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Protein Overview: Sema-2a-PC

General Information:
Name(s) found: Sema-2a-PC / FBpp0086236 [FlyBase]
Description(s) found:
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  • gi|24654174|ref|NP_725586.1| Sema-2a, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|21627096|gb|AAM68500.1| Sema-2a, isoform C [Drosophila melanogaster] [NCBI NR]
  • The gene Sema-2a is referred to in FlyBase by the symbol Dmel\Sema-2a (CG4700, FBgn0011260). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12387701..12420934. It has the cytological map location 53C6-53C7. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: adult behavior; axon guidance; visual behavior; flight behavior; synaptic target inhibition; salivary gland development; drinking behavior. 13 alleles are reported. The phenotypes of these alleles are annotated with: abdominal 1 RP3 neuron; abdominal 2 RP1 neuron; RP3 neuron; intersegmental nerve; abdominal 2 RP3 neuron; abdominal segmental nerve; imaginal disc; abdominal 1 RP1 neuron; transverse nerve. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG4700-PC translation from_gene[CG4700 Sema-2a FBgn0011260] seq_release:3 mol_weight=80030 cds_boundaries:(2R:11,567,273..11,596,122[+]) aa_length:697 transcript_info:[CG4700-RC seq_release:3] gene_info:[gene symbol:Sema-2a FBgn0011260 gene_boundaries [hmr_yeast5_DM3-1_pombe.fasta]
  • CG4700-PC, isoform C [Drosophila melanogaster]gi|24654174|ref|NP_725586.1| CG4700-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(12391053..12391137,12412879..12412966,12413218..12413269,12415119..12415187,12416047..12416154,12416404..12416541,12416613..12416745,12416864..12417220,12417755..12417983,12418234..12418570,12418737..12418900,12418964..12419116,1 [fly-100309-contam.fasta]
  • Sema-2a CG4700-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG4700-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(12391053..12391137,12412879..12412966,12413218..12413269,12415119..12415187,12416047..12416154,12416404..12416541,12416613..12416745,12416864..12417220,12417755..12417983,12418234..12418570,12418737..12418900,12418964..12419116,12419299..12419407,12419834..12419905); ID=FBpp0086236; name=Sema-2a-PC; parent=FBgn0011260,FBtr0087088; dbxref=FlyBase:FBpp0086236,FlyBase_Annotation_IDs:CG4700-PC,GB_protein:AAM68500.1,REFSEQ:NP_725586,GB_protein:AAM68500; MD5=c183341c609773d030107d34e67d1ba9; length=697; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(12391053..12391137,12412879..12412966,12413218..12413269,12415119..12415187,12416047..12416154,12416404..12416541,12416613..12416745,12416864..12417220,12417755..12417983,12418234..12418570,12418737..12418900,12418964..12419116,12419299..12419407,12419834..12419905); ID=FBpp0086236; name=Sema-2a-PC; parent=FBgn0011260,FBtr0087088; dbxref=FlyBase:FBpp0086236,FlyBase_Annotation_IDs:CG4700-PC,GB_protein:AAM68500.1,REFSEQ:NP_725586,GB_protein:AAM68500; MD5=c183341c609773d030107d34e67d1ba9; length=697; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform C of Semaphorin-2A OS=Drosophila melanogaster GN=Sema-2a [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(12391053..12391137,12412879..12412966,12413218..12413269,12415119..12415187,12416047..12416154,12416404..12416541,12416613..12416745,12416864..12417220,12417755..12417983,12418234..12418570,12418737..12418900,12418964..12419116,12419299..12419407,12419834..12419905); ID=FBpp0086236; name=Sema-2a-PC; parent=FBgn0011260,FBtr0087088; dbxref=FlyBase:FBpp0086236,FlyBase_Annotation_IDs:CG4700-PC,GB_protein:AAM68500.1,REFSEQ:NP_725586,GB_protein:AAM68500,FlyMine:FBpp0086236,modMine:FBpp0086236; MD5=c183341c609773d030107d34e67d1ba9; length=697; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(16503548..16503632,16525374..16525461,16525713..16525764,16527614..16527682,16528542..16528649,16528899..16529036,16529108..16529240,16529359..16529715,16530250..16530478,16530729..16531065,16531232..16531395,16531459..16531611,16531794..16531902,16532329..16532400); ID=FBpp0086236; name=Sema-2a-PC; parent=FBgn0011260,FBtr0087088; dbxref=FlyBase:FBpp0086236,FlyBase_Annotation_IDs:CG4700-PC,GB_protein:AAM68500.1,REFSEQ:NP_725586,GB_protein:AAM68500,FlyMine:FBpp0086236,modMine:FBpp0086236; MD5=c183341c609773d030107d34e67d1ba9; length=697; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(16503548..16503632,16525374..16525461,16525713..16525764,16527614..16527682,16528542..16528649,16528899..16529036,16529108..16529240,16529359..16529715,16530250..16530478,16530729..16531065,16531232..16531395,16531459..16531611,16531794..16531902,16532329..16532400); ID=FBpp0086236; name=Sema-2a-PC; parent=FBgn0011260,FBtr0087088; dbxref=FlyBase:FBpp0086236,FlyBase_Annotation_IDs:CG4700-PC,GB_protein:AAM68500.1,REFSEQ:NP_725586,GB_protein:AAM68500,FlyMine:FBpp0086236,modMine:FBpp0086236; MD5=c183341c609773d030107d34e67d1ba9; length=697; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q24323, Isoform C of Semaphorin-2A OS=Drosophila melanogaster GN=Sema-2a [DROME.fasta.20160308]
  • FBpp0086236 type=protein; loc=2R:join(16503548..16503632,16525374..16525461,16525713..16525764,16527614..16527682,16528542..16528649,16528899..16529036,16529108..16529240,16529359..16529715,16530250..16530478,16530729..16531065,16531232..16531395,16531459..16531611,16531794..16531902,16532329..16532400); ID=FBpp0086236; name=Sema-2a-PC; parent=FBgn0011260,FBtr0087088; dbxref=FlyBase:FBpp0086236,FlyBase_Annotation_IDs:CG4700-PC,GB_protein:AAM68500.1,REFSEQ:NP_725586,GB_protein:AAM68500,FlyMine:FBpp0086236,modMine:FBpp0086236; MD5=c183341c609773d030107d34e67d1ba9; length=697; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(16503548..16503632,16525374..16525461,16525713..16525764,16527614..16527682,16528542..16528649,16528899..16529036,16529108..16529240,16529359..16529715,16530250..16530478,16530729..16531065,16531232..16531395,16531459..16531611,16531794..16531902,16532329..16532400); ID=FBpp0086236; name=Sema2a-PC; parent=FBgn0011260,FBtr0087088; dbxref=FlyBase:FBpp0086236,FlyBase_Annotation_IDs:CG4700-PC,GB_protein:AAM68500.1,REFSEQ:NP_725586,GB_protein:AAM68500,FlyMine:FBpp0086236,modMine:FBpp0086236; MD5=c183341c609773d030107d34e67d1ba9; length=697; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 697 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGIHWLLFG SCLMLISQIE AVTEELSPDH VREFNCGKLY YRTFHMNEDR DTLYVGAMDR  60
   61 VFRVNLQNIS SSNCNRDVIN LEPTRDDVVS CVSKGKSQIF DCKNHVRVIQ SMDQGDRLYV 120
  121 CGTNAHNPKD YVIYANLTHL PRSEYVIGVG LGIAKCPYDP LDNSTAIYVE NGNPGGLPGL 180
  181 YSGTNAEFTK ADTVIFRTDL YNTSAKRLEY KFKRTLKYDS KWLDKPNFVG SFDIGEYVYF 240
  241 FFRETAVEYI NCGKAVYSRI ARVCKKDVGG KNLLAHNWAT YLKARLNCSI SGEFPFYFNE 300
  301 IQSVYQLPSD KSRFFATFTT STNGLIGSAV CSFHINEIQA AFNGKFKEQS SSNSAWLPVL 360
  361 NSRVPEPRPG TCVNDTSNLP DTVLNFIRSH PLMDKAVNHE HNNPVYYKRD LVFTKLVVDK 420
  421 IRIDILNQEY IVYYVGTNLG RIYKIVQYYR NGESLSKLLD IFEVAPNEAI QVMEISQTRK 480
  481 SLYIGTDHRI KQIDLAMCNR RYDNCFRCVR DPYCGWDKEA NTCRPYELDL LQDVANETSD 540
  541 ICDSSVLKKK IVVTYGQSVH LGCFVKIPEV LKNEQVTWYH HSKDKGRYEI RYSPTKYIET 600
  601 TERGLVVVSV NEADGGRYDC HLGGSLLCSY NITVDAHRCT PPNKSNDYQK IYSDWCHEFE 660
  661 KYKTAMKSWE KKQAQCSTRQ NFSSNQHPNE IFRKPNV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..636] PSI-BLAST 96.39794 The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D
    2 View Details [637..697] PSI-BLAST 12.69897 No description for 2illA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antigen binding
    		•  4.06466268219034 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  3.22003832960927 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  2.46885430509177 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.8360014271135 bayes_pls_golite062009
  • chemorepellent activity
    		•  1.79885899802089 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.77462533261228 bayes_pls_golite062009
  • receptor activity
    		•  1.73411211759611 bayes_pls_golite062009
  • receptor binding
    		•  1.69538764684177 bayes_pls_golite062009
  • actin binding
    		•  1.57909436422457 bayes_pls_golite062009
  • binding
    		•  1.56912444046433 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.48908901984354 bayes_pls_golite062009
  • signal transducer activity
    		•  1.48908901984354 bayes_pls_golite062009
  • actin filament binding
    		•  1.47359288623575 bayes_pls_golite062009
  • semaphorin receptor activity
    		•  1.39530633894436 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  1.25652075776666 bayes_pls_golite062009
  • protein complex binding
    		•  1.19581190330569 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.17930092269192 bayes_pls_golite062009
  • protein binding
    		•  1.12981051950964 bayes_pls_golite062009
  • peptide antigen binding
    		•  1.03871842737922 bayes_pls_golite062009
  • hepatocyte growth factor receptor activity
    		•  0.723051846539421 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  0.68620352874827 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.63737386998612 bayes_pls_golite062009
  • integrin binding
    		•  0.32413307774101 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.31988469097193 bayes_pls_golite062009
  • viral receptor activity
    		•  0.171304187186109 bayes_pls_golite062009
  • growth factor binding
    		•  0.0783438827475496 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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