Protein Overview: krimp-PA

General Information:
Name(s) found:	krimp-PA / FBpp0086333 [FlyBase]
Description(s) found: Found 19 descriptions. SHOW ALL	The gene krimper is referred to in FlyBase by the symbol Dmel\krimp (CG15707, FBgn0034098). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12125606..12128222. It has the cytological map location 53A1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of oskar mRNA translation; oocyte dorsal/ventral axis specification; karyosome formation. 7 alleles are reported. The phenotypes of these alleles are annotated with: chorion; karyosome. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	746 amino acids
Gene Ontology:
Cellular Component:	perinuclear region of cytoplasm [IDA] P granule [IDA]
Biological Process:	negative regulation of oskar mRNA translation [IMP] karyosome formation [IMP] oocyte dorsal/ventral axis specification [IMP]
Molecular Function:	nucleic acid binding [IEA] zinc ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLEDISMIM KLFDSNMHKL QGNLRSYQTE MHQIHKELTE KLSHADLLYR SLIPLHDHLV  60
   61 ASLSEVNAHV MKLNVQLHIN RQSVRLGDYE YYEKSIDNPY SSIRSGLQAI EKPGCAEAIC 120
  121 QSSKPAFVEC LPSSTSEEVP VVAVQEASST NQLDAISVVN ENLSEERDAT PQPLAVSKNM 180
  181 EETMPSNPFH EQLEGSLEEI PVGSKIVVET EKANNPVRSE ASAPATSDNQ SLLAAKQGTQ 240
  241 TIGTGICNKI SKSTINMPNN WQLENPTEVT AASIEKVNKL PKSPRNRFLL PPKGGTETTR 300
  301 RDIYNQILKD MAAFPENTIV TAVLASVDVT DNCAYVAKWD ESSDRIKKVL QRQLPLQELD 360
  361 QLPDYGDIFA VLDSINNIIT RITINSSSAG GGYDAYLIDF GEHIHFDGNE TIFKLPDDIK 420
  421 RLPAQAIRCD LINCDIANMH CFVNTYIKIR VHENNNSTLV AEPVIDRLSR PTKTNTTKYP 480
  481 AGITEDDMAM LNEIDESTSD PLKAVLGFRP KDEQRICRHY DPKLNGCFKG NNCRFAHEPF 540
  541 APNGATKDVE LARALPETIF DTTVHFEIGS IVGILITFIN GPTEVYGQFL DGSPPLVWDK 600
  601 KDVPENKRTF KSKPRLLDIV LALYSDGCFY RAQIIDEFPS EYMIFYVDYG NTEFVPLSCL 660
  661 APCENVDSFK PHRVFSFHIE GIVRSKNLTH QKTIECIEYL KSKLLNTEMN VHLVQRLPDG 720
  721 FLIRFLDDWK YIPEQLLQRN YAQVSQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..81]	deduced	N/A	No confident structure predictions are available.
2	View Details	[82..217]	MSA	1.041995	View MSA. No confident structure predictions are available.
3	View Details	[218..297]	deduced	N/A	No confident structure predictions are available.
4	View Details	[298..436]	PSI-BLAST	10.39794	No description for 2d9tA was found.
5	View Details	[437..553]	FFAS03	1.18	No description for 2d9mA was found.
6	View Details	[554..746]	PSI-BLAST	37.30103	No description for 2hqeA was found.

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

No functions predicted.

4

Term	Confidence	Notes
binding	2.60998973020963	bayes_pls_golite062009
transcription repressor activity	2.33861387740649	bayes_pls_golite062009
transcription regulator activity	2.19872709046627	bayes_pls_golite062009
protein binding	1.76914488602752	bayes_pls_golite062009
histone methyltransferase activity	1.68557512550835	bayes_pls_golite062009
histone binding	1.42699325473147	bayes_pls_golite062009
DNA binding	1.36613258095775	bayes_pls_golite062009
nucleic acid binding	1.33146849973268	bayes_pls_golite062009
lysine N-methyltransferase activity	1.20933027041944	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	1.20933027041944	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	1.20933027041944	bayes_pls_golite062009
chromatin binding	0.98282919061767	bayes_pls_golite062009
protein methyltransferase activity	0.937656130642761	bayes_pls_golite062009
transcription corepressor activity	0.858902267969751	bayes_pls_golite062009
transcription factor binding	0.80529345551372	bayes_pls_golite062009
transcription cofactor activity	0.65687417812623	bayes_pls_golite062009
transcription factor activity	0.453415046852858	bayes_pls_golite062009
methylated histone residue binding	0.35315659904958	bayes_pls_golite062009

5

No functions predicted.

6

Term	Confidence	Notes
binding	2.60998973020963	bayes_pls_golite062009
transcription repressor activity	2.33861387740649	bayes_pls_golite062009
transcription regulator activity	2.19872709046627	bayes_pls_golite062009
protein binding	1.76914488602752	bayes_pls_golite062009
histone methyltransferase activity	1.68557512550835	bayes_pls_golite062009
histone binding	1.42699325473147	bayes_pls_golite062009
DNA binding	1.36613258095775	bayes_pls_golite062009
nucleic acid binding	1.33146849973268	bayes_pls_golite062009
lysine N-methyltransferase activity	1.20933027041944	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	1.20933027041944	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	1.20933027041944	bayes_pls_golite062009
chromatin binding	0.98282919061767	bayes_pls_golite062009
protein methyltransferase activity	0.937656130642761	bayes_pls_golite062009
transcription corepressor activity	0.858902267969751	bayes_pls_golite062009
transcription factor binding	0.80529345551372	bayes_pls_golite062009
transcription cofactor activity	0.65687417812623	bayes_pls_golite062009
transcription factor activity	0.453415046852858	bayes_pls_golite062009
methylated histone residue binding	0.35315659904958	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

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