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View Structure Prediction Details

Protein: Sema-2a-PC
Organism: Drosophila melanogaster
Length: 697 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sema-2a-PC.

Description E-value Query
Range
Subject
Range
gi|41058083 - gi|41058083|gb|AAR99105.1| RE45189p [Drosophila melanogaster]
531.0 [0..1] [697..1]

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Predicted Domain #1
Region A:
Residues: [1-636]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGIHWLLFG SCLMLISQIE AVTEELSPDH VREFNCGKLY YRTFHMNEDR DTLYVGAMDR  60
   61 VFRVNLQNIS SSNCNRDVIN LEPTRDDVVS CVSKGKSQIF DCKNHVRVIQ SMDQGDRLYV 120
  121 CGTNAHNPKD YVIYANLTHL PRSEYVIGVG LGIAKCPYDP LDNSTAIYVE NGNPGGLPGL 180
  181 YSGTNAEFTK ADTVIFRTDL YNTSAKRLEY KFKRTLKYDS KWLDKPNFVG SFDIGEYVYF 240
  241 FFRETAVEYI NCGKAVYSRI ARVCKKDVGG KNLLAHNWAT YLKARLNCSI SGEFPFYFNE 300
  301 IQSVYQLPSD KSRFFATFTT STNGLIGSAV CSFHINEIQA AFNGKFKEQS SSNSAWLPVL 360
  361 NSRVPEPRPG TCVNDTSNLP DTVLNFIRSH PLMDKAVNHE HNNPVYYKRD LVFTKLVVDK 420
  421 IRIDILNQEY IVYYVGTNLG RIYKIVQYYR NGESLSKLLD IFEVAPNEAI QVMEISQTRK 480
  481 SLYIGTDHRI KQIDLAMCNR RYDNCFRCVR DPYCGWDKEA NTCRPYELDL LQDVANETSD 540
  541 ICDSSVLKKK IVVTYGQSVH LGCFVKIPEV LKNEQVTWYH HSKDKGRYEI RYSPTKYIET 600
  601 TERGLVVVSV NEADGGRYDC HLGGSLLCSY NITVDA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 96.39794
Match: 1olzA
Description: The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antigen binding 4.06466268219034 bayes_pls_golite062009
fibroblast growth factor 1 binding 3.22003832960927 bayes_pls_golite062009
fibroblast growth factor binding 2.46885430509177 bayes_pls_golite062009
fibroblast growth factor receptor activity 1.8360014271135 bayes_pls_golite062009
chemorepellent activity 1.79885899802089 bayes_pls_golite062009
cytoskeletal protein binding 1.77462533261228 bayes_pls_golite062009
receptor activity 1.73411211759611 bayes_pls_golite062009
receptor binding 1.69538764684177 bayes_pls_golite062009
actin binding 1.57909436422457 bayes_pls_golite062009
binding 1.56912444046433 bayes_pls_golite062009
molecular transducer activity 1.48908901984354 bayes_pls_golite062009
signal transducer activity 1.48908901984354 bayes_pls_golite062009
actin filament binding 1.47359288623575 bayes_pls_golite062009
semaphorin receptor activity 1.39530633894436 bayes_pls_golite062009
axon guidance receptor activity 1.25652075776666 bayes_pls_golite062009
protein complex binding 1.19581190330569 bayes_pls_golite062009
transmembrane receptor activity 1.17930092269192 bayes_pls_golite062009
protein binding 1.12981051950964 bayes_pls_golite062009
peptide antigen binding 1.03871842737922 bayes_pls_golite062009
hepatocyte growth factor receptor activity 0.723051846539421 bayes_pls_golite062009
platelet-derived growth factor receptor binding 0.68620352874827 bayes_pls_golite062009
cell adhesion molecule binding 0.63737386998612 bayes_pls_golite062009
integrin binding 0.32413307774101 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.31988469097193 bayes_pls_golite062009
viral receptor activity 0.171304187186109 bayes_pls_golite062009
growth factor binding 0.0783438827475496 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [637-697]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRCTPPNKSN DYQKIYSDWC HEFEKYKTAM KSWEKKQAQC STRQNFSSNQ HPNEIFRKPN  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 2illA
Description: No description for 2illA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle