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View Structure Prediction Details

Protein: krimp-PA
Organism: Drosophila melanogaster
Length: 746 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for krimp-PA.

Description E-value Query
Range
Subject
Range
gi|25012741 - gi|25012741|gb|AAN71463.1| RE66405p [Drosophila melanogaster]
559.0 [0..1] [656..1]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLEDISMIM KLFDSNMHKL QGNLRSYQTE MHQIHKELTE KLSHADLLYR SLIPLHDHLV  60
   61 ASLSEVNAHV MKLNVQLHIN R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [82-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSVRLGDYEY YEKSIDNPYS SIRSGLQAIE KPGCAEAICQ SSKPAFVECL PSSTSEEVPV  60
   61 VAVQEASSTN QLDAISVVNE NLSEERDATP QPLAVSKNME ETMPSNPFHE QLEGSLEEIP 120
  121 VGSKIVVETE KANNPV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [218-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSEASAPATS DNQSLLAAKQ GTQTIGTGIC NKISKSTINM PNNWQLENPT EVTAASIEKV  60
   61 NKLPKSPRNR FLLPPKGGTE 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [298-436]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTRRDIYNQI LKDMAAFPEN TIVTAVLASV DVTDNCAYVA KWDESSDRIK KVLQRQLPLQ  60
   61 ELDQLPDYGD IFAVLDSINN IITRITINSS SAGGGYDAYL IDFGEHIHFD GNETIFKLPD 120
  121 DIKRLPAQAI RCDLINCDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 2d9tA
Description: No description for 2d9tA was found.

Predicted functions:

Term Confidence Notes
binding 2.60998973020963 bayes_pls_golite062009
transcription repressor activity 2.33861387740649 bayes_pls_golite062009
transcription regulator activity 2.19872709046627 bayes_pls_golite062009
protein binding 1.76914488602752 bayes_pls_golite062009
histone methyltransferase activity 1.68557512550835 bayes_pls_golite062009
histone binding 1.42699325473147 bayes_pls_golite062009
DNA binding 1.36613258095775 bayes_pls_golite062009
nucleic acid binding 1.33146849973268 bayes_pls_golite062009
lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
chromatin binding 0.98282919061767 bayes_pls_golite062009
protein methyltransferase activity 0.937656130642761 bayes_pls_golite062009
transcription corepressor activity 0.858902267969751 bayes_pls_golite062009
transcription factor binding 0.80529345551372 bayes_pls_golite062009
transcription cofactor activity 0.65687417812623 bayes_pls_golite062009
transcription factor activity 0.453415046852858 bayes_pls_golite062009
methylated histone residue binding 0.35315659904958 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [437-553]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANMHCFVNTY IKIRVHENNN STLVAEPVID RLSRPTKTNT TKYPAGITED DMAMLNEIDE  60
   61 STSDPLKAVL GFRPKDEQRI CRHYDPKLNG CFKGNNCRFA HEPFAPNGAT KDVELAR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.18
Match: 2d9mA
Description: No description for 2d9mA was found.

Predicted Domain #6
Region A:
Residues: [554-746]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALPETIFDTT VHFEIGSIVG ILITFINGPT EVYGQFLDGS PPLVWDKKDV PENKRTFKSK  60
   61 PRLLDIVLAL YSDGCFYRAQ IIDEFPSEYM IFYVDYGNTE FVPLSCLAPC ENVDSFKPHR 120
  121 VFSFHIEGIV RSKNLTHQKT IECIEYLKSK LLNTEMNVHL VQRLPDGFLI RFLDDWKYIP 180
  181 EQLLQRNYAQ VSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.30103
Match: 2hqeA
Description: No description for 2hqeA was found.

Predicted functions:

Term Confidence Notes
binding 2.60998973020963 bayes_pls_golite062009
transcription repressor activity 2.33861387740649 bayes_pls_golite062009
transcription regulator activity 2.19872709046627 bayes_pls_golite062009
protein binding 1.76914488602752 bayes_pls_golite062009
histone methyltransferase activity 1.68557512550835 bayes_pls_golite062009
histone binding 1.42699325473147 bayes_pls_golite062009
DNA binding 1.36613258095775 bayes_pls_golite062009
nucleic acid binding 1.33146849973268 bayes_pls_golite062009
lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.20933027041944 bayes_pls_golite062009
chromatin binding 0.98282919061767 bayes_pls_golite062009
protein methyltransferase activity 0.937656130642761 bayes_pls_golite062009
transcription corepressor activity 0.858902267969751 bayes_pls_golite062009
transcription factor binding 0.80529345551372 bayes_pls_golite062009
transcription cofactor activity 0.65687417812623 bayes_pls_golite062009
transcription factor activity 0.453415046852858 bayes_pls_golite062009
methylated histone residue binding 0.35315659904958 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle