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Protein Overview: Menl-2-PC

General Information:
Name(s) found: Menl-2-PC / FBpp0100061 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Menl-2 is referred to in FlyBase by the symbol Dmel\Menl-2 (CG7969, FBgn0029153). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12302320..12306903. It has the cytological map location 53C4. Based on sequence similarity, it is predicted to have molecular function</span>: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: malate metabolic process. No alleles are reported. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 558 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: malate metabolic process [IEA]
    Molecular Function: NAD or NADH binding [IEA]
    malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEFRRLHPLL RLASRPLLSS SRRFSVYDDE MEQITRPDWH VVMNGKYNKG LAFTIKERQR  60
   61 LGIMGLMPCS VRSMDDQMNA ALANFEARPT DIARFTYLSA VHHRHRRLYY RFIKENIEKS 120
  121 LPIVYTPTVG DVVATYGLNF QQAISLFISI HDKGHIRDLM HNWVDEGVKA ICVTDGGRVL 180
  181 GLGDMGANAM GISLGKMILY TALGSIPPST LMPVCLDVGT DNQALLQDPL YVGARIPRVK 240
  241 GPEYDELVDE FMESAVKCFG NNTFIHFEDF ATPNALKFLE KYQYKYCCFN DDIQGTGATG 300
  301 LAAFINVERI TGRKLEDTVF LFVGAGSAAL GIANMLAMEL EVRGIPAEEA TKNIYLMDVN 360
  361 GILTPESPNP PEMGKIFIKS MEPMKDMMAV LKKLKPSVLV GATGVGGIFN EEVLKTMAKN 420
  421 HERPAVFPLS NPTANSECTA EQAFTHTEGR VLFGSGSPFP PVVINGKRYR PAQANNCLTF 480
  481 PGIALAAITA KARYLPNEVF SVVSHELARN TPQELLDEGT LFPPIKDAHN VAFNVGVAMT 540
  541 QYLIDNGKIS LVIQTASK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..558] PSI-BLAST 1000.0 Mitochondrial NAD(P)-dependenent malic enzyme

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • malate dehydrogenase activity
    		•  8.2923573833126 bayes_pls_golite062009
  • malic enzyme activity
    		•  6.14953296739671 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  3.85693345778103 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.54983447672782 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.66605122152932 bayes_pls_golite062009
  • catalytic activity
    		•  2.0643953589843 bayes_pls_golite062009
  • shikimate 5-dehydrogenase activity
    		•  1.82286236344978 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.54527841865655 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  1.27032644348698 bayes_pls_golite062009
  • binding
    		•  1.21980641378611 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.74536049628503 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.729242797855749 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.527946013169731 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.33551402794014 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.19685680097448 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.152651308844322 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
    		•  0.13669372647381 bayes_pls_golite062009
  • glutamate dehydrogenase (NADP+) activity
    		•  0.00742771196951075 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.52

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle