411211759611 bayes_pls_golite062009
receptor binding 1.69538764684177 bayes_pls_golite062009
binding 1.56912444046433 bayes_pls_golite062009
molecular transducer activity 1.48908901984354 bayes_pls_golite062009
signal transducer activity 1.48908901984354 bayes_pls_golite062009
axon guidance receptor activity 1.25652075776666 bayes_pls_golite062009
protein complex binding 1.19581190330569 bayes_pls_golite062009
transmembrane receptor activity 1.17930092269192 bayes_pls_golite062009
fibroblast growth factor binding 1.16887356905525 bayes_pls_golite062009
protein binding 1.12981051950964 bayes_pls_golite062009
peptide antigen binding 1.03871842737922 bayes_pls_golite062009
platelet-derived growth factor receptor binding 0.68620352874827 bayes_pls_golite062009
cell adhesion molecule binding 0.63737386998612 bayes_pls_golite062009
integrin binding 0.32413307774101 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.31988469097193 bayes_pls_golite062009
viral receptor activity 0.171304187186109 bayes_pls_golite062009
cytoskeletal protein binding 0.106172197004716 bayes_pls_golite062009
growth factor binding 0.0783438827475496 bayes_pls_golite062009

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